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| Product | Description | |
|---|---|---|
| Borrelidin | Borrelidin. Group: Biochemicals. Grades: Purified. CAS No. 7184-60-3. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| Borrelidin | Borrelidin is a macrolide antibiotic produced by Streptomyces rochei and Streptomy- ces sp.C 2989. It has anti-gram-positive bacteria, Borrelia, Cryptococcus neoformans, Tetrahymena gili and Trichomonas vaginalis. It has antiviral and antitumor activity. It can inhibit threonyl tRNA synthetase and protein synthesis. Synonyms: (-)-borrelidin. Grades: >98%. CAS No. 7184-60-3. Molecular formula: C28H43NO6. Mole weight: 489.64. |  |
| Borrelidin | from Streptomyces parvulus, ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| Borrelidin (Treponemycin, Antibiotic U 78548, Antibiotic C2989) | Borrelidin is an unusual nitrile containing metabolite isolated from Streptomyces. Originally discovered as active against against Borrelia species, borrelidin has since found a role as a selective inhibitor of bacterial and eukaryal threonyl-tRNA synthetase. More recent research has found that borrelidin is a very potent angiogenesis inhibitor and induces apoptosis of the capillary tube-forming cells. Borrelidin is an important lead for antimalarial discovery displaying activity against drug-resistant Plasmodia. Group: Biochemicals. Alternative Names: Treponemycin, Antibiotic U 78548, Antibiotic C2989. Grades: Highly Purified. CAS No. 7184-60-3. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| Borrelidin (Treponemycin, U 78548, C2989) | Macrolide antibiotic. Bacterial and eukaryal threonyl-tRNA synthetase (THrRS) inhibitor. Antiangiogenic (IC50=0.8nM). Induces the collapse of formed capillary tubes in a dose-dependent fashion. In HUVECs, the capillary tube collapsing activity is mediated by the activation of caspases-3 and -8 and induction of apoptosis. Blocks the formation of spontaneous lung metastases of B16-BL6 melanoma cells. Cyclin-dependent kinase (CDK) inhibitor. Antiviral. Antimalarial. Group: Biochemicals. Grades: Highly Purified. CAS No. 7184-60-3. Pack Sizes: 500ug, 1mg, 5mg. US Biological Life Sciences. | Worldwide |
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