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| Product | Description | |
|---|---|---|
| BTZO 1 | BTZO 1. Group: Biochemicals. Grades: Purified. CAS No. 99420-15-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| BTZO 1 | BTZO 1 is a macrophage migration inhibitory factor (MIF) binder (Kd = 68.6 nM). BTZO 1 activates antioxidant response element (ARE)-mediated gene expression and inhibits oxidative stress-induced cardiomyocyte apoptosis in vitro. Uses: Cardioprotective. Synonyms: BTZO1; BTZO 1; BTZO-1; 2-(2-Pyridinyl)-4H-1,3-benzothiazin-4-one. Grades: ≥99% by HPLC. CAS No. 99420-15-2. Molecular formula: C13H8N2OS. Mole weight: 240.28. |  |
| ARE Activator, BTZO-1 (Macrophage Migration Inhibitory Factor Antagonist II, 2-Pyridin-2-yl-4H-1,3-benzothiazin-4-one, MIF Antagonist II) | A cell-permeable benzothiazinone that is shown to interact with MIF homotrimer (=68.6nM and 157nM toward human and rat MIF, respectively, at pH 7.3) via the N-terminal proline in a pH-dependent manner, limiting its inhibitory capability against MIF tautomerase activity (13% inhibition at pH 6.0; [BTZO-1] = 30uM) due to reduced MIF binding at acidic pH. Shown to protect primary rat cardiomyocytes (330nM) from apoptotic death upon serum deprivation or DOX (200nM) treatment via activation of ARE- (antioxidant response element) mediated cytoprotective genes transcription in a MIF-dependent manner. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H?N?OS, Molecular Weight: 240.3. US Biological Life Sciences. | Worldwide |
| BTZO-1 | BTZO-1 binds to Macrophage migration inhibitory factor (MIF) with a K d value of 68.6 nM, and its binding requires the N-terminal Pro1. BTZO-1 can activate antioxidant response element ( ARE )-mediated gene expression and suppress oxidative stress-induced cardiomyocyte apoptosis in vitro [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 99420-15-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110084. |  |
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