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| Product | Description | |
|---|---|---|
| Bisindolylmaleimide I | Bisindolylmaleimide I (GF109203X) is a cell-permeable and reversible PKC inhibitor ( IC 50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKC&gamma. Bisindolylmaleimide I is also a GSK-3 inhibitor [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GF109203X; Go 6850. CAS No. 133052-90-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13867. |  |
| Bisindolylmaleimide I | Cell permeable kinase inhibitor with improved selectivity for protein kinase C (PKC) (Ki = 10 nM). Competetive inhibitor for the ATP-binding site of PKC. Anti-inflammatory. Binds to P-glycoprotein. Telomerase activity inhibitor. Potent glycogen synthase kinase-3 (GSK-3) inhibitor. Necrosis inhibitor. Blocks hERG potassium channels. Group: Biochemicals. Alternative Names: GF-109203X, Gö 6850, BIM I. Grades: Highly Purified. CAS No. 133052-90-1. Pack Sizes: 1mg, 5mg. Molecular Formula: C25H24N4O2. US Biological Life Sciences. |  Worldwide |
| Bisindolylmaleimide I hydrochloride | Bisindolylmaleimide I (GF109203X) hydrochloride is a cell-permeable and reversible PKC inhibitor ( IC 50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKC&gamma. Bisindolylmaleimide I hydrochloride is also a GSK-3 inhibitor [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GF109203X hydrochloride; Go 6850 hydrochloride. CAS No. 176504-36-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-13867A. | |
| Bisindolylmaleimide I hydrochloride | Bisindolylmaleimide I hydrochloride (BMI) is a water soluble form of Bisindolylmaleimide I. It is a staurosporine inspired molecule, which has been shown to display equally potent inhibition. BIM I is a highly selective, cell-permeable, and reversible PKC inhibitor with Ki of 14 nM that is structurally similar to the poorly selective PKC inhibitor staurosporine. This compound has been used to selectively probe for PKC-mediated pathways for transduction of hormone, cytokine, and growth factor signals. It can inhibit PKC (protein kinase C) within intact platelets and T cells, Fas-mediated apoptosis, and T cell-mediated autoimmune diseases. Synonyms: BIM I; GF109203X; Gö 6850. Grades: ≥98%. CAS No. 176504-36-2. Molecular formula: C25H24N4O2·HCl. Mole weight: 449. |  |
| Bisindolylmaleimide I hydrochloride | Cell permeable kinase inhibitor with improved selectivity for protein kinase C (PKC) (Ki = 10 nM). Competitive inhibitor for the ATP-binding site of PKC. Anti-inflammatory. Binds to P-glycoprotein. Telomerase activity inhibitor. Potent glycogen synthase kinase-3 (GSK-3) inhibitor. Necrosis inhibitor. Blocks hERG potassium channels. Group: Biochemicals. Alternative Names: GF 109203X, Gö 6850, BIM I. Grades: Highly Purified. CAS No. 176504-36-2. Pack Sizes: 1mg, 5mg. Molecular Formula: C25H24N4O2. HCl. US Biological Life Sciences. | Worldwide |
| Bisindolylmaleimide I, Hydrochloride - CAS 176504-36-2 | An enhanced water-soluble form of Bisindolylmaleimide I. Group: Fluorescence/luminescence spectroscopy. |  |
| Bisindolylmaleimide II | ?97% (Mixture of 2 isomers). Group: Fluorescence/luminescence spectroscopy. | |
