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| Product | Description | |
|---|---|---|
| Cerdulatinib | Cerdulatinib, also known as PRT2070 and PRT062070, is a novel, oral, dual spleen tyrosine kinase (Syk) and janus kinase (JAK) inhibitor. Cerdulatinib preferentially inhibited JAK1 and JAK3 dependent cytokine mediated signaling and functional responses in various cell types. IL2 mediated STAT5 Y694 was inhibited with an IC50 of 0.27uM, while IL4 mediated signaling to STAT6 Y641 and functional responses in B cells and monocytes, namely CD69, CD25, and CD23 up-regulation, were inhibited with IC50 within the range of 0.11uM to 0.57uM. It is currently being studied in patients with genetically-defined hematologic cancers, as well as for patients who have failed therapy due to relapse or acquired mutations. Synonyms: Cerdulatinib; PRT2070; PRT-2070; PRT 2070; PRT-062070; PRT 062070; PRT062070. CAS No. 1198300-79-6. Molecular formula: C20H27N7O3S. Mole weight: 445.542. |  |
| Cerdulatinib | Cerdulatinib (PRT062070) is a selective Tyk2 inhibitor with an IC 50 of 0.5 nM. Cerdulatinib (PRT062070) also is a dual JAK and SYK inhibitor with IC 50 s of 12, 6, 8 and 32 for JAK1, 2, 3 and SYK, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PRT062070; PRT2070. CAS No. 1198300-79-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-15999. |  |
| Cerdulatinib HCl | Cerdulatinib is a dual SYK/JAK inhibitor. It significantly reduces cell viability in a subset of NHL cell lines, and induces apoptosis in BCR-signaling competent NHL cell lines. Synonyms: Cerdulatinib hydrochloride; PRT2070 hydrochloride; 4-(cyclopropylamino)-2-[4-(4-ethylsulfonylpiperazin-1-yl)anilino]pyrimidine-5-carboxamide hydrochloride. Grades: >98%. CAS No. 1369761-01-2. Molecular formula: C20H28ClN7O3S. Mole weight: 482. | |
| Cerdulatinib hydrochloride | Cerdulatinib hydrochloride (PRT062070) is a selective, oral active and reversible ATP-competitive inhibitor of dual SYK and JAK , with IC 50 s of 32 nM, 0.5 nM, 12 nM, 6 nM and 8 nM for SYK and Tyk2 , JAK1 , 2 , 3 , respectively. Cerdulatinib hydrochloride could be used to research autoimmune disease and B-cell malignancies [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PRT062070 hydrochloride; PRT2070 hydrochloride. CAS No. 1369761-01-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15999A. | |
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