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Bisantrene dihydrochloride ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. Alfa Chemistry Analytical Products 3
Bisantrene dihydrochloride Bisantrene dihydrochloride is a highly effective antitumor agent, it exerts its cytotoxicity by affecting DNA intercalation. Bisantrene dihydrochloride targets eukaryotic type II topoisomerases. Bisantrene dihydrochloride is a substrate of MDR1 [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CL-216942 dihydrochloride. CAS No. 71439-68-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100875A. MedChemExpress MCE
Bisantrene dihydrochloride Bisantrene dihydrochloride is a highly effective antitumor agent, it exerts its cytotoxicity by affecting DNA intercalation. Bisantrene dihydrochloride targets eukaryotic type II topoisomerases. Bisantrene dihydrochloride is a substrate of MDR1. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Bisantrene hydrochloride;9,10-Anthracenedicarboxaldehyde bis(2-imidazolin-2-ylhydrazone) dihydrochloride;Bisantrene dihydrochloride. Product Category: Inhibitors. Appearance: Solid. CAS No. 71439-68-4. Molecular formula: C22H22N8.2(HCl). Mole weight: 471.39. Purity: 0.9886. Canonical SMILES: [H]Cl.[H]Cl.C12=CC=CC=C1C(/C=N/NC3=NCCN3)=C4C(C=CC=C4)=C2/C=N/NC5=NCCN5. Product ID: ACM71439684. Alfa Chemistry — ISO 9001:2015 Certified. Alfa Chemistry.
Bisantrene Dihydrochloride Bisantrene Dihydrochloride is the hydrochloride salt of Bisantrene. Bisantrene, also referred to CL-216942, Cyabin or NSC-337766, an anthracene bishydrazone derivative, is a topoisomerase II poison and can intercalate into the DNA of tumor cells. Bisantrene leads to DNA single-strand breaks, DNA-protein crosslinking, and inhibition of DNA replication by intercalating with and disrupting the configuration of DNA. Bisantrene is an anthracycline chemotherapy agent notably for AML (Acute Myeloid Leukaemia), but one of the drawbacks of anthracycline chemotherapy agents like doxorubicin is their risk of cardiac toxicity and consequent heart failure. Bisantrene has been shown to have greatly reduced cardiac toxicity with similar antineoplastic activity. Uses: Antibiotics, antineoplastic. Synonyms: N-[(E)-[10-[(E)-(4,5-dihydro-1H-imidazol-2-ylhydrazinylidene)methyl]anthracen-9-yl]methylideneamino]-4,5-dihydro-1H-imidazol-2-amine; dihydrochloride; 9,10-anthracenedicarboxaldehyde bis(4,5-dihydro-1H-imidazol-2-yl)hydrazone; bisantrene; bisantrene dihydrochloride; CL 216942; CL216,942; NSC 337766. CAS No. 71439-68-4. Molecular formula: C22H24Cl2N8. Mole weight: 471.39. BOC Sciences 6

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