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| Product | Description | |
|---|---|---|
| CCG-1423 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| CCG-1423 | CCG-1423 is an inhibitor of Rho/MRTF/SRF pathway. CCG-1423 shows activities in several cancer cells. CCG-1423 is a promising lead compound for the development of novel pharmacologic tools, and it can be used for the research of cancer and diabetes [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 285986-88-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-13991. |  |
| CCG-1423 | CCG-1423 is a potent inhibitor of RhoA/C-mediated gene transcription. It suppressed invasion of PC-3 prostate cancer cells in a matrigel model of metastasis. It induces intermediate mesoderm differentiation from ESCs. Synonyms: CCG 1423; N-[1-(4-chloroanilino)-1-oxopropan-2-yl]oxy-3,5-bis(trifluoromethyl)benzamide. Grades: >98%. CAS No. 285986-88-1. Molecular formula: C18H13ClF6N2O3. Mole weight: 454.75. |  |
| (R)-CCG-1423 | (R)-CCG-1423 is a stereoisomer of CCG-1423, a Rho inhibitor that blocks signaling through myocardin-related transcription factor A (MRTF-A) and serum response factor (SRF). Synonyms: (R)-N-((1-((4-chlorophenyl)amino)-1-oxopropan-2-yl)oxy)-3,5-bis(trifluoromethyl)benzamide. Grades: ≥98%. Molecular formula: C18H13ClF6N2O3. Mole weight: 454.8. | |
| Rho/SRF Pathway Inhibitor, CCG-1423 - CAS 285986-88-1 | The Rho/SRF Pathway Inhibitor, CCG-1423, also referenced under CAS 285986-88-1, controls the biological activity of Rho/SRF. This small molecule/inhibitor is primarily used for Cell Structure applications. Group: Fluorescence/luminescence spectroscopy. | |
| Rho/SRF Pathway Inhibitor, CCG-1423 (N- (2- (4-Chloroanilino) -1-methyl-2-oxoethoxy) -3, 5-bis (trifluoromethyl) benzamide) | A cell-permeable benzamide compound that acts as an effective inhibitor against RhoA- and RhoC-mediated cellular activities by targeting signaling events downstream of Ga12/13 and RhoA/C, affecting MKL recruitment and/or postrecruitment function of MKL1, but not SRF-SRE interaction or ROCK kinase activity. CCG-1423 is shown to inhibit RhoC-dependent cell growth in A375M2 and SK-Mel-147 (IC50≤300nM) and block RhoC/ Ga12-mediated PC-13 invasion in Matrigel assays (by ~90% at 3uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 285986-88-1. Pack Sizes: 25mg. US Biological Life Sciences. |  Worldwide |
| (S)-CCG-1423 | (S)-CCG-1423 is a stereoisomer of CCG-1423, a Rho inhibitor that blocks signaling through myocardin-related transcription factor A (MRTF-A) and serum response factor (SRF). Synonyms: (S)-N-((1-((4-chlorophenyl)amino)-1-oxopropan-2-yl)oxy)-3,5-bis(trifluoromethyl)benzamide. Grades: ≥98%. Molecular formula: C18H13ClF6N2O3. Mole weight: 454.8. | |
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