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An impurity of Vardenafil. Vardenafil is a PDE5 inhibitor used for the treatment of erectile dysfunction. Synonyms: Vardenafil Impurity 3; 2-(2-Ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5,7-dimethylimidazo[5,1-f][1,2,4]triazin-4(3H)-one. Molecular formula: C21H28N6O4S. Mole weight: 460.56.
Abemaciclib
Abemaciclib is an orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. It is used for the treatment of advanced or metastatic breast cancers. Synonyms: LY-2835219; LY 2835219; LY2835219; Verzenio; N-[5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl]-5-fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-amine. Grades: ≥98%. CAS No. 1231929-97-7. Molecular formula: C27H32F2N8. Mole weight: 506.61.
Abemaciclib-[d5]
Labelled Abemaciclib. Abemaciclib is an orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. It is used for the treatment of advanced or metastatic breast cancers. Synonyms: N-[5-[(4-Ethyl-1-piperazinyl)methyl]-2-pyridinyl]-5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-2-pyrimidinamine-d5; N-(5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine-d5. Grades: > 98%. CAS No. 1809251-51-1. Molecular formula: C27H27D5F2N8. Mole weight: 511.62.
Abemaciclib-[d7]
Labelled Abemaciclib. Abemaciclib is an orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. It is used for the treatment of advanced or metastatic breast cancers. Synonyms: N-(5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine-d7. Grades: > 98%. Molecular formula: C27H25D7F2N8. Mole weight: 513.64.
abemaciclib mesylate
Abemaciclib mesylate is a CDK inhibitor with selectivity for CDK4 and CDK6. It was approved for the treatment of advanced or metastatic breast cancers. Uses: The treatment of advanced or metastatic breast cancers. Synonyms: Verzenio; LY2835219; LY 2835219; LY-2835219; UNII-KKT462Q807; Abemaciclib methanesulfonate; N-(5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine methanesulfonate. CAS No. 1231930-82-7. Molecular formula: C28H36F2N8O3S. Mole weight: 602.706.
AEE-788
AEE-788 is an orally bioavailable multiple-receptor tyrosine kinase inhibitor. AEE788 inhibits phosphorylation of the tyrosine kinases of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and vascular endothelial growth factor receptor 2 (VEGF2), resulting in receptor inhibition, the inhibition of cellular proliferation, and induction of tumor cell and tumor-associated endothelial cell apoptosis. Synonyms: AEE 788; AEE788; 6-[4-[(4-ethylpiperazin-1-yl)methyl]phenyl]-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine. Grades: >98%. CAS No. 497839-62-0. Molecular formula: C27H32N6. Mole weight: 440.595.
BGJ-398
BGJ398, also known as NVP-BGJ398, is a pan FGFR kinase inhibitor, and is an orally bioavailable pan inhibitor of human fibroblast growth factor receptors (FGFRs) with potential antiangiogenic and antineoplastic activities. BGJ398 selectively binds to and inhibits the activities of FGFRs, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death. Synonyms: 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-((4-(4-ethylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)-1-methylurea; NVPBGJ398; NVPBGJ 398; NVPBGJ-398; BGJ398; BGJ-398; BG J398; Infigratinib. Grades: 0.98. CAS No. 872511-34-7. Molecular formula: C26H31Cl2N7O3. Mole weight: 560.48.
Blonanserin
A 5-HT2 serotonin receptor and D2 dopamine receptor antagonist, used as an antipsychotic. Synonyms: 2-(4-ethylpiperazin-1-yl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine. Grades: 0.99. CAS No. 132810-10-7. Molecular formula: C23H30FN3. Mole weight: 367.512.
Gisadenafil
Gisadenafi is a potent PDE5 inhibitor (IC50 = 1.23 nM). Uses: A potent pde5 inhibitor. Synonyms: UK-369003; UK-369,003; 1-{6-ethoxy-5-[3-ethyl-6,7-dihydro-2-(2-methoxyethyl)-7-oxo-2H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-pyridylsulfonyl}-4-ethylpiperazine. Grades: ≥98%. CAS No. 334826-98-1. Molecular formula: C23H33N7O5S. Mole weight: 519.62.
JNJ-39327041
JNJ-39327041 is a bio-active chemical compound. Synonyms: JNJ-39327041; JNJ 39327041; JNJ39327041. N-[(4R)-4-(3,4-dimethoxyphenyl)-4-[7-(4-ethylpiperazin-1-yl)-3-oxo-1H-isoindol-2-yl]butyl]-1,2-dimethylimidazole-4-sulfonamide;JNJ39327041;1H-Imidazole-4-sulfonamide, N-((4R)-4-(3,4-dimethoxyphenyl)-4-(4-(4-ethyl-1-piperazinyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl)butyl)-1,2-dimethyl-. Grades: 95%. CAS No. 1093069-32-9. Molecular formula: C31H42N6O5S. Mole weight: 610.77.
KU-0060648
KU-0060648 is a dual inhibitor of DNA-PK (IC50=8.6 nM) and PI3Kα (IC50=4 nM), PI3Kβ (IC50=0.5 nM), PI3Kδ (IC50=0.1 nM) less inhibition of PI3Kγ with IC50 of 0.59 μM. Synonyms: KU0060648; KU 0060648; N-[4-(2-Morpholino-4-oxo-4H-1-benzopyran-8-yl)dibenzothiophene-1-yl]-4-ethylpiperazine-1-acetamide. Grades: >98%. CAS No. 881375-00-4. Molecular formula: C33H34N4O4S. Mole weight: 582.71.
