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| Product | Description | |
|---|---|---|
| Centrinone | Centrinone, a pyrimidinamine derivative, has been found to be a high affinity and selective PLK4 inhibitor (Ki = 0.16 nM). Synonyms: Centrinone; LCR-263; LCR 263; LCR263. 2-[[2-Fluoro-4-[[ (2-fluoro-3-nitrophenyl) methyl]sulfonyl]phenyl]thio]-5-methoxy-N- (5-methyl-1H-pyrazol-3-yl) -6- (4-morpholinyl) -4-pyrimidinamine. Grades: ≥98% by HPLC. CAS No. 1798871-30-3. Molecular formula: C26H25F2N7O6S2. Mole weight: 633.65. |  |
| Centrinone B | Centrinone B, has been found to be a high affinity and selective PLK4 inhibitor (Ki: 0.6 nM) and exhibit more than 2000-fold selectivity for PLK4 over Aurora A and Aurora B. Synonyms: Centrinone-B; Centrinone B; CentrinoneB; LCR-323; LCR 323; LCR323; 2-[[2-Fluoro-4-[[ (2-fluoro-3-nitrophenyl) methyl]sulfonyl]phenyl]thio]-5-methoxy-N- (5-methyl-1H-pyrazol-3-yl) -6- (1-piperidinyl) -4-pyrimidinamine. Grades: ≥98% by HPLC. CAS No. 1798871-31-4. Molecular formula: C27H27F2N7O5S2. Mole weight: 631.67. | |
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