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Bromosporine ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. Alfa Chemistry Analytical Products 3
Bromosporine Bromosporine, a broad spectrum inhibitor for bromodomains which play a key role in many cellular processes, is a chemical probe for bromodomain functional assays so that it is very helpful in elucidating further biological roles of reader domains. IC50: B. Synonyms: Bromosporine; 1619994-69-2; ethyl (3-methyl-6-(4-methyl-3-(methylsulfonamido)phenyl)-[1,2,4]triazolo[4,3-b]pyridazin-8-yl)carbamate; CHEMBL3133807; Carbamic acid, N-[3-methyl-6-[4-methyl-3-[(methylsulfonyl)amino]phenyl]-1,2,4-triazolo[4,3-b]pyridazin-8-yl]-, ethyl ester; ethyl N-[6-(3-methanesulfonamido-4-methylphenyl)-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-yl]carbamate; ethyl N-[6-[3-(methanesulfonamido)-4-methylphenyl]-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-yl]carbamate; Bromosporine?; GTPL8234; SCHEMBL17359131; Bromosporine, >=98% (HPLC); GLXC-04090; HMS3653C21; BDBM50504160; MFCD26142669; NSC768126; s7233; AKOS024458332; CCG-268692; CS-3240; NSC-768126; NCGC00351471-11; AS-75091; BB170570; BP-25350; DA-61904; HY-15815; SW219727-1; C73098; A904240; BRD-K44665581-001-01-8; Q27075529; ethyl (3-methyl-6-{4-methyl-3-[(methylsulfonyl)amino]phenyl}[1,2,4]triazolo[4,3-b]pyridazin-8-yl)carbamate. CAS No. 1619994-69-2. Molecular formula: C17H20N6O4S. Mole weight: 404.44. BOC Sciences 6
Bromosporine Bromosporine is a potent BET inhibitor with an IC50 value of 2.1 ?M for PCAF. Bromosporine can arrest cell cycle and induce apoptosis in cancer cells. Bromosporine exhibits excellent antitumor activity in xenograft mice model when combined with 5-FU (HY-90006). Bromosporine can increase CDK9 T-loop phosphorylation in HIV-1 latency models, resulting the protection of reactivate HIV-1 replication from latency. Bromosporine can be used to research colorectal cancer, acute myeloid leukemia (AML) and AIDS[1][2][3][4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1619994-69-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15815. MedChemExpress MCE

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