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| Product | Description | |
|---|---|---|
| Ceritinib | An anaplastic lymphoma kinase (ALK)-positive inhibitor used for the treatment of non-small cell lung cancer (NSCLC). It less potently inhibits IGF-1R, InsR, and STK22D and IC50 value is 8, 7, and 23 nM. LDK378 is also minimally effective against a panel of other kinases. In Sep 2016, Interim adverse events and efficacy data from phase III ASCEND-4 trial in non small cell lung cancer released by Novartis. In Oct 2016, efficacy data from the phase III ASCEND-3 and ASCEND-5 trial in non small cell lung cancer was presented. Uses: Antineoplastic agents. Synonyms: 5-Chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine, LDK-378, LDK378; LDK 378; Zykadia; NVP-LDK378-NX. Grades: ≥98%. CAS No. 1032900-25-6. Molecular formula: C28H36ClN5O3S. Mole weight: 558.14. |  |
| Ceritinib | Ceritinib. Group: Biochemicals. Alternative Names: LDK 378. Grades: Highly Purified. CAS No. 1032900-25-6. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C28H36CIN5O3S. US Biological Life Sciences. |  Worldwide |
| Ceritinib | Ceritinib (LDK378) is a selective, orally bioavailable, and ATP-competitive ALK tyrosine kinase inhibitor with an IC 50 of 200 pM. Ceritinib (LDK378) also inhibits IGF-1R , InsR , and STK22D with IC 50 values of 8, 7, and 23 nM, respectively. Ceritinib (LDK378) shows great antitumor potency [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LDK378. CAS No. 1032900-25-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g; 2 g; 5 g. Product ID: HY-15656. |  |
| Ceritinib dihydrochloride | Ceritinib dihydrochloride (LDK378 dihydrochloride) is a selective, orally bioavailable and ATP-competitive ALK tyrosine kinase inhibitor with an IC 50 of 200 pM. Ceritinib dihydrochloride (LDK378 dihydrochloride) also inhibits IGF-1R , InsR , and STK22D with IC 50 values of 8, 7, and 23 nM, respectively. Ceritinib dihydrochloride (LDK378 dihydrochloride) shows great antitumor potency [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LDK378 dihydrochloride. CAS No. 1380575-43-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15656A. | |
| LDK378 dihydrochloride | Ceritinib, also known as LDK378, is a selective inhibitor of ALK1, a target found in metastatic non-small cell lung cancer (NSCLC). In Phase I trials, LDK378 showed a marked clinical response in 78 patients with anaplastic lymphoma kinase positive (ALK+) metastatic non-small cell lung cancer (NSCLC) who had progressed during or after crizotinib therapy or had not been previously treated with crizotinib. LDK378 blocks the ALK protein and stops it sending growth signals to cancer cells, which may stop them growing. Synonyms: LDK 378 dihydrochloride; LDK-378 dihydrochloride; LDK378 dihydrochloride; Ceritinib dihydrochloride. Grades: >98%. CAS No. 1380575-43-8. Molecular formula: C28H38Cl3N5O3S. Mole weight: 631.06. | |
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