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| Product | Description | |
|---|---|---|
| BIX | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| BIX | BIX. Group: Biochemicals. Grades: Purified. CAS No. 101714-41-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| BIX | BIX is a BiP (Hsp70-5) ER chaperone inducer that induces BiP expression in vitro and in vivo. BIX protects against ER-stress induced cell death in neuronal and retinal cell lines, and also protects against ischaemia-induced hippocampal cell death in vivo. Synonyms: 2-(3,4-Dihydroxyphenyl)-2-oxoethyl ester thiocyanic acid; Thiocyanic acid,2-(3,4-dihydroxyphenyl)-2-oxoethyl ester. Grades: ≥98% by HPLC. CAS No. 101714-41-4. Molecular formula: C9H7NO3S. Mole weight: 209.22. |  |
| BIX 01294 | Selective and cell permeable G9a histone lysine methyltransferase (HMTase) inhibitor. Pluripotent stem cell inducer. Group: Biochemicals. Alternative Names: 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-4-quinazolinamine. Grades: Highly Purified. CAS No. 935693-62-2. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C28H38N6O2. US Biological Life Sciences. | Worldwide |
| BIX-01294 | BIX-01294, a diazepin-quinazolinamine derivative, is a selective inhibitor of G9a histone methyl transferase (G9a HMTase) that impairs G9a HMTase and generation of H3K9me2 in vitro. It does not compete with cofactor S-adenosyl-methionine. It enhances reprogramming efficiency of neural progenitor cells to the same levels as when four transcription factors (Oct4, Klf4, Sox2 and c-Myc) were introduced to somatic cells for generation of induced pluripotent stem cells. It may replace the requirement for ectopic OCT4 (POU5F1) and cMyc respectively in pluripotent stem cell induction (iPS). Synonyms: BIX-01294; BIX 01294; BIX01294. Grades: >98%. CAS No. 935693-62-2. Molecular formula: C28H38N6O2. Mole weight: 490.64. | |
| BIX01294 hydrochloride hydrate | Histone methyltransferases (HMT) are histone-modifying enzymes (e.g., histone-lysine N-methyltransferases and histone-arginine N-methyltransferases) that catalyze the transfer of one, two, or three methyl groups to lysine and arginine residues of histone proteins. BIX 01294 is a diazepin-quinazolinamine derivate and G9a histone methyltransferase inhibitor with IC50 of 1.9 μM and GLP inhibitor with IC50 of 0.7 μM. It less effectively inhibits the HMTase G9a-like protein and has no effect on other known HMTases. BIX 01294 was reported to function by blocking the histone binding sites. It modulates the epigenetic status of chromatin and has been used to improve the reprogramming efficiency of iPSC generation. Synonyms: BIX 01294; BIX-01294. Grades: ≥98%. CAS No. 1808255-64-2. Molecular formula: C28H38N6O2·3HCl·xH2O. Mole weight: 600. | |
| BIX 01294 trihydrochloride | BIX 01294 is a G9a histone methyltransferase inhibitor. It enhances the induction of pluripotent stem cells from somatic cells in vitro. BIX-01294 trihydrochloride induces necroptosis and autophagy. Synonyms: BIX 01294 trihydrochloride; BIX-01294; N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine trihydrochloride. Grades: >98%. CAS No. 1392399-03-9. Molecular formula: C28H41Cl3N6O2. Mole weight: 600.02. | |
| BIX 01294 Trihydrochloride | G9a-like protein and G9a histone lysine methyltransferase (HMTase) inhibitor that H3K9me2 chromatin levels modulates H3K9me2 levels in mammalian cells and potentiates induction of pluripotent stem cells from somatic cells in vitro. Group: Biochemicals. Alternative Names: 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine Trihydrochloride. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| BIX 01294 trihydrochloride hydrate | ?98% (HPLC), powder. Group: Fluorescence/luminescence spectroscopy. | |
| BIX-01338 hydrate | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| BIX-01338 hydrate | BIX-01338 hydrate is a histone lysine methyltransferase inhibitor. Uses: Scientific research. Group: Signaling pathways. CAS No. 1228184-65-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12991A. |  |
