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| Product | Description | |
|---|---|---|
| Calpain Inhibitor II | Calpain Inhibitor II. Group: Biochemicals. Grades: Highly Purified. CAS No. 110115-07-6. Pack Sizes: 5mg, 10mg, 25mg. US Biological Life Sciences. |  Worldwide |
| Calpain Inhibitor II | Calpain inhibitor II is a cell-permeable inhibitor of calpain I (Ki = 120 nM), calpain II (Ki = 230 nM), cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 600 pM). It inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Calpain inhibitor II can block nitric oxide production by interfering with transcription of the inducible nitric oxide synthase gene, which is a weak inhibitor of proteasome. It has been used to demonstrate the involvement of ubiquitin-proteasome protein degradation in various biological systems. Uses: Cysteine proteinase inhibitors. Synonyms: L-Leucinamide, N-acetyl-L-leucyl-N-[(1S)-1-formyl-3-(methylthio)propyl]-; L-Leucinamide, N-acetyl-L-leucyl-N-[1-formyl-3-(methylthio)propyl]-, (S)-; N-Acetyl-L-leucyl-N-[(1S)-1-formyl-3-(methylthio)propyl]-L-leucinamide; ALLM; Calp II; CI 2; SUAM 312; N-acetylleucyl-leucyl-methioninal; Ac-Leu-Leu-Met-al; N-acetyl-L-leucyl-L-leucyl-L-methioninal. Grades: ≥98%. CAS No. 110115-07-6. Molecular formula: C19H35N3O4S. Mole weight: 401.57. |  |
| Calpain Inhibitor II | powder. Group: Fluorescence/luminescence spectroscopy. |  |
| Calpain Inhibitor III | Calpain Inhibitor III. Group: Biochemicals. Grades: Highly Purified. CAS No. 88191-84-8. Pack Sizes: 25mg, 50mg, 100mg. US Biological Life Sciences. | Worldwide |
| Calpain Inhibitor III - CAS 88191-84-8 | The Calpain Inhibitor III, also referenced under CAS 88191-84-8, controls the biological activity of Calpain. This small molecule/inhibitor is primarily used for Protease Inhibitors applications. Group: Fluorescence/luminescence spectroscopy. | |
| MDL 28170, Z-Val-Phe-CHO, (Carbobenzoxy-valinyl-phenylalaninal, Calpain Inhibitor III) | A potent, cell-permeable, and selective inhibitor of calpain and cathepsin B (Ki values are 10 and 25nm respectively). MDL 28170 does not inhibit trypsin-like serine proteases. Rapidly penetrates the blood-brain barrier following systemic administration and displays neuroprotective effects in vivo. Modulates the formation of Ab formation by inhibiting the formation of intermediate Ab46 and protecting Ab from degradation. Group: Biochemicals. Grades: Highly Purified. CAS No. 88191-84-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ALLM | ALLM (Calpain inhibitor II) is a potent inhibitor of calpain and cathepsin proteases. ALLM inhibits neuronal cell death and improves chronic neurological function after spinal cord injury (SCI) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Calpain inhibitor II. CAS No. 110115-07-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-118355. |  |
| ALLM - CAS 110115-07-6 | Cell permeable inhibitor of calpain I (Ki = 120 nM), calpain II (Ki = 230 nM), cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 600 pM). Group: Fluorescence/luminescence spectroscopy. | |
| ALLN - CAS 110044-82-1 | Cell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM). Group: Fluorescence/luminescence spectroscopy. | |
| Biotin-LLY-FMK | Biotin-LLY-FMK is a biotin-labeled calpain inhibitor that can be used as a probe for detecting calpain II and cathepsin L by biotin ligand. Synonyms: Biotin-Leu-Leu-Tyr-Fluoromethylketone. Grades: ≥95%. Molecular formula: C32H48FN5O6S. Mole weight: 649.82. | |
| Calpastatin Peptide | A 27-amino acid, cell-permeable peptide encoded by exon 1B of human calpastatin that acts as a potent inhibitor of calpain I and calpain II (IC?? = 20 nM for purified rabbit calpain II). Group: Fluorescence/luminescence spectroscopy. | |
| Calpeptin | Calpeptin is a potent, cell-permeable calpain inhibitor with ID50 of 52 nM, 34 nM, 138 nM, and 40 nM for Calpain I (porcine erythrocytes), Calpain II (porcine kidney), Papainb, and Calpain I (human platelets), respectively. Uses: Cysteine proteinase inhibitors. Synonyms: Benzylcarbonyl-leu-nleu-H; Cbz-Leu-Nle-al. Grades: >98%. CAS No. 117591-20-5. Molecular formula: C20H30N2O4. Mole weight: 362.46. | |
| Fitc-LLY-FMK | FITC-LLY-FMK is a fluorescein isothiocyanate (FITC)-conjugated calpain inhibitor that can be used as a marker for detecting calpain II and cathepsin L in live cells. Synonyms: FITC-Leu-Leu-Tyr-Fluoromethylketone. Grades: ≥95%. Molecular formula: C43H45FN4O9S. Mole weight: 812.91. | |
| MDL 28170 | MDL 28170. Group: Biochemicals. Alternative Names: [ (1S) -1-[[ (1-Formyl-2-phenylethyl) amino]carbonyl]-2-methylpropyl]carbamic Acid Phenylmethyl Ester; Calp III; Calpain Inhibitor III. Grades: Highly Purified. CAS No. 88191-84-8. Pack Sizes: 25mg. Molecular Formula: C22H26N2O4, Molecular Weight: 382.45. US Biological Life Sciences. | Worldwide |
| MDL-28170 | MDL-28170 (Calpain Inhibitor III) is a potent, selective and membrane-permeable cysteine protease inhibitor of calpain that rapidly penetrates the blood-brain barrier following systemic administration [1] [2]. MDL-28170 also block γ-secretase [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Calpain Inhibitor III. CAS No. 88191-84-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18236. | |
| MG-101 | MG-101 (ALLN) is an inhibitor of cysteine proteases which inhibits calpain I, calpain II, cathepsin B and cathepsin L with K i s of 190, 220, 150 and 500 pM, respectively. MG-101 induces apoptosis and inhibits tumor growth, it can be used for the research of colon cancer [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Calpain inhibitor I; Ac-LLnL-CHO; ALLN. CAS No. 110044-82-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18964. | |
| Z-LLY-FMK | Z-LLY-FMK is a cell-permeant and irreversible calpain inhibitor that is selective for calpain II, and also exhibits inhibitory effect against cathepsin L. It was shown to suppress hepatocyte apoptosis after bile duct ligation in rat. Synonyms: Calpain Inhibitor IV; Z-Leu-Leu-Tyr-FMK; Z-Leu-Leu-Tyr-Fluoromethylketone; N-[(benzyloxy)carbonyl]-L-leucyl-N-[(1S)-3-fluoro-1-(4-hydroxybenzyl)-2-oxopropyl]-L-leucinamide. Grades: ≥95%. CAS No. 133410-84-1. Molecular formula: C30H40FN3O6. Mole weight: 557.66. | |
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