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| Product | Description | |
|---|---|---|
| Cevipabulin | Cevipabulin, is a small synthetic molecule of triazolopyrimidine derivative with potential antitumor activity. With a novel mechanism of action distinct from the action of other vinca alkaloid compounds, it specifically binds to tubulin at the vinca site, and promotes the polymerization of tubulin into microtubules. Cebipabulin stabilizes tubulin and inhibits microtubule disassembly. This results in cell cycle arrest at the G2/M phase, and leading to cell death. Synonyms: TTI 237; TTI237; TTI237; D06576. CAS No. 849550-05-6. Molecular formula: C18H18ClF5N6O. Mole weight: 464.825. |  |
| Cevipabulin | Cevipabulin (TTI-237) is an oral, microtubule-active antitumor compound and inhibits the binding of [ 3 H] vinblastine to tubulin, with an IC 50 of 18-40 nM for cytotoxicity in human tumor cell line [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TTI-237. CAS No. 849550-05-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14949. |  |
| Cevipabulin fumarate | Cevipabulin fumarate (TTI-237 fumarate) is an oral, microtubule-active, antitumor compound and inhibits the binding of [ 3 H]NSC 49842 to tubulin, with an IC 50 of 18-40 nM for cytotoxicity in human tumor cell line [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TTI-237 fumarate. CAS No. 849550-67-0. Pack Sizes: 10 mM * 1ML; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14949C. | |
| Cevipabulin succinate | Cevipabulin is a Tubulin polymerisation inhibitor. It can bind to tubulin at the vinca site and promote the polymerization of tubulin into microtubules. Cevipabulin can stabilize tubulin and inhibit microtubule disassembly. This leads to cell cycle arrest at the G2/M phase. Phase I clinical trials for the treatment of solid tumor were discontinued. Uses: Solid tumours. Synonyms: TTI237; TTI 237; TTI-237; D06576; D 06576; D-06576; 5-chloro-6-(2,6-difluoro-4-(3-(methylamino)propoxy)phenyl)-N-((1S)-2,2,2-trifluoro-1-methylethyl)(1,2,4)triazolo(1,5-a)pyrimidin-7-amine (1:1), dihydrate. Grades: 98%. CAS No. 852954-81-5. Molecular formula: C18H18ClF5N6O. Mole weight: 618.94. | |
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