| BIX02188 | BIX02188. Group: Biochemicals. Alternative Names: 3- [ [ [3- [ (Dimethylamino) methyl] phenyl] amino] phenylmethylene] -2, 3-dihydro-2-oxo-1H-indole-6-carboxamide. Grades: Highly Purified. CAS No. 1094614-84-2. Pack Sizes: 10mg. Molecular Formula: C25H24N4O2, Molecular Weight: 412.48. US Biological Life Sciences. | Worldwide |
| BIX-02188 | BIX02188 is a potent MEK5-selective inhibitor with an IC50 of 4.3 nM. BIX02188 inhibits ERK5 catalytic activity, with an IC50 of 810 nM. Synonyms: BIX02188; BIX-02188; BIX 02188. CAS No. 334949-59-6. Molecular formula: C25H24N4O2. Mole weight: 412.493. | |
| BIX02189 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| BIX02189 | BIX02189. Group: Biochemicals. Alternative Names: 3- [ [ [3- [ (Dimethylamino) methyl] phenyl] amino] phenylmethylene] -2, 3-dihydro-N, N-dimethyl-2-oxo-1H-indole-6-carboxamide. Grades: Highly Purified. CAS No. 1094614-85-3. Pack Sizes: 5mg. Molecular Formula: C27H28N4O2, Molecular Weight: 440.54. US Biological Life Sciences. | Worldwide |
| BIX 02189 | BIX 02189. Group: Biochemicals. Grades: Purified. CAS No. 1265916-41-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| BIX 02189 | BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM, also inhibits ERK5 catalytic activity with IC50 of 59 nM, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2. Synonyms: BIX02189; BIX-02189; (Z)-3- ( (3- ( (dimethylamino)methyl)phenylamino) (phenyl)methylene)-N, N-dimethyl-2-oxoindoline-6-carboxamide. Grades: >98%. CAS No. 1094614-85-3. Molecular formula: C27H28N4O2. Mole weight: 440.54. | |
| BIX 02565 | BIX 02565, a RSK2 inhibitor, has also been found to significanltly influence sorts of adrenergic receptor subtypes involved in ascular tone and cardiac function. IC50: 1.1 nM (RSK2). Uses: Bix 02565 is a rsk2 inhibitor that has also been found to significanltly influence sorts of adrenergic receptor subtypes involved in ascular tone and cardiac function. Synonyms: BIX 02565; BIX02565; CHEMBL1933288; BIX02565; GTPL8039; SCHEMBL1980595; BDBM50360301. Grades: 97%. CAS No. 1311367-27-7. Molecular formula: C26H30N6O2. Mole weight: 458.56. | |
| Bixafen | analytical standard. Group: Pesticides & metabolites standardspesticides & metabolitespesticides & metabolites. | |
| Bixafen Metabolite BYF00587 | analytical standard. Group: Pesticides & metabolites standards. | |
| Bixin | Bixin (BX), isolated from the seeds of Bixa orellana , is a carotenoid, possessing anti-inflammatory, anti-tumor and anti-oxidant activities. Bixin treatment ameliorated cardiac dysfunction through inhibiting fibrosis, inflammation and reactive oxygen species ( ROS ) generation [1]. Uses: Scientific research. Group: Natural products. CAS No. 6983-79-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-N6884. | |
| Bixin | Bixin. Group: Biochemicals. Alternative Names: 6-Methyl hydrogen (9Z)-6,6'-diapocarotene-6,6'-dioate. Grades: Highly Purified. CAS No. 6983-79-5. Pack Sizes: 1mg, 2mg, 5mg. US Biological Life Sciences. | Worldwide |
| Bixin min 90% | 1g Pack Size. Group: Aroma Chemicals, Research Organics & Inorganics, Stains & Indicators. Formula: C25H30O4. CAS No. 6983-79-5. Prepack ID 45995458-1g. Molecular Weight 394.5. See USA prepack pricing. |  |
| BIX NHE1 inhibitor | BIX NHE1 inhibitor is a potent and selective NHE1 inhibitor (IC50 = 31 nM). It attenuates ischemic damage in an ischemia reperfusion injury isolated rat heart model ex vivo, attenuates phenylephrine-induced cardiomyocyte hypertrophy in vitro. Synonyms: BI-9627; BI 9627; BI9627; 4-(1-Acetyl-4-piperidinyl)-N-(aminoiminomethyl)-3-(trifluoromethyl)benzamide hydrochloride. Grades: ≥98% by HPLC. CAS No. 1204329-34-9. Molecular formula: C16H19F3N4O2.HCl. Mole weight: 392.8. | |
| N-Debenzyl-N-methyl-O-demethyl-O-(3-dimethylaminopropyl)-BIX 01294 | N-Debenzyl-N-methyl-O-demethyl-O-(3-dimethylaminopropyl)-BIX 01294. Group: Biochemicals. Alternative Names: 7-[3- (Dimethylamino) propoxy]-2- (hexahydro-4-methyl-1H-1, 4-diazepin-1-yl) -6-methoxy-N- (1-methyl-4-piperidinyl) -4-quinazolinamine; UNC 0224. Grades: Highly Purified. CAS No. 1197196-48-7. Pack Sizes: 10mg. Molecular Formula: C26H43N7O2, Molecular Weight: 485.67. US Biological Life Sciences. | Worldwide |
