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| Product | Description | |
|---|---|---|
| Briciclib | Briciclib is a small molecule that suppresses cyclin D1 accumulation in cancer cells. It is a benzyl styryl sulfone analog, and a disodium phosphate ester prodrug of ON 013100, with potential antineoplastic activity. It may exhibit synergistic antitumor activity in combination with other chemotherapeutic agents. It inhibits the proliferation of MCL, gastric, breast and esophageal cancer cell lines at nanomolar concentrations (GI50 = 9.8 - 12.2 nM) in vitro. It binds to eIF4E, blocking cap-dependent translation of cyclin D1 and other cancer proteins and leads to tumor cell death in vitro. It is active in nonclinical tumor models when combined with several chemotherapeutics. Uses: Briciclib may exhibit synergistic antitumor activity in combination with other chemotherapeutic agents. it is active in nonclinical tumor models when combined with several chemotherapeutics. Synonyms: Phenol, 2-Methoxy-5-[[[ (1E) -2- (2, 4, 6-triMethoxyphenyl) ethenyl]sulfonyl]Methyl]-, 1-(dihydrogen phosphate);ON-014185;(E)-5-[[(2,4,6-Trimethoxystyryl)sulfonyl]methyl]-2-methoxyphenyl dihydrogen phosphate; [2-methoxy-5-[[ (E) -2- (2, 4, 6-trimethoxyphenyl) ethenyl]sulfonylmethyl]phenyl] dihydrogen phosphate. Grades: >98 %. CAS No. 865783-99-9. Molecular formula: C19H23O10PS. Mole weight: 474.42. |  |
| Briciclib sodium | Briciclib, also known as ON 013105 or ON 014185, is a benzyl styryl sulfone analog, and a disodium phosphate ester prodrug of ON 013100, with potential antineoplastic activity. Upon hydrolysis, cyclin D modulator ON 013105 is converted to ON 013100, which blocks cyclin D mRNA translation and decreases protein expression of cyclin D. This may induce cell cycle arrest and apoptosis in cancer cells overexpressing cyclin D and eventually decrease tumor cell proliferation. This agent may exhibit synergistic antitumor activity in combination with other chemotherapeutic agents. Cyclin D, a member of the cyclin family of cell cycle regulators, plays a key role in cell cycle division and is often overexpressed in a variety of hematologic and solid tumors and is correlated with poor prognosis. Synonyms: ON-013105; ON013105; ON 013105; ON 014185; ON014185; ON-014185. Grades: >98%. CAS No. 865784-01-6. Molecular formula: C19H21Na2O10PS. Mole weight: 518.38. | |
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