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| Product | Description | |
|---|---|---|
| Capsazepine | Capsazepine, a benzazepine derivative, has been found to be a sensory neurone excitotoxin that could be used against hyperalgesic responses. IC50: 562 nM (Rat TRPV1). Uses: Capsazepine has been found to be a sensory neurone excitotoxin that could be used against hyperalgesic responses. Synonyms: N-[2-(4-Chlorophenyl)ethyl]-1,3,4,5-tetrahydro-7,8-dihydroxy-2H-2-benzazepine-2-carbothioamide. Grades: > 95%. CAS No. 138977-28-3. Molecular formula: C19H21ClN2O2S. Mole weight: 376.91. |  |
| Capsazepine | Capsazepine. Group: Biochemicals. Grades: Purified. CAS No. 138977-28-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| Capsazepine (N-[2-(4-Chlorophenyl)ethyl]-1,3,4,5-tetrahydro-7,8-dihydroxy-2H-2-benzazepine-2-carbothioamide) | A selective vanilloid receptor antagonist (Ki=3.2uM). Group: Biochemicals. Alternative Names: N-[2-(4-Chlorophenyl)ethyl]-1,3,4,5-tetrahydro-7,8-dihydroxy-2H-2-benzazepine-2-carbothioamide. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 5'-Iodoresiniferatoxin | 5'-Iodoresiniferatoxin is a very potent and strong competitive antagonist of the transient receptor potential vanilloid 1 (TRPV1) receptor. It is derived from resiniferatoxin (RTX), which is produced by the Moroccan succulent Euphorbia resinifera. It is iodinated at the 5-position and can be prepared from RTX by electrophilic aromatic substitution. It binds to TRPV1 (VR1) receptors expressed in HEK293 cells with Kd value of 4.3 nM and Ki value of 5.8 nM. It binds to the VR1 receptor with high affinity but does not induce RTX- or capsaicin-like effects in Xenopus laevis oocytes expressing VR1. It is 40-fold more potent than capsazepine. Synonyms: 5-I-RTX; 5'-IRTX; 6,7-Deepoxy-6,7-didehydro-5-deoxy-21-dephenyl-21-(phenylmethyl)-daphnetoxin,20-(4-hydroxy-5-iodo-3-methoxybenzeneacetate). Grades: ≥98% by HPLC. CAS No. 535974-91-5. Molecular formula: C37H39IO9. Mole weight: 754.60. | |
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