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| Product | Description | |
|---|---|---|
| CAL-130 Hydrochloride | CAL-130 is a PI3Kδ and PI3Kγ inhibitor with IC 50 s of 1.3 and 6.1 nM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1431697-78-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-16122B. |  |
| CAL-130 Hydrochloride | In the absence of PTEN phosphatase tumor suppressor function, PI3Kγ or PI3Kδ alone can support leukemogenesis, whereas inactivation of both isoforms suppressed tumor formation. The reliance of PTEN null T-ALL on the combined activities of PI3Kγ/δ was further demonstrated by the ability of a dual inhibitor to reduce disease burden and prolong survival in mice as well as prevent proliferation and promote activation of proapoptotic pathways in human tumors. Synonyms: CAL-130 Hydrochloride; CAL 130 Hydrochloride; CAL130 Hydrochloride;(S)-2-(1-((2-amino-9H-purin-6-yl)amino)ethyl)-5-methyl-3-(o-tolyl)quinazolin-4(3H)-one hydrochloride. Grades: >98%. CAS No. 1431697-78-7. Molecular formula: C23H23ClN8O. Mole weight: 462.93. |  |
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