| 1,1'-[1,3-Phenylenebis(methylene)]bis-1h-imidazole | 1,1'-[1,3-Phenylenebis(methylene)]bis-1h-imidazole. Group: Nitrogen-containing mof ligand-binary nitrogen-containing mof ligand. Alternative Names: 1,3-Bis((1H-Imidazol-1-Yl)Methyl)Benzene; 1-[[3-(imidazol-1-ylmethyl)phenyl]methyl]imidazole; m-bix; 1,3-bix. CAS No. 69506-92-9. Molecular formula: 238.29. Mole weight: C14H14N4. 98%. |  |
| 3-Methoxyphenylboronic acid MIDA ester | 3-Methoxyphenylboronic acid MIDA ester. Group: Salt. CAS No. 1104636-71-6. Product ID: 2-(3-methoxyphenyl)-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione. Molecular formula: 263.06g/mol. Mole weight: C12H14BNO5. B1 (OC (=O)CN (CC (=O)O1)C)C2=CC (=CC=C2)OC. InChI=1S/C12H14BNO5/c1-14-7-11 (15)18-13 (19-12 (16)8-14)9-4-3-5-10 (6-9)17-2/h3-6H, 7-8H2, 1-2H3. BIXVKIPQNJRPKQ-UHFFFAOYSA-N. | |
| Annatto Extract | Annatto Extract. Applications: Permitted natural color for use in food , cosmetics and pharmaceutical industries. Group: Others. Synonyms: Annatto Extract; 542-40-5; Bixa orellana L. CAS No. 542-40-5. Purity: 30%-70% Norbixin By HPLC. Appearance: Orange fine powder. Storage: 2 years under well storage situation and stored away from direct sun light. Source: Seed. Species: Bixa orellana L. Annatto Extract; 542-40-5; Bixa orellana L.; plant extract. Pack: 20KG-25KG/Drum with double plastic bag of foodstuff inside. Cat No: EXTW-113. |  |
| (±)-Bay K 8644 (1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl) phenyl]-3-pyridinecarboxylic Acid, Methyl Ester) | A L-type Ca2+-channel activator (EC50 = 17.3nM). In combination with BIX01294, enables reprogramming of Oct4/Klf4-transduced mouse embryonic fibroblasts. Group: Biochemicals. Alternative Names: (1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl) phenyl]-3-pyridinecarboxylic Acid, Methyl Ester). Grades: Highly Purified. CAS No. 71145-03-4. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| HMTase Inhibitor IV, UNC0638 (2-Cyclohexyl-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine) | A cell-permeable quinazolinamine compound that acts as a potent and reversible inhibitor of G9a and GLP HMTases (histone methyltransferases) (IC50=<15 and 19nM for G9a and GLP, respectively) and displays ~15-fold greater selectivity over DNMT1 and minimally blocks the activities of JMJD2E (IC50=4.66uM) and SETD7, SETD8, PRMT3 and SUV39H2 (IC50>10uM). Shown to lower H3K9Me2 levels in MDA-MB231 cells (IC50=81nM; EC50=11.2uM for cell toxicity) and 6-fold more potent than the HMTase Inhibitor, BIX-01294. Also, affects the activities of adrenergic a1A, adrenergic a and muscarinicM2 by 90%, 69% and 64% and a panel of 26-receptors and ion-channels by <30% at 1uM. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2mg. US Biological Life Sciences. | Worldwide |
| HMTase Inhibitor VI, BRD4770 (Methyl-2-benzamido-1-(3-phenylpropyl)-1H-benzo[d]imidazole-5-carboxylate) | A cell-permeable analog of the amino-benzimidazolo BIX-01338 and the methylester prodrug of BRD9539 that acts as an SAM-competitive inhibitor against PRC2 and G9a (IC50<6.3uM) histone methyltransferase activities, displaying little effect toward 10 other HMTases, 9 HDACs, and 100 cellular kinases. Selectively reduces H3K9me2 and H3K9me3 (EC50=5uM) histone methylation levels in pancreatic cancer cells (PANC-1) with much less or little effect toward H3K36me3, H3K4me3, H3K27me3, or H3K6me3 levels. Inhibits both anchorage-dependent and -independent PANC-1 proliferation via ATM activation and G2/M cell-cycle arrest, but not apoptosis induction (no caspase3/7 activation; 10uM, 72h). