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| Product | Description | |
|---|---|---|
| Cerulenin | Cerulenin, a potent, natural inhibitor of fatty acid synthase (FASN), is an epoxide produced by the fungus Cephalosporium caeruleus. Cerulenin inhibits topoisomerase I catalytic activity and augments SN-38-induced apoptosis. Cerulenin has antifungal and antitumor activies. Group: Inhibitors. Alternative Names: 2,3-Epoxy-4-oxo-7,10-dodecadienamide. CAS No. 17397-89-6. Molecular formula: C12H17NO3. Mole weight: 223.27. Appearance: Off-white solid. Purity: 0.98. IUPACName: (2R,3S)-3-[(4E,7E)-nona-4,7-dienoyl]oxirane-2-carboxamide. Canonical SMILES: C/C=C/C/C=C/CCC (=O)[C@@H]1[C@@H] (O1)C (=O)N. Catalog: ACM17397896. |  |
| Cerulenin | It is produced by the strain of Cephctlosporium caerulene, Helicoceras oryzae, Acrooylindrium oryzae. It has weak antibacterial activity, but it has the effect of resisting yeast, ringworm epidermis, pear spore and mycoplasma. It can inhibit the biosynthesis of fatty acids and sterols, and also inhibit the biosynthesis of Polyketide. In recent years, it has been found to inhibit HIV. Uses: Antifungal agents. Synonyms: Cerulenin; Helicocerin; 2,3-Epoxy-4-oxo-7,10-dodecadienamide; 3-(1-Oxo-4,7-nonadienyl)oxiranecarboxamide. Grades: 98%. CAS No. 17397-89-6. Molecular formula: C12H17NO3. Mole weight: 223.27. |  |
| Cerulenin (2,3-Epoxy-4-oxo-7,10-dodecadienamide) | Antibiotic. Fatty acid synthase (FAS) inhibitor, reported to bind in equimolar ratio to B-keto-acyl- ACP synthase, thus inhibiting protein acylation. Produces metabolic effects similar to effects of leptin, but through mechanisms that are independent of, or down-stream from, both leptin and melanocortin receptors. Apoptosis inducer. Inhibitor of bacterial fatty acid synthesis (inhibits FabH, FabB and FabF condensation enzymes). Group: Biochemicals. Grades: Highly Purified. CAS No. 17397-89-6. Pack Sizes: 5mg. Molecular Formula:C12H17NO3 MOLECULAR WEIGHT: 223.3. US Biological Life Sciences. |  Worldwide |
| Cerulenin (Helicocerin, NSC 116069, 2,3-Epoxy-4-oxo-7,10-dodecadienamide) | Cerulenin is an epoxy fatty acid amide isolated from the fungus Cephalosporium caerulens and identified as an antifungal in the 1960s. Over the past 40 years cerulenin has found broad application in lipid biochemistry as an inhibitor fatty acid and sterol biosynthesis. Cerulenin binds to B-keto-acyl-ACP synthase blocking the interaction of malonyl CoA. Cerulenin is also an inhibitor of bacterial fatty acid synthesis acting on the FabH, FabB and FabF condensation enzymes. Cerulenin stimulates fatty acid oxidation and inhibits HMG-CoA synthetase activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 17397-89-6. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Native Bacillus amyloliquefaciens Protease | Bacterial protease produced by submerged fermentation of a selected strain of Bacillus amyloliquefaciens. Secretion of protease by Bacillus amyloliquefaciens can be inhibited by treatment with the fatty acid synthetase inhibitor cerulenin. Bacterial protease produced by submerged fermentation of a selected strain of bacillus amyloliquefaciens. secretion of protease by bacillus amyloliquefaciens can be inhibited by treatment with the fatty acid synthetase inhibitor cerulenin. Applications: Protease from bacillus amyloliquefaciens has been used for the unhairing of hides and skins. it has also been used in a study to investigate peptide bond formation using the carbamoylmethyl ester as the acyl donor. Group: Enzymes. Synonyms: Protease; Neutrase. CAS No. 9001-92-7. Protease. Form: liquid, > 0.8 U/g. Source: Bacillus amyloliquefaciens. Protease; Neutrase. Cat No: NATE-0632. |  |
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