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| Product | Description | |
|---|---|---|
| C188-9 | C188-9 is a STAT3 inhibitor. HDM-induced airway inflammation, remodeling, and Th2/Th17-type cell accumulation involve STAT3 activation that can be prevented by C188-9 treatment. STAT3 inhibition with C188-9 resulted in attenuated skin fibrosis, myofibroblast accumulation, pro-fibrotic gene expression and collagen deposition in both mouse models of skin fibrosis. C188-9 decreased in vitro dermal fibroblast production of fibrotic genes induced by IL-6 trans-signalling and TGF-β. Finally, TGF-β induced phosphotyrosylation of STAT3 in a SMAD3-dependent manner. Uses: Designed for use in research and industrial production. Additional or Alternative Names: C188-9; C 188-9; C-188-9; C-1889; C1889; C 1889; C-1889; F0808-0084. Product Category: Inhibitors. Appearance: Pinky beige solid powder. CAS No. 432001-19-9. Molecular formula: C27H21NO5S. Mole weight: 471.52. Purity: >98%. IUPACName: N-(1',2-dihydroxy-[1,2'-binaphthalen]-4'-yl)-4-methoxybenzenesulfonamide. Canonical SMILES: O=S(C1=CC=C(OC)C=C1)(NC2=C3C=CC=CC3=C(O)C(C4=C5C=CC=CC5=CC=C4O)=C2)=O. Product ID: ACM432001199. Alfa Chemistry ISO 9001:2015 Certified. Categories: C/1889 O1 (Davidson). |  |
| C188-9 | C188-9 (TTI-101) is a STAT3 inhibitor, with a K d of 4.7 nM. C188-9 inhibits G-CSF-induced STAT3 activation and STAT3-dependent gene expression. C188-9 induces apoptosis in AML cell lines and primary samples and inhibits colony formation by primary AML blasts [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TTI-101. CAS No. 432001-19-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112288. |  |
| STAT3 Inhibitor XIII, C188-9 (N- (1, 2-Dihydroxy-1, 2-binaphthalen-4-yl) -4-methoxy Benzene sulfonamide, F1113-0789) | A cell-permeable binaphthol-sulfonamide compound that competitively disrupts Stat3 SH2 domain-pY peptide interaction and acts as a reversible inhibitor of Stat3 activation and Stat3-dependent gene transcription. Shown to block G-CSF stimulated pStat3 (IC50=4.1, 4.5 and 8.3uM in KG-1, Kasumi-1 and NB-4 cells, respectively), with no effect on ligand-induced pStat1 and selectively induce apoptosis of Stat3-dependent AML cells ((EC50 of 6-8uM) and growth arrest. Moderately affects Tie2 kinase activity (<50%) with minimal effect on JAK1, JAK2, Src family kinases and pERK1/2 and pAKT at 10uM. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
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