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| Product | Description | |
|---|---|---|
| Carboxyamidotriazole | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| Carboxyamidotriazole | Carboxyamidotriazole is an orally active calcium channel blocker. Carboxyamidotriazole also exhibits inhibition of pro-inflammatory cytokines in tumor associated macrophages as potential anti-cancer mechanism. Group: Biochemicals. Alternative Names: 5-Amino-1-[[3, 5-dichloro-4- (4-chlorobenzoyl) phenyl]methyl]-1H-1, 2, 3-triazole-4-carboxamide; L 651582; NSC 609974; CAI. Grades: Highly Purified. CAS No. 99519-84-3. Pack Sizes: 25mg. US Biological Life Sciences. |  Worldwide |
| Carboxyamidotriazole | Carboxyamidotriazole (L-651582) is an orally active cytostatic inhibitor of nonvoltage-operated calcium channels and calcium channel-mediated signaling pathways. Carboxyamidotriazole inhibits NF-κB , MAPK activation and NO production. Carboxyamidotriazole has anti-angiogenic and anti-inflammatory activities. Carboxyamidotriazole has anticancer activity against liver cancer, lung cancer and leukemia [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [11] [12] [13]. Uses: Scientific research. Group: Natural products. Alternative Names: L-651582; CAI. CAS No. 99519-84-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16126. |  |
| Carboxyamidotriazole orotate | Carboxyamidotriazole orotate (CTO) is the orotate salt form of carboxyamidotriazole (CAI), an orally bioavailable small molecule with potential antiangiogenic and antiproliferative activities. Carboxyamidotriazole binds to and inhibits non-voltage-operated calcium channels, blocking both Ca2+ influx into cells and Ca2+ release from intracellular stores, resulting in the disruption of calcium channel-mediated signal transduction. CAI inhibits PI3 activity and vascular endothelial growth factor (VEGF) signaling. This may inhibit endothelial proliferation, tumor cell growth, invasion and metastasis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). Synonyms: L-651582 Orotate; CAI Orotate; CTO; 4-Pyrimidinecarboxylic acid, 1,2,3,6-tetrahydro-2,6-dioxo-, compd. with 5-amino-1-[[3,5-dichloro-4-(4-chlorobenzoyl)phenyl]methyl]-1H-1,2,3-triazole-4-carboxamide (1:1); 2,6-Dioxo-1,2,3,6-tetrahydro-4-pyrimidinecarboxylic acid 5-amino-1-[3,5-dichloro-4-(4-chlorobenzoyl)benzyl]-1H-1,2,3-triazole-4-carboxamide (1:1). Grades: ≥90%. CAS No. 187739-60-2. Molecular formula: C22H16Cl3N7O6. Mole weight: 580.76. |  |
| Carboxyamidotriazole Orotate | Carboxyamidotriazole Orotate (L-651582 Orotate) is the orotate salt form of Carboxyamidotriazole (CAI), an orally bioavailable signal transduction inhibitor. Carboxyamidotriazole Orotate is a cytostatic inhibitor of nonvoltage-operated calcium channels and calcium channel-mediated signaling pathways. Carboxyamidotriazole Orotate shows anti-tumor, anti-inflammatory and antiangiogenic effects [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: L-651582 Orotate; CAI Orotate. CAS No. 187739-60-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16125. | |
| Cai | Cai. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Carboxyamidotriazole, Carboxyamido-triazole, 4-CAI, NCIStruc1_001699, NCIStruc2_001836, NSC609974, C17H12Cl3N5O2, RFE-007, AIDS096375, NSC 609974, NSC-609974, AIDS-096375, CID108144, NCGC00014926, NCI609974, ZINC00538116, NCGC00098026-01, NCI60_004782, L 651582, L-651582. Product Category: Heterocyclic Organic Compound. CAS No. 99519-84-3. Molecular formula: C17H12Cl3N5O2. Mole weight: 424.67. Purity: >98 %. IUPACName: 5-amino-1-[[3,5-dichloro-4-(4-chlorobenzoyl)phenyl]methyl]triazole-4-carboxamide. Density: 1.65g/cm³. Product ID: ACM99519843. Alfa Chemistry ISO 9001:2015 Certified. |  |
| L-651,582 | L-651,582 is a novel inhibitor of both cAMP-phosphodiesterases and GMP-phosphodiesterases. It is also an orally active calcium channel blocker. It prevents oxidative phosphorylation in cancer cells and exhibits inhibition of pro-inflammatory cytokines in tumor associated macrophages. It may be used as a potential anti-cancer drug. It ameliorates experimental colitis by inhibiting nuclear factor-κB activation, colonic fibrosis and cytokine production. It has antimetastatic, antiangiogenic and antiproliferative activity in vivo. It displays selectivity towards numerous mismatch repair-deficient tumor cell lines in vitro. It blocks intracellular and mitochondrial calcium entry and flux, resulting in inhibition of calcium-release-activated calcium channel (CRAC) function, cell proliferation and maintenance of mitochondrial membrane potential. Synonyms: Carboxyamidotriazole; CAI; RFE-007; NSC-609974; L-651582; RFE007; NSC609974; L651582; 5-Amino-1-[[3,5-dichloro-4-(4-chlorobenzoyl)phenyl]methyl]-1H-1,2,3-triazole-4-carboxamide. Grades: ≥98% by HPLC. CAS No. 99519-84-3. Molecular formula: C17H12Cl3N5O2. Mole weight: 424.67. | |
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