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| Product | Description | |
|---|---|---|
| Bedaquiline | 5mg Pack Size. Group: Bioactive Small Molecules, Building Blocks, Research Organics & Inorganics. Formula: C32H31BrN2O2. CAS No. 843663-66-1. Prepack ID 90024262-5mg. Molecular Weight 555.5047. See USA prepack pricing. |  |
| Bedaquiline | Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting of both the c- and the ε-subunit [1]. Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-agent resistant tuberculosis [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TMC207; R207910. CAS No. 843663-66-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14881. |  |
| Bedaquiline | TMC207 is a first-in-class diarylquinoline compound with a novel mechanism of action, the inhibition of bacterial ATP synthase, and potent activity against drug-sensitive and drug-resistant TB. Synonyms: Sirturo; TMC207; TMC-207; TMC 207; R207910; R-207910; R 207910. Grades: 98%. CAS No. 843663-66-1. Molecular formula: C32H31BrN2O2. Mole weight: 555.5. |  |
| Bedaquiline fumarate | Bedaquiline fumarate, a diarylquinoline antibiotic that targets ATP synthase, is effective for the treatment of Mycobacterium tuberculosis infections. Uses: Scientific research. Group: Signaling pathways. Alternative Names: R403323; TMC207 fumarate; R207910 fumarate. CAS No. 845533-86-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14881A. | |
| Bedaquiline fumarate | Bedaquiline fumarate is an anti-tuberculosis drug which selectively inhibits the mycobacterial energy metabolism and found to be effective against all states of Mycobacterium tuberculosis. It possesses a unique mechanism of action that disrupts the activity of the mycobacterial adenosine triphosphate synthase. It has an excellent in vitro activity against Mycobacterium tuberculosis, including multidrug resistant M tuberculosis, however, its side effect profile limits its use against MDR-TB when no other effective regimen can be provided. Uses: Antitubercular agents. Synonyms: (1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-naphthalen-1-yl-1-phenylbutan-2-ol fumarate. Grades: >98%. CAS No. 845533-86-0. Molecular formula: C36H35BrN2O6. Mole weight: 671.58. | |
| Bedaquiline Impurity 10 | Bedaquiline Impurity 10. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (E)-4-(6-bromo-2-methoxyquinolin-3-yl)-N,N-dimethyl-3-(naphthalen-1-yl)-4-phenylbut-2-en-1-amine. CAS No. 1032468-56-6. Molecular formula: C32H29BrN2O. Mole weight: 537.49. Catalog: APB1032468566. |  |
| Bedaquiline Impurity 11 | Bedaquiline Impurity 11. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (Z)-4-(6-bromo-2-methoxyquinolin-3-yl)-N,N-dimethyl-3-(naphthalen-1-yl)-4-phenylbut-3-en-1-amine. CAS No. 1032468-55-5. Molecular formula: C32H29BrN2O. Mole weight: 537.49. Catalog: APB1032468555. | |
| Bedaquiline Impurity 37 | Bedaquiline Impurity 37. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1228594-69-1. Molecular formula: C31H28BrClN2O. Mole weight: 559.93. Catalog: APB1228594691. | |
| Bedaquiline (Mixture of Diastereomers) | Bedaquiline is a diarylquinoline derivative that acts as a mycobacterial inhibitor. Bedaquiline shows promise as potential drug in the treatment of tuberculosis. Group: Biochemicals. Alternative Names: 6-Bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl- β-phenyl-3-quinolineethanol. Grades: Highly Purified. CAS No. 654655-80-8. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| (αR, βS)-rel-Bedaquiline | (αR, βS)-rel-Bedaquiline is a promising diarylquinoline candidate in clinical development for the treatment of tuberculosis. (αR, βS)-rel-Bedaquiline inhibits mycobacterial ATP synthase and displays high activity against both drug-susceptible and multidrug-resistant strains of Mycobacterium tuberculosis. Group: Biochemicals. Alternative Names: (αR, βS)-rel-6-Bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl- β-phenyl-3-quinolineethanol. Grades: Highly Purified. CAS No. 654653-93-7. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| (αS, βR)-Bedaquiline | (αS, βR)-Bedaquiline. Group: Biochemicals. Alternative Names: (αS, βR)-6-Bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl- β-phenyl-3-Quinolineethanol. Grades: Highly Purified. CAS No. 843663-66-1. Pack Sizes: 5mg. Molecular Formula: C32H31BrN2O2, Molecular Weight: 555.5. US Biological Life Sciences. | Worldwide |
| rac-N-Desmethyl Bedaquiline | rac-N-Desmethyl Bedaquiline is an intermediate used in th synthesis of Bedaquiline, a medication approved for the treatment of active tuberculosis. Synonyms: N-Monodesmethyl bedaquiline. CAS No. 654654-76-9. Molecular formula: C31H29BrN2O2. Mole weight: 541.5. | |
| 6-Bromo-2-methoxy-3-benzylquinoline | 6-Bromo-2-methoxy-3-benzylquinoline is a reactant used in the preparation of Bedaquiline (B119550), a potential drug in the treatment of tuberculosis. Group: Biochemicals. Alternative Names: 6-Bromo-2-methoxy-3-(phenylmethyl)-quinoline; 3-Benzyl-6-bromo-2-methoxyquinoline. Grades: Highly Purified. CAS No. 654655-69-3. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| TBA-354 | TBA-354 is narrow spectrum and bactericidal in vitro against replicating and nonreplicating Mycobacterium tuberculosis, with potency similar to that of delamanid and greater than that of PA-824. TBA-354 maintains activity against Mycobacterium tuberculosis H37Rv isogenic monoresistant strains and clinical drug-sensitive and drug-resistant isolates. TBA-354 is 5 to 10 times more potent than PA-824, but selected mutants are cross-resistant to PA-824 and delamanid. TBA-354 is 2 to 4 times more potent than PA-824 when combined with bedaquiline, and when administered at a dose equivalent to that of PA-824, TBA-354 demonstrated superior sterilizing efficacy. TBA-354 has high bioavailability and a long elimination half-life. In vitro studies suggest a low risk of drug-drug interactions. Low-dose aerosol infection models of acute and chronic murine tuberculosis reveal time- and dose-dependent in vivo bactericidal activity that is at least as potent as that of delamanid and more potent than that of PA-824. Synonyms: TBA-354, TBA 354, TBA354, SN31354, SN-31354, SN 31354. Grades: >98%. CAS No. 1257426-19-9. Molecular formula: C19H15F3N4O5. Mole weight: 436.34. | |
| TBAJ-876 | TBAJ-876 is the inhibitor of mycobacterium tuberculosis. TBAJ-876 is the analogue of the anti-tuberculosis agent Bedaquiline. TBAJ-876 has the potential for the research of tuberculosis [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2332841-25-3. Pack Sizes: 1 mg. Product ID: HY-128866. | |
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