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| Product | Description | |
|---|---|---|
| Bisindolylmaleimide V | Bisindolylmaleimide IV (BIM IV) is a cell-permeable inhibitor of protein kinase C (PKC) with IC50 of 0.10-0.55 μM. It is a weak inhibitor of protein kinase C (PKC) demonstrating an IC50 value >100 μM. BIM IV also inhibits protein kinase A with IC50 of 2-11.8 μM. Bisindolylmaleimide V is used as a negative control for the PKC (protein kinase C)-inhibitory activity. Synonyms: BIM V; Ro 31-6045. Grades: ≥98%. CAS No. 113963-68-1. Molecular formula: C21H15N3O2. Mole weight: 341.3. |  |
| Bisindolylmaleimide V | Negative control for protein kinase C (PKC) inhibitors. S6K inhibitor. Necrosis inhibitor. A cell-permeable negative control compound for protein kinase C inhibition studies (IC50 > 100uM). Blocks the activation of p70s6k/p85s6k in vivo (IC50 = 8uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 113963-68-1. Pack Sizes: 1mg, 5mg. Molecular Formula: C21H15N3O2, Molecular Weight: 341.4. US Biological Life Sciences. |  Worldwide |
| Bisindolylmaleimide V - CAS 113963-68-1 | A cell-permeable negative control compound for protein kinase C inhibition studies (IC?? >100 μM). Group: Fluorescence/luminescence spectroscopy. |  |
| Bisindolylmaleimide vii | Bisindolylmaleimide vii. Uses: Designed for use in research and industrial production. Additional or Alternative Names: BISINDOLYLMALEIMIDE VII. Product Category: Heterocyclic Organic Compound. Appearance: Orange solid. CAS No. 137592-47-3. Molecular formula: C27H27N5O2. Mole weight: 453.54. Purity: >96%. IUPACName: 3-(1H-indol-3-yl)-4-[1-(3-piperazin-1-ylpropyl)indol-3-yl]pyrrole-2,5-dione. Canonical SMILES: C1CN(CCN1)CCCN2C=C(C3=CC=CC=C32)C4=C(C(=O)NC4=O)C5=CNC6=CC=CC=C65. Product ID: ACM137592473. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Bisindolylmaleimide VII | 96% (TLC), solid. Group: Fluorescence/luminescence spectroscopy. | |
| Bisindolylmaleimide VIII acetate | Bisindolylmaleimide VIII (BIM VIII) is a selective protein kinase C (PKC) inhibitor with IC50 of 158 nM for rat brain that acts at the ATP binding site. Bis VIII has been previously shown to enhance Fas-mediated apoptosis through a protein kinase C-independent mechanism. BIM VIII does not inhibit the tyrosine phosphorylation or the activation of phospholipase C γ1. BIM VIII inhibits carbachol-evoked noradrenaline release from human SH-SY5Y neuroblastoma cells with an IC50 of 600 nM. Synonyms: BIM VIII; Ro 31-7549. Grades: ≥98%. CAS No. 138516-31-1. Molecular formula: C24H22N4O2·C2H4O2. Mole weight: 458.5. | |
| Bisindolylmaleimide VIII acetate | Selective protein kinase C (PKC) inhibitor. Inhibits proliferation of cultured mouse epidermal keratinocytes. Enhances Fas- and TRAIL-mediated apoptosis. Inhibits T cell-mediated autoimmune diseases. Inhibits stimulation of insulin secretion by glucose. Inhibits panel of protein kinases (e.g. GSK-3beta, CDK2). Group: Biochemicals. Alternative Names: Ro 31-7549, BIM VIII. Grades: Highly Purified. CAS No. 138516-31-1. Pack Sizes: 1mg, 5mg. Molecular Formula: C24H22N4O2. CH3COOH. US Biological Life Sciences. | Worldwide |
| 3,4-Di(3-indolyl)-1H-pyrrole-2,5-dione | Bisindolylmaleimide IV (BIM IV) is an inhibitor of pyruvate phosphate dikinase (PPDK). It is a cell-permeable potent and somewhat selective inhibitor of PKC with IC50 of 87 nM. BIM IV is a cell-permeable inhibitor of protein kinase C (PKC) with IC50 values reported to range from 0.10 to 0.55 μM. It also inhibits protein kinase A (PKA) with an IC50 of 2.7 μM. Synonyms: 3,4-bis(1H-indol-3-yl)pyrrole-2,5-dione; 3,4-bis(1H-indol-3-yl)pyrrole-2,5-dione. Grades: > 98 %. CAS No. 119139-23-0. Molecular formula: C20H13N3O2. Mole weight: 327.34. | |
| GF-109203X | GF-109203X is a potent and highly selective PCK inhibitor, which inhibits PKC isozymes alpha, beta 1, beta 2, gamma, delta and epsilon in vitro. GF-109203X inhibited GSK-3 in vitro, when assayed either in cell lysates (IC(50) 360 nM or in GSK-3beta immunoprecipitates (IC(50) 170 nM derived from rat epididymal adipocytes. Pretreatment of adipocytes with GF-109203X (5 microM) reduced GSK-3 activity in total cell lysates, to 25.1+/-4.3% of control. Synonyms: GF109203X; GF 109203X; Bisindolylmaleimide i; GO 6850; GO-6850; GO6850; 2-[1-(3-dimethylaminopropyl)indol-3-yl]-3-(indol-3-yl)maleimide. Grades: ≥98%. CAS No. 133052-90-1. Molecular formula: C25H24N4O2. Mole weight: 412.49. | |
| Bisindolylmaleimide XI Hydrochloride | Selective cell permeable protein kinase C (PKC) inhibitor. G protein-coupled receptor kinase (GRK-5) inhibitor. Less potent GRK-2 or GRK-3 inhibitor. Prevents T cell-driven chronic inflammatory responses in vivo. Group: Biochemicals. Alternative Names: Ro 32-0432, BIM XI. Grades: Highly Purified. CAS No. 145333-02-4. Pack Sizes: 1mg, 5mg. Molecular Formula: C28H28N4O2 HCl. US Biological Life Sciences. | Worldwide |
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