ML311
ML311, also known as EU-5346, is a potent and selective inhibitor of the Protein-Protein Interaction of Mcl-1 and Bim. EU-5346 inhibits proliferation of Her2-positive BC cells in a dose-dependent manner. ML311 is a useful tool for studying lymphoid tumorigenesis and to demonstrate the potential for using this strategy in therapies intended to bypass apoptosis resistance pathways that are activated in drug-resistant tumors. Synonyms: 7-[ (4-Ethylpiperazin-1-yl) -[4- (trifluoromethyl) phenyl]methyl]quinolin-8-ol; ML311; ML-311; ML 311; EU-5346; EU 5346; EU5346. CAS No. 315698-17-0. Molecular formula: C23H24F3N3O. Mole weight: 415.46.
Palbociclib N-Ethyl
An impurity of Palbociclib which is a drug for the treatment of ER-positive and HER2-negative breast cancer. Synonyms: 6-acetyl-8-cyclopentyl-2-((5-(4-ethylpiperazin-1-yl)pyridin-2-yl)amino)-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one; Palbociclib impurity 33. Grades: ≥95%. CAS No. 1974279-40-7. Molecular formula: C26H33N7O2. Mole weight: 475.59.
Quetiapine Impurity P (11-(4-Ethylpiperazin-1-yl)dibenzo[b,f][1,4]thiazepine fumarate))
An impurity of Quetiapine. Quetiapine is an atypical antipsychotic used for the treatment of schizophrenia, bipolar disorder, and major depressive disorder. Synonyms: Quetiapine EP Impurity P; N-Ethyl quetiapine; RWH9KS2BXZ; DES(2-hydroxyethoxy)quetiapine; 6-(4-ethylpiperazin-1-yl)benzo[b][1,4]benzothiazepine; 11-(4-Ethyl-1-piperazinyl)dibenzo(b, f)(1, 4)thiazepine; 11-(4-Ethylpiperazin-1-yl)dibenzo(b,f)(1,4)thiazepine; Dibenzo(b,f)(1,4)thiazepine, 11-(4-ethyl-1-piperazinyl)-; Quetiapine IMpurity P (11-(4-Ethylpiperazin-1-yl)dibenzo[b,f][1,4]thiazepine fuMarate)); 11-(4-Ethylpiperazin-1-yl)dibenzo[b,f][1,4]thiazepine; Dibenzo[b,f][1,4]thiazepine, 11-(4-ethyl-1-piperazinyl)-; UNII-RWH9KS2BXZ; N-Ethyl quetiapine [USP]; DTXSID101212479; Quetiapine fumarate impurity P [EP]; N-ETHYL QUETIAPINE [USP IMPURITY]; QUETIAPINE FUMARATE IMPURITY P [EP IMPURITY]; Dibenzo[b,f][1,4]thiazepine,11-(4-ethyl-1-piperazinyl)-; 11-(4-Ethyl-1-piperazinyl)-dibenzo[b,f][1,4]thiazepine Dihydrochloride. Grades: > 95%. Molecular formula: C19H21N3S. C4H4O4. Mole weight: 439.53.
SCH 546738
SCH 546738 is a novel, potent and non-competitive small molecule CXCR3 antagonist with Ki of 0.4 nM. Synonyms: SCH546738; SCH 546738; SCH-546738; 3-amino-6-chloro-5-[(3S)-4-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-3-ethylpiperazin-1-yl]pyrazine-2-carboxamide. CAS No. 906805-42-3. Molecular formula: C23H31Cl2N7O. Mole weight: 492.44.
Vardenafil dihydrochloride
Vardenafil, also called as Levitra and Nuviva, is a phosphodiesterase inhibitor that is selective for PDE5 and PDE1 (IC50 = 0.7 and 180 nM, respectively). Uses: A selective phsphodiesterase type 5 (pde5) inhibitor. Synonyms: BAY 38-9456; BAY-38-9456; BAY38-9456; Vardenafil HCl; 2-[2-ethoxy-5-(4-ethylpiperazin-1-yl)sulfonylphenyl]-5-methyl-7-propyl-1H-imidazo[5,1-f][1,2,4]triazin-4-one;dihydrochloride; 1-(((3-(3,4-dihydro-5-methyl)-4-oxo-7-propylimidazo(5,1-f)-as-triazin-2-yl)-4-ethoxyphenyl)sulfonyl)-4-ethylpiperazine; Anhydrous, Vardenafil Hydrochloride; Dihydrochloride, Vardenafil; Hydrochloride Anhydrous, Vardenafil; Levitra; vardenafil. Grades: >98%. CAS No. 224789-15-5. Molecular formula: C23H34Cl2N6O4S. Mole weight: 561.523.
Vardenafil N-Oxide
An impurity of Vardenafil. Vardenafil is a PDE5 inhibitor used for the treatment of erectile dysfunction. Synonyms: 4-((4-ethoxy-3-(5-methyl-4-oxo-7-propyl-1,4-dihydroimidazo[5,1-f][1,2,4]triazin-2-yl)phenyl)sulfonyl)-1-ethylpiperazine 1-oxide. Molecular formula: C23H32N6O5S. Mole weight: 504.61.
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