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| Product | Description | |
|---|---|---|
| BMS 299897 | BMS 299897 is a known γ-secretase inhibitor that effectively reduces amyloid β-peptide (A β) in transgenic mice and guinea pigs. Studies have shown the possibility of using BMS 299897 in the treatments for Alzheimers patients. Group: Biochemicals. Alternative Names: 2-[ (1R) -1-[[ (4-Chlorophenyl) sulfonyl] (2, 5-difluorophenyl) amino]ethyl]-5-fluorobenzenebutanoic Acid. Grades: Highly Purified. CAS No. 290315-45-6. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| BMS 299897 | BMS 299897, under the IUPAC name 4-[2-[(1R)-1-(N-(4-chlorophenyl)sulfonyl-2,5-difluoroanilino)ethyl]-5-fluorophenyl]butanoic acid, synthesized by the radiosynthesis group at Bristol-Myers Squibb, is a β-secretase inhibitor that has the potential for treatment of Alzheimer's diseases (IC50 = 12 nM; gamma-secretase express: EC50 = 7 nM (CHO cells)). BMS 299897 blocks the formation of Aβ40 (IC50 = 7.9 nM) and Aβ42 (IC50 = 7.9 nM) in the brain, and reduces Aβ in the brain, plasma and cerebrospinal fluid in vivo. Synonyms: 4-[2-[(1R)-1-(N-(4-chlorophenyl)sulfonyl-2,5-difluoroanilino)ethyl]-5-fluorophenyl]butanoic acid; 4-(2-((1R)-1-(((4-chlorophenyl)sulfonyl)-2,5-difluoroanilino)ethyl)-5-fluorophenyl)butanoic acid; BMS299897; BMS 299897; BMS-299897; 290315-45-6; 2-[(1R)-1-[[(4-Chlorophenyl)sulfonyl](2,5-difluorophenyl)amino]ethyl]-5-fluoro-benzenebutanoic acid; C24H21ClF3NO4S; CHEMBL247471; SCHEMBL6394108; DTXSID50460039; 3496AH; ZINC28883606; AKOS024457319; CCG-222540; CS-1339; NCGC00346875-01; HY-50883; KB-75603; DB-017854; W-5550; BRD-K02950022-001-01-1; 2-[(1R)-1-[[(4-chlorophenyl)sulfonyl](2,5-difluorophenyl)amino]ethyl]-5-fluoroBenzenebutanoic acid; BMS 299897|2-[(1R)-1-[[(4-Chlorophenyl)sulfonyl](2,5-difluorophenyl)amino]ethyl-5-fluorobenzenebutanoic acid. CAS No. 290315-45-6. Molecular formula: C24H21ClF3NO4S. Mole weight: 511.94. |  |
| BMS 299897, gamma-Secretase Inhibitor XXIV (4-(2-((1R)-1-(((4-Chlorophenyl)sulfonyl)-2,5-difluoroanilino)ethyl)-5-fluorophenyl)butanoic Acid, BMS-299897, BMS 299897) | An orally bioavailable sulfonamide compound that acts as a potent, reversible and allosteric y-secretase activity inhibitor with ~15-fold greater selectivity over Notch-1 proteolysis processing (IC50=7.1 and 105.9nM in HEK293-wtAPP) and preferentially inhibits PS1 (presenillin 1)-comprised y-secretase (EC50=8, 108, 286 and 29nM for PS1, Triple PS1-L172M,T281P, L282I, PS2 and Triple PS2-M178L, P287T, I288L), respectively). Shown to reduce the levels of Ab38, Ab40 and Ab42 in Tg2576 mice, Ab40 brain and plasma in APP-YAC mice (ED50=30 and 16mg/kg, p.o.) and Abtotal brain, CSF and plasma in guinea pigs (ED50=30mg/kg, i.p.). Group: Biochemicals. Grades: Highly Purified. CAS No. 290315-45-6. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
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