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| Product | Description | |
|---|---|---|
| Beclabuvir | Beclabuvir is an allosteric inhibitor that binds to thumb site 1 of the hepatitis C virus ( HCV ) NS5B RNA-dependent RNA polymerase, and inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 with IC 50 of < 28 nM [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-791325. CAS No. 958002-33-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12429. |  |
| Beclabuvir | Beclabuvir is a potent, non-nucleotide inhibitor of HCV NS5B which is currently in Phase III clinical trials for the treatment of chronic HCV infection. Beclabuvir is a thumb site 1-NS5B polymerase ligand. Beclabuvir has been shown to equally inhibit de novo and primer dependent synthesis, 5-75 fold more potently than previously studied compounds, thus resulting the most effective thumb site 1 inhibitor of genotype 1 (GT-1) NS5B polymerase. Synonyms: (4bS, 5aR)-12-cyclohexyl-N-(N, N-dimethylsulfamoyl)-3-methoxy-5a-((1R, 5S)-3-methyl-3, 8-diazabicyclo[3.2.1]octane-8-carbonyl)-4b, 5, 5a, 6-tetrahydrobenzo[3, 4]cyclopropa[5, 6]azepino[1, 2-a]indole-9-carboxamide hydrochloride; BMS791325; BMS-791325; BMS 791325. Grades: 99.87%. CAS No. 958002-33-0. Molecular formula: C36H45N5O5S. Mole weight: 659.84. |  |
| BMS-791325 HCl | BMS-791325 HCl is an allosteric inhibitor that binds to thumb site 1 of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase. BMS-791325 inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 at 50% inhibitory concentrations (IC50 < 28 nM). In cell culture, BMS-791325 inhibited replication of HCV subgenomic replicons representing genotypes 1a and 1b at 50% effective concentrations (EC50s) of 3 nM and 6 nM, respectively, with similar (3 to 18 nM) values for genotypes 3a, 4a, and 5a. BMS-791325 was found to have distinguishing antiviral, safety, and pharmacokinetic properties that resulted in its selection for clinical evaluation. BMS-791325 is currently under Phase III trials. Synonyms: Beclabuvir hydrochloride; BMS-791325 HCl; BMS 791325 HCl; BMS791325 HCl. Grades:> 98%. CAS No. 958002-36-3. Molecular formula: C36H46ClN5O5S. Mole weight: 696.304. | |
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