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| Product | Description | |
|---|---|---|
| Canertinib dihydrochloride | Canertinib dihydrochloride (CI-1033 dihydrochloride) is a potent and irreversible EGFR inhibitor; inhibits cellular EGFR and ErbB2 autophosphorylation with IC 50 s of 7.4 and 9 nM. Canertinib dihydrochloride is active against vaccinia virus respiratory infection in mice [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CI-1033 dihydrochloride; PD-183805 dihydrochloride. CAS No. 289499-45-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-10367A. |  |
| Canertinib dihydrochloride | Canertinib dihydrochloride is the hydrochloride salt of an orally bio-available quinazoline with potential antineoplastic and radiosensitizing activities. Canertinib binds to the intracellular domains of epidermal growth factor receptor tyrosine kinases (ErbB family), irreversibly inhibiting their signal transduction functions and resulting in tumor cell apoptosis and suppression of tumor cell proliferation. This agent also acts as a radiosensitizing agent and displays synergistic activity with other chemotherapeutic agents. Uses: Antineoplastic agents. Synonyms: N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(3-(morpholin-4-yl)propoxy)quinazolin-6-yl)prop-2-enamide; CI1033PD183805. Grades: ≥98% (HPLC). CAS No. 289499-45-2. Molecular formula: C24H27Cl3FN5O3. Mole weight: 558.86. |  |
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