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Afatinib impurity 40. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-4-((S)-4-chloro-3-hydroxybutoxy)butane-1,3-diol. Molecular Formula: C8H17ClO4. Mole Weight: 212.67. Catalog: APB02288.
Butylene Glycol
Butylene glycol occurs as a clear, colorless, viscous liquid with a sweet flavor and bitter aftertaste. Synonyms: Butane-1,3-diol; 1,3-butylene glycol; b-butylene glycol; 1,3-dihy- droxybutane; methyltrimethylene glycol. CAS No. 107-88-0. Product ID: PE0400. Molecular formula: C4H10O2. Mole weight: 90.14. Category: Preservatives; Humectants; Solvents. Product Keywords: Pharmaceutical Excipients; Other Materials; Humectants; Butylene Glycol; PE0400; 3XUS85K0RA; 107-88-0; 107-88-0. UNII: 3XUS85K0RA. Chemical Name: 1,3-Butanediol. Grade: Pharmceutical Excipients. Dosage Form: Transdermal patches;topical gel patches/medicated plasters. Stability and Storage Conditions: Butylene glycol is hygroscopic and should be stored in a well-closed container in a cool, dry, well-ventilated place. When heated to decomposition, butylene glycol emits acrid smoke and irritating fumes. Source and Preparation: Butylene glycol is prepared by catalytic hydrogenation of aldol using Raney nickel. Applications: Butylene glycol is used as a solvent and cosolvent for injectables.It is used in topical ointments, creams, and lotions,and it is also used as a vehicle in transdermal patches. Butylene glycol is a good solvent for many pharmaceuticals, especially estrogenic substances.In an oil-in-water emulsion, butylene glycol exerts its best antimicrobial effects at 8% concentration.Higher concentrations above 16.7% are required to inhibit fungal
NSC12
NSC12 is an extracellular trap for fibroblast growth factor 2 (FGF2). It binds FGF2 with Kd value of 51 μM and interferes with its interaction with FGFR1 without affecting the ability of FGF2 to bind heparin or heparin sulfate proteoglycans. It also binds several other FGF isoforms and prevents them from forming HSPG/FGF/FGFR ternary complexes. It inhibits FGF-dependent angiogenesis and tumor cell proliferation in vitro and reduces tumor growth in mice. It inhibited the proliferation of different FGF-dependent tumour cell lines, but had no inhibitory effect on FGF-independent tumour cells expressing a constitutively active FGFR1. It was shown to inhibit FGFR phosphorylation, angiogenesis and primary and metastatic tumour growth of FGF-dependent human and mouse cancer cells in vivo. It has significant implications in cancer therapy. Uses: Nsc12 has significant implications in cancer therapy. Synonyms: NSC-12; NSC 12; NSC12; NSC 172285; NSC-172285; NSC172285; 21- (Hydroxy (bistrifluoromethyl)methyl)pregnane-3, 20-diol; Pregn-5-ene-3, 20-diol, 21-(2-hydroxy-1,1,1,3,3,3-hexafluoro-2-propyl)-;LS-118618;4,4,4-Trifluoro-1-[(8S,9S,10R,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-3-(trifluoromethyl)butane-1,3-diol;NSC-12;NSC-172285;NSC172285;(R)-4,4,4-trifluoro-1-((3S,8S,9S,10R,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-3-(trifluoromethyl)butane-1,3-diol. Grades: >98 %. CAS No. 102586-30-1. Molecular formula: C24H34F6O3. Mole weight: 484.52.
(R)-(-)-1,3-Butanediol
(R) - (- ) - 1, 3- Butanediol is a chiral reagent used in the synthesis of pharmaceuticals including the preparation of (- ) - tarchonanthuslactone, a δ- lactone skeleton based compound with antiroliferative activity on cancer cell. Group: Biochemicals. Alternative Names: (3R)-1,3-Butanediol; (-)-1,3-Butanediol; (R)-(-)-1,3-Butanediol; (R)-1,3-Butanediol; L-Butane-1,3-diol. Grades: Highly Purified. CAS No. 6290-3-5. Pack Sizes: 5g, 10g, 25g. Molecular Formula: C?H??O?, Molecular Weight: 90.12. US Biological Life Sciences.
Worldwide
2-Ethyl-1,3-propanediol
2-Ethyl-1,3-propanediol is an intermediate in the synthesis of Peloruside A related compounds, which are antimitotic agents with Paclitaxel-like microtubule-stabilizing activity. Synonyms: 2-(hydroxymethyl)butanol; 2-ethyl-propan-1,3-diol; dimethylol propane; 2-(hydroxymethyl)butan-1-ol. Grades: 96%. CAS No. 2612-29-5. Molecular formula: C5H12O2. Mole weight: 104.15.
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