| Bisindolylmaleimide II | Bisindolylmaleimide II is a general inhibitor of all PKC subtypes [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Bis II. CAS No. 137592-45-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-108604. | |
| Bisindolylmaleimide II | Bisindolylmaleimide II is a potent and ATP-competitive inhibitor of protein kinase C (PKC) (IC50 = 0.01 μM). It also displays an antagonistic effect on nicotinic cholinergic receptors (IC50 ~ 0.03 μM for inhibition of catecholamine secretion in nicotine-stimulated PC-12 cells) and an inhibitory effect on PDK1 (IC50 = 14 μM). Synonyms: 3-(1H-Indol-3-yl)-4-[1-[2-(1-methyl-2-pyrrolidinyl)ethyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione. Grades: ≥97% by HPLC. CAS No. 137592-45-1. Molecular formula: C27H26N4O2. Mole weight: 438.52. | |
| Bisindolylmaleimide II | Protein kinase C (PKC) inhibitor. Binds with reversed orientation to protein kinase A (PKA). Group: Biochemicals. Grades: Highly Purified. CAS No. 137592-45-1. Pack Sizes: 1mg, 5mg. Molecular Formula: C27H26N4O2. US Biological Life Sciences. | Worldwide |
| Bisindolylmaleimide III | Bisindolylmaleimide III is a potent and selective inhibitor of PKC (protein kinase C) with structural similarity to the nonspecific PKC inhibitor staurosporine. It inhibits 93% of PKCα kinase activity and also inhibits many other protein kinases including, S6K1, MAPKAP-K1, RSK2 and MSK1. Synonyms: BIM III. Grades: ≥98%. CAS No. 137592-43-9. Molecular formula: C23H20N4O2. Mole weight: 384.4. | |
| Bisindolylmaleimide III | Potent and selective protein kinase C (PKC) inhibitor. Inhibits panel of protein kinases (e.g. GSK-3beta, CDK2). Group: Biochemicals. Grades: Highly Purified. CAS No. 137592-43-9. Pack Sizes: 1mg, 5mg. Molecular Formula: C23H20N4O2. US Biological Life Sciences. | Worldwide |
| Bisindolylmaleimide IV | ?98% (TLC), solid. Group: Fluorescence/luminescence spectroscopy. | |
| Bisindolylmaleimide IV | Cell permeable protein kinase C (PKC) inhibitor. Inhibits also protein kinase A (PKA). Group: Biochemicals. Alternative Names: Ro 31-6233, Arcyriarubin A, BIM IV, 2,3-bis(1H-Indol-3-yl)maleimide. Grades: Highly Purified. CAS No. 119139-23-0. Pack Sizes: 1mg, 5mg. Molecular Formula: C20H13N3O2. US Biological Life Sciences. | Worldwide |
| Bisindolylmaleimide IV - CAS 119139-23-0 | A potent, cell permeable, and selective inhibitor of protein kinase C (IC?? = 87 nM). Group: Fluorescence/luminescence spectroscopy. | |
| Bisindolylmaleimide IX methanesulfonate | Selective and cell permeable protein kinase C (PKC) inhibitor. Inhibits the stimulation of insulin secretion by glucose. Inhibits T cell activation. Apoptosis inducer. Potent glycogen synthase kinase-3 (GSK-3) inhibitor. Transcription inhibitor. Induces TNF receptor family-mediated cell death. Pim-1 kinase inhibitor. Antitumor compound. Group: Biochemicals. Grades: Highly Purified. CAS No. 138489-18-6. Pack Sizes: 1mg, 5mg. Molecular Formula: C25H23N5O2S CH4O3S. US Biological Life Sciences. | Worldwide |
| Bisindolylmaleimide V | Bisindolylmaleimide IV (BIM IV) is a cell-permeable inhibitor of protein kinase C (PKC) with IC50 of 0.10-0.55 μM. It is a weak inhibitor of protein kinase C (PKC) demonstrating an IC50 value >100 μM. BIM IV also inhibits protein kinase A with IC50 of 2-11.8 μM. Bisindolylmaleimide V is used as a negative control for the PKC (protein kinase C)-inhibitory activity. Synonyms: BIM V; Ro 31-6045. Grades: ≥98%. CAS No. 113963-68-1. Molecular formula: C21H15N3O2. Mole weight: 341.3. | |
