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| Product | Description | |
|---|---|---|
| Begacestat | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| Begacestat | Begacestat (GSI-953) is a selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase (IC 50 Aβ 40 =15 nM) for the treatment of Alzheimer's disease [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GSI-953. CAS No. 769169-27-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14175. |  |
| Begacestat | Begacestat is a selective thiophene sulfonamide inhibitor of amyloid precursor protein γ-secretase. Begacestat inhibits Abeta production with low nanomolar potency in cellular and cell-free assays of γ-secretase function. In Sep 2010, Phase-I for Alzheimer's disease in USA was discontinued. Uses: Alzheimer's disease. Synonyms: 5-Chloro-N-[(1S)-3,3,3-trifluoro-1-(hydroxymethyl)-2-(trifluoromethyl)propyl]-2-thiophenesulfonamide; Begacestat; GSI-953; GSI953; GSI 953. Grades: 98%. CAS No. 769169-27-9. Molecular formula: C9H8ClF6NO3S2. Mole weight: 391.74. |  |
| GSI-953 | Begacestat (GSI-953) is a selective β-secretase inhibitor that selectively inhibits cleavage of APP over Notch. GSI-953 is used for treating diseases such as cancer in relation to prevention of intestinal secretory metaplasia. Group: Biochemicals. Alternative Names: 5-Chloro-N-[ (1S) -3, 3, 3-trifluoro-1- (hydroxymethyl) -2- (trifluoromethyl) propyl]-2-thiophenesulfonamide; Begacestat; GSI 953. Grades: Highly Purified. CAS No. 769169-27-9. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
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