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| Product | Description | |
|---|---|---|
| Brilacidin | An investigational antibiotic effective against Gram-positive and Gram-negative bacteria, which is a non-peptide small molecule modeled after host defense peptides (HDPs). It is currently under clinical trials for the treatment of head and neck neoplasms as well as mucositis. Uses: Anti-infective agents. Synonyms: PMX30063; PMX-30063; PMX 30063. Grades: 98%. CAS No. 1224095-98-0. Molecular formula: C40H50F6N14O6. Mole weight: 936.90. |  |
| Brilacidin | Brilacidin (PMX 30063) is an anti-infective antimicrobial with MIC90s of 1 and 8 μg/mL for Gram-positive bacteria Streptococcus pneumonia and Streptococcus viridans , and MIC90 of 8 and 4 μg/mL for Gram-negative bacteria Haemophilus influenza and Pseudomonas aeruginosa. Brilacidin is a defensin mimetic antibiotic compound [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PMX 30063. CAS No. 1224095-98-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-19892. |  |
| Brilacidin HCl | Brilacidin, also known as PMX30063, is an arylamide foldamer designed to replicate the amphiphilic properties of antimicrobial peptides while solving the problems encountered by peptide-based antimicrobials. Brilacidin, a broad-spectrum antibiotic, has potent Gram positive activity and Gram negative coverage, and is highly effective in treating the 'superbug' methicillin-resistant Staphylococcus aureus (MRSA). Brilacidin has low cytotoxicity against mammalian cells selectively targeting bacteria, directly and rapidly disrupting their membranes, resulting in the bacteria's death. Due to this unique mechanism of action (mimicking the host's natural immune response, proven to be successful in fighting off infections over millions of years of evolution), bacterial antibiotic resistance is less likely to develop. Uses: Designed for use in research and industrial production. Additional or Alternative Names: PMX30063; PMX-30063; PMX 30063; Brilacidin; Brilacidin HCl; Brilacidin tetrahydrochloride. Product Category: Others. Appearance: Solid powder. CAS No. 1224095-99-1. Molecular formula: C40H54Cl4F6N14O6. Mole weight: 1082.75. Purity: >98%. IUPACName: N4,N6-bis(3-(5-guanidinopentanamido)-2-(((R)-pyrrolidin-3-yl)oxy)-5-(trifluoromethyl)phenyl)pyrimidine-4,6-dicarboxamide tetrahydrochloride. Canonical SMILES: O=C(C1=NC=NC(C(NC2=CC(C(F)(F)F)=CC(NC(CCCCNC(N)=N)=O)=C2O[C@H]3CNCC3)=O)=C1)NC4=CC(C(F)(F)F)=CC(NC(CCCCNC(N)=N)=O)=C4O[C@H] |  |
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