| Bisindolylmaleimide V | Negative control for protein kinase C (PKC) inhibitors. S6K inhibitor. Necrosis inhibitor. A cell-permeable negative control compound for protein kinase C inhibition studies (IC50 > 100uM). Blocks the activation of p70s6k/p85s6k in vivo (IC50 = 8uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 113963-68-1. Pack Sizes: 1mg, 5mg. Molecular Formula: C21H15N3O2, Molecular Weight: 341.4. US Biological Life Sciences. | Worldwide |
| Bisindolylmaleimide V - CAS 113963-68-1 | A cell-permeable negative control compound for protein kinase C inhibition studies (IC?? >100 μM). Group: Fluorescence/luminescence spectroscopy. | |
| Bisindolylmaleimide vii | Bisindolylmaleimide vii. Uses: Designed for use in research and industrial production. Additional or Alternative Names: BISINDOLYLMALEIMIDE VII. Product Category: Heterocyclic Organic Compound. Appearance: Orange solid. CAS No. 137592-47-3. Molecular formula: C27H27N5O2. Mole weight: 453.54. Purity: >96%. IUPACName: 3-(1H-indol-3-yl)-4-[1-(3-piperazin-1-ylpropyl)indol-3-yl]pyrrole-2,5-dione. Canonical SMILES: C1CN(CCN1)CCCN2C=C(C3=CC=CC=C32)C4=C(C(=O)NC4=O)C5=CNC6=CC=CC=C65. Product ID: ACM137592473. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Bisindolylmaleimide VII | 96% (TLC), solid. Group: Fluorescence/luminescence spectroscopy. | |
| Bisindolylmaleimide VIII acetate | Bisindolylmaleimide VIII (BIM VIII) is a selective protein kinase C (PKC) inhibitor with IC50 of 158 nM for rat brain that acts at the ATP binding site. Bis VIII has been previously shown to enhance Fas-mediated apoptosis through a protein kinase C-independent mechanism. BIM VIII does not inhibit the tyrosine phosphorylation or the activation of phospholipase C γ1. BIM VIII inhibits carbachol-evoked noradrenaline release from human SH-SY5Y neuroblastoma cells with an IC50 of 600 nM. Synonyms: BIM VIII; Ro 31-7549. Grades: ≥98%. CAS No. 138516-31-1. Molecular formula: C24H22N4O2·C2H4O2. Mole weight: 458.5. | |
| Bisindolylmaleimide VIII acetate | Selective protein kinase C (PKC) inhibitor. Inhibits proliferation of cultured mouse epidermal keratinocytes. Enhances Fas- and TRAIL-mediated apoptosis. Inhibits T cell-mediated autoimmune diseases. Inhibits stimulation of insulin secretion by glucose. Inhibits panel of protein kinases (e.g. GSK-3beta, CDK2). Group: Biochemicals. Alternative Names: Ro 31-7549, BIM VIII. Grades: Highly Purified. CAS No. 138516-31-1. Pack Sizes: 1mg, 5mg. Molecular Formula: C24H22N4O2. CH3COOH. US Biological Life Sciences. | Worldwide |
| Bisindolylmaleimide X hydrochloride | ?90%, solid. Group: Fluorescence/luminescence spectroscopy. | |
| Bisindolylmaleimide X hydrochloride | Bisindolylmaleimide X hydrochloride is a potent and selective cell-permeable protein kinase C (PKC) inhibitor with IC50 of 15 nM for rat brain PKC. It has also been identified as an inhibitor of Cdk2 with IC50 of 200. It has been used to activate mesenchymal stem cells, which increases the surface expression of homing ligands that bind to intercellular adhesion molecule and target delivery of these cells to sites of inflammation. Uses: Enzyme inhibitors. Synonyms: BIM X; Ro 31-8425. Grades: ≥98%. CAS No. 145317-11-9. Molecular formula: C26H24N4O2·HCl. Mole weight: 461. | |
