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Cell permeable potent inhibitor of protein kinase C. Does not inhibit tyrosine protein kinases, cAMP-dependent protein kinase or calcium/calmodulin-dependent protein kinase. Antiplatelet, anti-inflammatory, antibacterial and antitumor compound. Apoptosis inducer in cancer cells in vitro and in vivo. Activates MAPK and JUNK signaling pathways. Affects translocation of PKC from cytosol to plasma membrane. Neurite outgrowth stimulator. