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BAY 56-3722 BAY 56-3722 is a water-soluble camptothecin derivative conjugated to a carbohydrate moiety exhibiting antineoplastic activity. BAY 56-3722 stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-drug-DNA ternary complex. The peptide carbohydrate moiety of this agent stabilizes the lactone form of camptothecin in blood. Synonyms: BAY-563722; BAY56 3722; BAY 38-3441; BAY 38 344; (S)-4-ethyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl ((4-(((2R,3S,4R,5R,6S)-3,5-dihydroxy-4-methoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)phenyl)carbamothioyl)-L-histidyl-L-valinate. CAS No. 215604-75-4. Molecular formula: C45H50ClN7O11S. Mole weight: 895.98. BOC Sciences 11
BAY 56-3722 hydrochloride BAY 56-3722, a water-soluble camptothecin derivative, is a DNA-Intercalating drug that stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-drug-DNA ternary complex. Synonyms: BAY 56-3722; BAY56-3722; BAY-56-3722; N-[4- (6-Deoxy-3-O-methyl-beta-L-galactopyranosyloxy) phenylaminothiocarbonyl]-L-histidyl-L-valine 4(S)-ethyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl ester hydrochloride; N-[4-(3-O-Methyl-beta-L-fucopyranosyloxy)p; Afeletecan hydrochloride; BAY 38-3441; L-Valine, N- ( ( (4- ( (6-deoxy-3-O-methyl-beta-L-galactopyranosyl) oxy) phenyl) amino) thioxomethyl) -L-histidyl-, (4S)-4-ethyl-3,4,12,14-tetrahydro-3,14-dioxo-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinolin-4-yl ester, hydrochloride (1:1); 215604-75-4 (BAY 56-3722 free base); 215604-74-3 (BAY 56-3722 HCl salt; 215604-66-3 (diastereomeric mixture). Grades: >98%. CAS No. 215604-74-3. Molecular formula: C45H49N7O11S.HCl. Mole weight: 932.447. BOC Sciences 11

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