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| iPSC Induction Enhancer II, OAC1 N-(1H-Pyrrolo[2,3-c]pyridin-5-yl)benzamide, Induced Pluripotent Stem Cells Induction Enhancer II, Oct4-Activating Compound 1) | A cell-permeable pyrrolopyridinyl-benzamide compound that is reported to enhance the efficiency of 4F/4TF-induced iPSC generation from MEFs cultured in either feeder cell-containing ESC media or in feeder-/serum-free iSF1 media (1uM OAC1 treatment starts 48h after viral transduction). OCA1 is shown to increase cellular Oct4, Nanog, Sox2, and Tet1 mRNA levels via a yet unidentified mechanism, although OAC1 is reported not affect Oct4 promoter methylation, cellular Wnt signaling, or p53 and p21 mRNA levels. Six other iPSC reprogramming improving reagents, AM580, AzaC, BIX-01294, Tranylcypromine, VPA, and Vitamin C, in comparison, do not exhibit Oct4 and Nanog promoters enhancing activity, while BIO is demonstrated to be 3.8- and 6-fold less potent than OAC1, respectively, in inducing Oct4 and Nanog transcription. Group: Biochemicals. Grades: Highly Purified. CAS No. 300586-90-7. Pack Sizes: 25mg. Molecular Formula: C??H??N?O, Molecular Weight: 237.3. US Biological Life Sciences. | Worldwide |
| Manganese Iron Oxide Nanoparticle Dispersion | Manganese Iron Oxide Nanoparticle Dispersion. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Manganese Ferrite, Bixbyite Manganese Diiron Oxide, Iron manganese oxide, Iron manganese spinel, Manganese Iron Oxide nanopowder suspension, aqueous Manganese Iron Oxide nanoparticle solution, Manganese Iron Oxide nanofluid. Product Category: Nanoparticle Dispersions. Appearance: Liquid. CAS No. 12063-10-4. Molecular formula: Fe2MnO4. Mole weight: 230.63. Density: Varies by solvent. Product ID: ACM12063104-2. Alfa Chemistry ISO 9001:2015 Certified. |  |
| MEK Inhibitor | Selective dual MEK5 kinase inhibitor, with IC50 values of 4.3, 810, 1800, and >6300 nM for MEK5, ERK5, TGFbR1 and other closely related kinases respectively. Synonyms: MEK inhibitor; BIX 02188; BIX02188; BIX-02188; 1H-Indole-6-carboxamide, 3-[[[3-[ (dimethylamino) methyl]phenyl]amino]phenylmethylene]-2, 3-dihydro-N-methyl-2-oxo-, (3Z)-. Grades: >98%. CAS No. 334951-92-7. Molecular formula: C26H26N4O2. Mole weight: 426.51. | |
| RG 108 (N-Phthalyl-L-tryptophan) | A DNA methyltransferase (DNMT) inhibitor. RG108 causes demethylation and reactivation of tumor suppressor genes, but it does not affect the methylation of centromeric satellite sequences. In combination with BIX 01294, RG 108 enhances reprogramming. Group: Biochemicals. Grades: Highly Purified. CAS No. 48208-26-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| S(-)-BAY K 8644 | S(-)-BAY K 8644 is an activator of voltage-sensitive L-type calcium channels with positive inotropic, vasoconstrictive and behavioral effects in vivo. It is the enantiomer of (±)-Bay K 8644. It increased whole-cell Ca2+ currents in A7r5 smooth muscle cells but effectively blocked further stimulatio. It enhanced transcoronary exchange more markedly than (+/-)-Bay W 5035 or (+/-)-Bay T 5006, reflecting the differences in coronary constrictor activity. It demonstrates vasoconstrictive and positive inotropic effects in vivo as well as behavioral effects, including deficits to motor function. It can enable reprogramming of mouse embryonic fibroblasts after transduction with Oct4/Klf when combined with BIX01294. Uses: S(-)-bay k 8644 has positive inotropic, vasoconstrictive and behavioral effects. Synonyms: Methyl (4S)-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate;Bay-K-8644 (S)-(-)-;(S)-(-)-Bay-K-8644;(4S)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-(2-trifluoromethyl)phenyl)-3-pyridinecarboxylicacidmethylester;S-(-)-1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester;[4S,(-)]-1,4-Dihydro-2,6-dimethyl-5-nitro-4-(2-trifluoromethylphenyl)pyridine-3-carboxylic acid methyl ester. Grades: >99 %. CAS No. 98625-26-4. Molecular formula: C16H15F3N2O4. Mole weight: 356.30. | |
| Zirconium acrylate | Zirconium acrylate. Group: other materials. Alternative Names: Zirconium acrylate; zirconium tetraacrylate; 60653-57-8; tetrakis(acryloyloxy)zirconium; C-54320. CAS No. 60653-57-8. Product ID: prop-2-enoic acid; zirconium. Molecular formula: 379.476g/mol. Mole weight: C12H16O8Zr. C=CC(=O)O. C=CC(=O)O. C=CC(=O)O. C=CC(=O)O. [Zr]. InChI=1S/4C3H4O2.Zr/c4*1-2-3(4)5; /h4*2H, 1H2, (H, 4, 5);. BIXADNIHYBZLKU-UHFFFAOYSA-N. | |
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