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| Product | Description | |
|---|---|---|
| Canfosfamide | Canfosfamide hydrochloride is the hydrochloride salt of a modified glutathione analogue with potential antineoplastic activity. Canfosfamide is selectively activated by glutathione S-transferase P1-1 into an alkylating metabolite that forms covalent linkages with nucleophilic centers in tumor cell DNA, which may induce a cellular stress response and cytotoxicity, and decrease tumor proliferation. S-transferase P1-1 is an enzyme that is overexpressed in many human malignancies. Synonyms: TELCYTA; TLK286; TLK 286; TLK-286. CAS No. 158382-37-7. Molecular formula: C26H40Cl4N5O10PS. Mole weight: 787.47. |  |
| Canfosfamide Hydrochloride | Canfosfamide is a modified glutathione analogue as a small-molecule antineoplastic compound with potential antineoplastic activity. Canfosfamide is selectively activated by glutathione S-transferase P1-1 into an alkylating metabolite that forms covalent linkages with nucleophilic centers in tumor cell DNA, which may induce a cellular stress response and cytotoxicity, and decrease tumor proliferation. S-transferase P1-1 is an enzyme that is overexpressed in many human malignancies. Uses: Glutathione transferase inhibitor. Synonyms: Telcyta; TER 286; TLK 286; TER286; TLK286; TER-286; TLK-286; N5- ( ( (2- ( (bis (bis (2-chloroethyl) amino) phosphoryl) oxy) ethyl) sulfonyl) -D-alanyl) -N5- ( (R) -carboxy (phenyl) methyl) -L-glutamine hydrochloride. Grades: ≥98%. CAS No. 439943-59-6. Molecular formula: C26H41Cl5N5O10PS. Mole weight: 823.93. | |
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