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| Product | Description | |
|---|---|---|
| Batefenterol | Batefenterol is a Beta 2 adrenergic receptor agonist and also a Muscarinic receptor antagonist. It shows high affinity for hM2 (Ki = 1.4 nM), hM3 muscarinic receptors (Ki = 1.3 nM) and hβ2-adrenoceptors (Ki = 3.7 nM). Batefenterol is a hβ2-adrenoceptor agonist with EC50 value of 0.29 nM for stimulation of cAMP levels. This is 440- and 320-fold functional selectivity over hβ1- and hβ3-adrenoceptors. In Jul 2016, GlaxoSmithKline completed a phase II trial for Chronic obstructive pulmonary disease in USA, Germany and South Africa. Uses: Chronic obstructive pulmonary disease. Synonyms: GSK-961081; TD-5959; GSK 961081; TD 5959; GSK961081; TD5959; (R)-1-(3-((2-chloro-4-(((2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)-5-methoxyphenyl)amino)-3-oxopropyl)piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate. Grades: 98%. CAS No. 743461-65-6. Molecular formula: C40H42ClN5O7. Mole weight: 740.25. |  |
| Batefenterol Succinate | Batefenterol is a beta 2 adrenergic receptor agonist and also a muscarinic receptor antagonist. It shows high affinity for hM2 (Ki = 1.4 nM), hM3 muscarinic receptors (Ki = 1.3 nM) and hβ2-adrenoceptors (Ki = 3.7 nM). Batefenterol is a hβ2-adrenoceptor agonist with EC50 value of 0.29 nM for stimulation of cAMP levels. This is 440- and 320-fold functional selectivity over hβ1- and hβ3-adrenoceptors. Synonyms: Batefenterol Succinate; 945905-37-3; UNII-552KVF22JT; Batefenterol succinate [USAN]552KVF22JT. CAS No. 945905-37-3. Molecular formula: C44H48ClN5O11. Mole weight: 858.3. | |
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