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| Product | Description | |
|---|---|---|
| Brigatinib | Brigatinib, also known as AP-26113, is an orally active, potent and selective dual ALK/EGFR inhibitor. AP26113 is an orally bioavailable inhibitor of anaplastic lymphoma kinase (ALK; IC50 < 100 nM in Ba/F3 cells). AP26113 binds to and inhibits ALK kinase and ALK fusion proteins as well as EGFR and mutant forms. It blocks ALK activity and reduces growth in neuroblastoma cells, mouse xenograft, and Drosophila model systems harboring constitutively active ALK variants. Synonyms: AP26113. Grades: ≥98%. CAS No. 1197953-54-0. Molecular formula: C29H39ClN7O2P. Mole weight: 584.10. |  |
| Brigatinib | Brigatinib (AP-26113) is a highly potent, selective and orally active ALK inhibitor, with an IC 50 of 0.6 nM. Brigatinib can be used for research of NSCLC [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AP-26113. CAS No. 1197953-54-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12857. |  |
| Brigatinib C | Brigatinib C is a linker, as a part of PROTAC Linker to target HJM-561 (HY-156698). Uses: Scientific research. Group: Signaling pathways. CAS No. 1197958-75-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-150910. | |
| AP-26113 | AP26113 is an orally available inhibitor of receptor tyrosine kinases anaplastic lymphoma kinase (ALK) and the epidermal growth factor receptor (EGFR) with potential antineoplastic activity. AP26113 binds to and inhibits ALK kinase and ALK fusion proteins as well as EGFR and mutant forms. AP26113 appears to overcome mutation-based resistance. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. Synonyms: AP-26113; AP 26113; AP26113; (2-((5-chloro-2-((4-(4-(dimethylamino)piperidin-1-yl)-2-methoxyphenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide; AP26113-analog; AP-26113-analog; AP 26113-analog, Brigatinib-analog. Grades: 0.98. CAS No. 1197958-12-5. Molecular formula: C26H34ClN6O2P. Mole weight: 529.01. | |
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