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| Product | Description | |
|---|---|---|
| CCT128930 | CCT128930 is a ATP-competitive and selective inhibitor of AKT (IC50=6 nM for AKT2). CCT128930 has 28-fold selectivity over the closely related PKA kinase (IC50=168 nM) through the targeting of Met282 of AKT (Met173 of PKA-AKT chimera), as well as 20-fold selectivity over p70S6K (IC50=120 nM). Antitumor activity. Uses: Scientific research. Group: Signaling pathways. CAS No. 885499-61-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13260. |  |
| CCT128930 | CCT128930 is a novel ATP-competitive AKT inhibitor discovered using fragment- and structure-based approaches. It is a potent, advanced lead pyrrolopyrimidine compound exhibiting selectivity for AKT over PKA, achieved by targeting a single amino acid difference. CCT128930 exhibited marked antiproliferative activity and inhibited the phosphorylation of a range of AKT substrates in multiple tumor cell lines in vitro, consistent with AKT inhibition. Synonyms: CCT128930; CCT-128930; CCT 128930. CAS No. 885499-61-6. Molecular formula: C18H20ClN5. Mole weight: 341.8379. |  |
| CCT128930 hydrochloride | CCT128930 hydrochloride is a potent and selective inhibitor of AKT (IC50 = 6 nM). CCT128930 hydrochloride also induces cell cycle arrest, DNA damage, and autophagy. Synonyms: 4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-amine hydrochloride. Grade: 98%. CAS No. 2453324-32-6. Molecular formula: C18H21Cl2N5. Mole weight: 378.30. | |
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