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| Product | Description | |
|---|---|---|
| Bay 11-7082 | ?98% (HPLC), powder. Group: Fluorescence/luminescence spectroscopy. |  |
| BAY 11-7082 | BAY 11-7082 completely and specifically abrogates NF-κB DNA binding, downregulating the NF-κB-inducible cytokine IL-6 and inducing apoptosis. Synonyms: BAY 11-7821; BAY 11-7082; BAY11-7082; BAY-11-7082; BAY 117082; BAY117082; BAY-117082. Grades: >98%. CAS No. 19542-67-7. Molecular formula: C10H9NO2S. Mole weight: 207.25. |  |
| BAY 11-7082 | BAY 11-7082 is an IκBα phosphorylation and NF-κB inhibitor. BAY 11-7082 selectively and irreversibly inhibits the TNF-α-induced phosphorylation of IκB-α, and decreases NF-κB and expression of adhesion molecules. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 ( IC 50 =0.19, 0.96 μM, respectively). BAY 11-7082 inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BAY 11-7821. CAS No. 19542-67-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13453. |  |
| BAY 11-7082 | IkappaBalpha kinase inhibitor. NF-kappaB inhibitor. Potential anti-inflammatory agent. Apoptosis inducer. Inhibits the release of proinflammatory cytokines. Inflammasome inhibitor Inhibits platelet aggregation. Group: Biochemicals. Alternative Names: (E)-3-(4-Methylphenylsulfonyl)-2-propenenenitrile. Grades: Highly Purified. CAS No. 19542-67-7. Pack Sizes: 10mg, 50mg. Molecular Formula: C10H9NO2S. US Biological Life Sciences. |  Worldwide |
| BAY 11-7082 ((E)-3-(4-Methylphenylsulfonyl)-2-propenenenitrile) | Potential anti-inflammatory agent. Selectively and irreversibly inhibits NF-kB activation by blocking TNF-a-induced phosphorylation of IkB-a without affecting constitutive IkB-a phosphorylation. Inhibits the TNF-a-induced surface expression of adhesion molecules ICAM-1, VCAM-1, and E-selectin in human endothelial cells with IC50 values of 5-10uM. Group: Biochemicals. Grades: Highly Purified. CAS No. 195462-67-7. Pack Sizes: 10mg, 50ug. US Biological Life Sciences. | Worldwide |
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