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| Product | Description | |
|---|---|---|
| Ceranib 1 | Ceranib 1. Group: Biochemicals. Grades: Purified. CAS No. 328076-61-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| Ceranib 1 | Ceranib 1 is a ceramidase inhibitor. It inhibits proliferation in SKOV3 ovarian carcinoma cells. It decreases sphingosine and sphingosine-1-phosphate (S1P) levels in SKOV3 cells and induces accumulation of ceramide species. It is a useful research chemical and has an antiproliferative effect. Synonyms: 3-[(2E)-3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-6-methyl-4-phenyl-2(1H)-quinolinone; 6-Methyl-3-[3-(4-methoxyphenyl)-1-oxo-2-propenyl]-4-phenyl-2(1H)-quinolinone. Grades: ≥98% by HPLC. CAS No. 328076-61-5. Molecular formula: C26H21NO3. Mole weight: 395.45. |  |
| Ceranib-2 (3- (3- (4-methoxyphenyl) acryloyl) -4-phenylquinolin-2 (1H) -one, Ceranib 2, Ceranib2) | A cell-permeable, potent inhibitor of ceramidase (IC50=28mM) with anti-proliferative and proapoptotic properties. Shown to block the proliferation of SKVO3, ovarian adenocarcinma cells (IC50=730nM) in the G2/M phase. When used in combination with paclitaxel, it increases tumor chemosentitvity and exhibits additive chemotherapeutic effects. Reduces tumor burden in Balb/c mice when administered intraperitoneally (20-50mg/kg) without affecting the total body weight. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??NO?, Molecular Weight: 381.4. US Biological Life Sciences. | Worldwide |
| Ceranib-2 | Ceranib-2 is an inhibitor of cellular ceramidase activity, which can inhibit ceramidase activity with IC50 of 28 μM in SKOV3 cells. It can catalyze the hydrolysis of the N-acyl linkage between the fatty acid and sphingosine base in ceramide to produce sphingosine and a free fatty acid. Ceranib-2 decreases levels of sphingosine and sphingosine-1-phosphate (S1P), and inhibits cell proliferation. Grades: ≥98%. CAS No. 1402830-75-4. Molecular formula: C25H19NO3. Mole weight: 381.4. | |
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