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| Product | Description | |
|---|---|---|
| Calicheamicin | Calicheamicin, an antitumor antibiotic , is a cytotoxic agent that causes double-strand DNA breaks. Calicheamicin is a DNA synthesis inhibitor [1]. Calicheamicin is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Calicheamicin γ1. CAS No. 108212-75-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19609. |  |
| N-Acetyl calicheamicin | N-Acetyl calicheamicin is a derivative of calicheamicin, and is a potent enediyne antitumor antibiotic. Calicheamicins target DNA and cause strand scission. Calicheamicins bind with DNA in the minor groove, wherein they then undergo a reaction analogous to the Bergman cyclization to generate a diradical species. This diradical, 1,4-didehydrobenzene, then abstracts hydrogen atoms from the deoxyribose (sugar) backbone of DNA, which ultimately leads to strand scission. The specificity of binding of calicheamicin to the minor groove of DNA was demonstrated by Crothers et al. (1999) to be due to the aryltetrasaccharide group of the molecule. Uses: Designed for use in research and industrial production. Additional or Alternative Names: N-Acetyl calicheamicin; N-Acetyl-γ-calicheamicin; N-Acetylcalicheamicin γ. Product Category: Others. Appearance: Solid powder. CAS No. 108212-76-6. Molecular formula: C57H76IN3O22S4. Mole weight: 1410.38. Purity: >98%. IUPACName: S-((2R,3S,4S,6S)-6-((((2R,3S,4S,5R,6R)-5-(((2S,4S,5S)-5-(N-ethylacetamido)-4-methoxytetrahydro-2H-pyran-2-yl)oxy)-4-hydroxy-6-(((2S,5Z,9R,13Z)-9-hydroxy-12-((methoxycarbonyl)amino)-13-(2-(methyltrisulfanyl)ethylidene)-11-oxobicyclo[7.3.1]trideca-1(12),5-dien-3,7-diyn-2-yl)oxy)-2-methyltetrahydro-2H-pyran-3-yl)amino)oxy)-4-hydroxy-2-methyltetrahydro-2H-pyran-3-yl) 4-(((2S,3R,4R,5S,6S)-3,5-dihydroxy-4-methoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-3-iodo- |  |
| 4-Hydroxybenzyl Alcohol | 4-Hydroxybenzyl Alcohol is a reagent in the synthesis in a conjugate of calicheamicin used in the treatment of acute myeloid leukemia. Participates in the oxidation of phenols catalyzed by polyphenol oxidase. Also used in the preparation of antimalarial agents. Group: Biochemicals. Alternative Names: 4-Hydroxy Benzene methanol; p-Hydroxybenzyl Alcohol; (4-Hydroxyphenyl) methanol; 4-(Hydroxymethyl)phenol; 4-Hydroxy Benzene methanol; 4-Hydroxybenzyl Alcohol; 4-Methylolphenol; Gastrodigenin; NSC 227926; p-(Hydroxymethyl)phenol; p-2-Hydroxybenzyl Alcohol; p-Hydroxy Benzene methanol; p-Hydroxybenzyl Alcohol; p-Methoxytoluol; p-Methylolphenol; α-Hydroxy-p-cresol. Grades: Highly Purified. CAS No. 623-05-2. Pack Sizes: 25g. US Biological Life Sciences. |  Worldwide |
| Gemtuzumab | Gemtuzumab is a monoclonal IgG4-κ antibody targeting CD33 antigen, which present on leukemic myeloblasts of acute myeloid leukemia (AML). Gemtuzumab can be used for synthesis of antibody-drug conjugate (ADC) , Gemtuzumab ozogamicin (HY-109539). Gemtuzumab ozogamicin consists of a cytotoxic derivative of Calicheamicin (a cytotoxic antibiotic), and a monoclonal antibody. Gemtuzumab ozogamicin can be used for the research of acute myeloid leukemia [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 220578-59-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P99971. | |
| Gemtuzumab ozogamicin | Gemtuzumab ozogamicin is an antibody-drug conjugate (ADC) consisting of a humanized immunoglobulin (IgG4) antibody directed against CD33 that is conjugated to the cytotoxic agent Calicheamicin (HY-19609). Calicheamicin is a cytotoxic antibiotic. Gemtuzumab ozogamicin can be used for the research of acute myeloid leukemia (AML) [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 220578-59-6. Pack Sizes: 100 μg; 200 μg; 500 μg. Product ID: HY-109539. | |
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