| Bisindolylmaleimide X hydrochloride | Selective protein kinase C (PKC) inhibitor. Inhibits panel of protein kinases (e.g. GSK-3beta, CDK2). Inhibits superoxide generation in human neutrophils. Group: Biochemicals. Alternative Names: Ro 31-8425, BIM X. Grades: Highly Purified. CAS No. 131848-97-0, 145317-11-9. Pack Sizes: 1mg, 5mg. Molecular Formula: C26H24N4O2 HCl. US Biological Life Sciences. | Worldwide |
| Bisindolylmaleimide XI hydrochloride | ?98% (TLC), solid. Group: Fluorescence/luminescence spectroscopy. | |
| Bisindolylmaleimide XI hydrochloride | Bisindolylmaleimide XI hydrochloride is a cell-permeable selective inhibitor of PKC displaying a 10-fold greater selectivity for PKCα with IC50 of 9.3 nM. It is a 4-fold greater selectivity for PKC-βI over PKCε with IC50 of 108 nM. It prevents T cell-driven chronic inflammatory responses in several rat models. Synonyms: BIM XI; Ro 31-0432. Grades: ≥98%. CAS No. 145333-02-4. Molecular formula: C28H28N4O2·HCl. Mole weight: 489. | |
| Bisindolylmaleimide XI Hydrochloride | Selective cell permeable protein kinase C (PKC) inhibitor. G protein-coupled receptor kinase (GRK-5) inhibitor. Less potent GRK-2 or GRK-3 inhibitor. Prevents T cell-driven chronic inflammatory responses in vivo. Group: Biochemicals. Alternative Names: Ro 32-0432, BIM XI. Grades: Highly Purified. CAS No. 145333-02-4. Pack Sizes: 1mg, 5mg. Molecular Formula: C28H28N4O2 HCl. US Biological Life Sciences. | Worldwide |
| 3,4-Di(1H-indol-3-yl)-1H-pyrrole-2,5-dione | 3,4-Di(1H-indol-3-yl)-1H-pyrrole-2,5-dione. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 2,3-bis(1H-Indol-3-yl)maleimide; J-004072; DTXSID30152324; BRD-K49448285-001-01-3; DS-0027; AC1L1DL8; CCG-206739; AX8117363; Ro-31-6233; Bisindolyl deriv. 3. Product Category: Heterocyclic Organic Compound. CAS No. 119139-23-0. Molecular formula: C20H13N3O2. Mole weight: 327.343g/mol. IUPACName: 3,4-bis(1H-indol-3-yl)pyrrole-2,5-dione. Canonical SMILES: C1=CC=C2C(=C1)C(=CN2)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54. Product ID: ACM119139230. Alfa Chemistry ISO 9001:2015 Certified. Categories: bisindolylmaleimide iv. | |
| 3,4-Di(3-indolyl)-1H-pyrrole-2,5-dione | Bisindolylmaleimide IV (BIM IV) is an inhibitor of pyruvate phosphate dikinase (PPDK). It is a cell-permeable potent and somewhat selective inhibitor of PKC with IC50 of 87 nM. BIM IV is a cell-permeable inhibitor of protein kinase C (PKC) with IC50 values reported to range from 0.10 to 0.55 μM. It also inhibits protein kinase A (PKA) with an IC50 of 2.7 μM. Synonyms: 3,4-bis(1H-indol-3-yl)pyrrole-2,5-dione; 3,4-bis(1H-indol-3-yl)pyrrole-2,5-dione. Grades: > 98 %. CAS No. 119139-23-0. Molecular formula: C20H13N3O2. Mole weight: 327.34. | |
