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| Product | Description | |
|---|---|---|
| Bisindolylmaleimide II | ?97% (Mixture of 2 isomers). Group: Fluorescence/luminescence spectroscopy. |  |
| Bisindolylmaleimide II | Bisindolylmaleimide II is a general inhibitor of all PKC subtypes [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Bis II. CAS No. 137592-45-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-108604. |  |
| Bisindolylmaleimide II | Bisindolylmaleimide II is a potent and ATP-competitive inhibitor of protein kinase C (PKC) (IC50 = 0.01 μM). It also displays an antagonistic effect on nicotinic cholinergic receptors (IC50 ~ 0.03 μM for inhibition of catecholamine secretion in nicotine-stimulated PC-12 cells) and an inhibitory effect on PDK1 (IC50 = 14 μM). Synonyms: 3-(1H-Indol-3-yl)-4-[1-[2-(1-methyl-2-pyrrolidinyl)ethyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione. Grades: ≥97% by HPLC. CAS No. 137592-45-1. Molecular formula: C27H26N4O2. Mole weight: 438.52. |  |
| Bisindolylmaleimide II | Protein kinase C (PKC) inhibitor. Binds with reversed orientation to protein kinase A (PKA). Group: Biochemicals. Grades: Highly Purified. CAS No. 137592-45-1. Pack Sizes: 1mg, 5mg. Molecular Formula: C27H26N4O2. US Biological Life Sciences. |  Worldwide |
| Bisindolylmaleimide III | Bisindolylmaleimide III is a potent and selective inhibitor of PKC (protein kinase C) with structural similarity to the nonspecific PKC inhibitor staurosporine. It inhibits 93% of PKCα kinase activity and also inhibits many other protein kinases including, S6K1, MAPKAP-K1, RSK2 and MSK1. Synonyms: BIM III. Grades: ≥98%. CAS No. 137592-43-9. Molecular formula: C23H20N4O2. Mole weight: 384.4. | |
| Bisindolylmaleimide III | Potent and selective protein kinase C (PKC) inhibitor. Inhibits panel of protein kinases (e.g. GSK-3beta, CDK2). Group: Biochemicals. Grades: Highly Purified. CAS No. 137592-43-9. Pack Sizes: 1mg, 5mg. Molecular Formula: C23H20N4O2. US Biological Life Sciences. | Worldwide |
| Bisindolylmaleimide I | Bisindolylmaleimide I (GF109203X) is a cell-permeable and reversible PKC inhibitor ( IC 50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKC&gamma. Bisindolylmaleimide I is also a GSK-3 inhibitor [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GF109203X; Go 6850. CAS No. 133052-90-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13867. | |
| Bisindolylmaleimide I hydrochloride | Bisindolylmaleimide I (GF109203X) hydrochloride is a cell-permeable and reversible PKC inhibitor ( IC 50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKC&gamma. Bisindolylmaleimide I hydrochloride is also a GSK-3 inhibitor [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GF109203X hydrochloride; Go 6850 hydrochloride. CAS No. 176504-36-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-13867A. | |
| Ro 31-8220 mesylate | Ro 31-8220 mesylate is a potent PKC inhibitor, with IC50s of 5, 24, 14, 27, 24 and 23 nM for PKC?, PKC?I, PKC?II, PKC?, PKC? and rat brain PKC, respectively. Ro 31-8220 also significantly inhibits MAPKAP-K1b, MSK1, S6K1 and GSK3? (IC50s, 3, 8, 15, and 38 nM, respectively), with no effect on MKK3, MKK4, MKK6 and MKK7. Ro 31-8220 mesylate can also inhibit the expression of MKP-1, induce the expression of c-Jun, and activate JNK, and these effects possess pharmacological properties independent of PKC[1][2][3][4][5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Ro 31-8220 methanesulfonate; Bisindolylmaleimide IX mesylate. CAS No. 138489-18-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13866. | |
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