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| Product | Description | |
|---|---|---|
| Brequinar | Brequinar is a synthetic quinolinecarboxylic acid analogue with antineoplastic properties. Brequinar inhibits the enzyme dihydroorotate dehydrogenase, thereby blocking de novo pyrimidine biosynthesis. This agent may also enhance the in vivo antitumor effect of antineoplastic agents such as 5-FU. Check for active clinical trials or closed clinical trials using this agent. Synonyms: DUP785; NSC 368390; 6-Fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid; 6-fluoro-2-(2'-fluorobiphenyl-4-yl)-3-methylquinoline-4-carboxylic acid; 4-Quinolinecarboxylic acid, 6-fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methyl-; Biphenquinate. Grades: ≥98%. CAS No. 96187-53-0. Molecular formula: C23H15F2NO2. Mole weight: 375.37. |  |
| Brequinar sodium | Brequinar sodium is a potent and selective dihydroorotate dehydrogenase (DHODH) inhibitor (IC50 = ~20 nM), which causes the blockade of de novo pyrimidine nucleotide biosynthesis. Uses: Antineoplastic agents. Synonyms: Dup785; Dup 785; Dup-785; Brequinar Sodium. 6-Fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methyl-4-quinolinecarboxylic acid sodium; Dup 785. Grades: ≥99% by HPLC. CAS No. 96201-88-6. Molecular formula: C23H14F2NO2Na. Mole weight: 397.35. | |
| Brequinar sodium salt hydrate | ?97% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| Dihydroorotate Dehydrogenase Inhibitor, Brequinar (6-fluoro-2-(2-fluoro-1,1-biphenyl-4-yl)-3-methyl-4-quinoline-carboxylic Acid Sodium Salt, NSC 368390, DuP 785) | A quinolinecarboxylic acid derivative with immunosuppressive and anti-neoplastic properties. Inhibits pyrimidine synthesis by blocking the activity of mammalian mitochondrial dihydroorotate dehydrogenase (DHODH; IC50 = 12nM). Does not affect DHODH in non-mammalian species. Also reported to inhibit glycosylation of adhesion molecules. Potentiates the sensitivity of U1690 small cell lung cancer cells to TRAIL-induced apoptosis and synergistically enhances the anti-tumor effects of doxorubicin ( ~100uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 96201-88-6. Pack Sizes: 10mg. Molecular Formula: C??H??F?NNaO?, Primary Target: DHODH. US Biological Life Sciences. |  Worldwide |
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