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| Product | Description | |
|---|---|---|
| BML-278 | BML-278 is a selective Sirt1 activator (EC150 = 1μM) structurally based on a dihydropyridine scaffold. It has much weaker effects on Sirt2 and Sirt3. BML-278 is active in whole cells and arrests cell cycle at G1/S phase in U937 cells. It has much weaker effects on Sirt2 and Sirt3. BML-278 is active in whole cells and arrests cell cycle at G1/S phase in U937 cells. Synonyms: BML 278; BML278. Grades: ≥95%. CAS No. 120533-76-8. Molecular formula: C24H25NO4. Mole weight: 391.5. |  |
| BML-278 | BML-278 is a SIRT1 activator ( EC 150 : 1 μM). BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in both the paternal and maternal pronucleus. BML-278 improves early embryonic development. BML-278 arrests the cell cycle at the G1/S phase, and reduces senescence in primary human mesenchymal cells. BML-278 reduces tubulin acetylation in U937 cells. BML-278 also increases mitochondrial density in murine C2C12 myoblasts [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 120533-76-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-W025074. |  |
| BML-278, SIRT1 Inhibitor (N-Benzyl-3,5-dicarbethoxy-4-phenyl-1,4-dihydropyridine) | A structurally novel activator of SIRT1 (EC150=1uM). Displays selectivity over SIRT2 and 3 (EC150=25 and 50uM respectively). Cell permeable. Group: Biochemicals. Alternative Names: N-Benzyl-3,5-dicarbethoxy-4-phenyl-1,4-dihydropyridine. Grades: Highly Purified. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. |  Worldwide |
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