| GF-109203X | GF-109203X is a potent and highly selective PCK inhibitor, which inhibits PKC isozymes alpha, beta 1, beta 2, gamma, delta and epsilon in vitro. GF-109203X inhibited GSK-3 in vitro, when assayed either in cell lysates (IC(50) 360 nM or in GSK-3beta immunoprecipitates (IC(50) 170 nM derived from rat epididymal adipocytes. Pretreatment of adipocytes with GF-109203X (5 microM) reduced GSK-3 activity in total cell lysates, to 25.1+/-4.3% of control. Synonyms: GF109203X; GF 109203X; Bisindolylmaleimide i; GO 6850; GO-6850; GO6850; 2-[1-(3-dimethylaminopropyl)indol-3-yl]-3-(indol-3-yl)maleimide. Grades: ≥98%. CAS No. 133052-90-1. Molecular formula: C25H24N4O2. Mole weight: 412.49. | |
| MKC-1 | MKC-1 is an orally bioavailable, small-molecule, bisindolylmaleimide cell cycle inhibitor with potential antineoplastic activity. MKC-1 and its metabolites inhibit tubulin polymerization, blocking the formation of the mitotic spindle, which may result in cell cycle arrest at the G2/M phase and apoptosis. In addition, this agent has been shown to inhibit the activities of the oncogenic kinase Akt, the mTOR pathway, and importin-beta, a protein essential to the transport of other proteins from the cytosol into the nucleus. Synonyms: MKC1; MKC 1; R 440; Ro 317453; Ro-317453; Ro317453; 3-(1-methyl-1H-indol-3-yl)-4-(1-methyl-6-nitro-1H-indol-3-yl)-1H-pyrrole-2,5-dione. CAS No. 125313-92-0. Molecular formula: C22H16N4O4. Mole weight: 400.39. | |
| MKC-1 | MKC-1 is an orally bioavailable, small-molecule, bisindolylmaleimide cell cycle inhibitor with potential antineoplastic activity. MKC-1 and its metabolites inhibit tubulin polymerization, blocking the formation of the mitotic spindle, which may result in cell cycle arrest at the G2/M phase and apoptosis. Uses: Designed for use in research and industrial production. Additional or Alternative Names: MKC1; MKC 1; MKC-1; R 440; R-440; R440; Ro 317453; Ro-317453; Ro317453. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 125313-92-0. Molecular formula: C22H16N4O4. Mole weight: 400.39. Purity: >98%. IUPACName: 3-(1-methyl-1H-indol-3-yl)-4-(1-methyl-6-nitro-1H-indol-3-yl)-1H-pyrrole-2,5-dione. Canonical SMILES: O=C(C(C1=CN(C)C2=C1C=CC=C2)=C3C4=CN(C)C5=C4C=CC([N+]([O-])=O)=C5)NC3=O. Product ID: ACM125313920. Alfa Chemistry ISO 9001:2015 Certified. Categories: Mk 153 Shoulder-Launched Multipurpose Assault Weapon. | |
| Ro 31-8220 Mesylate | Ro 31-8220 inhibits rat brain PKC activity with IC50 of 23 nM, and does not show any high degree of selectivity between PKC-α, PKC-β, PKC-γ, and PKC-&epsilon. Synonyms: RO31-8220; RO 31-8220; RO31-8220; RO318220; RO-318220; RO 318220; RO31-8220 mesylate; Bisindolylmaleimide IX; BIM IX.Bisindolylmaleimide IX Mesylate. Grades: >98%. CAS No. 138489-18-6. Molecular formula: C25H23N5O2S.CH4O3S. Mole weight: 553.65. | |
| Ro 32-0432 hydrochloride | Ro 32-0432 hydrochloride is a selective and orally active inhibitor of PKC displaying a 10-fold greater selectivity for PKC-&alpha (IC50 = 9.3 nM); and a 4-fold greater selectivity for PKC-βI over PKC- &epsilon (IC50 = 108 nM). Synonyms: Ro 32-0432; Ro 320432; Ro-32-0432. 3-[(8S)-8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione hydrochloride; RO 32-0432 HCL; RO 32-0432 HYDROCHLORIDE; BISINDOLYLMALEIMIDE XI, HCL; BISINDOLYLMALEIMIDE XI HYDROCHLORIDE; BISINDOLYLMALEIMIDE XL, HCL; BISINDOYLMALEIMIDE XI HYDROCHLORIDE. Grades: ≥99% by HPLC. CAS No. 151342-35-7. Molecular formula: C28H28N4O2.HCl. Mole weight: 489.01. | |
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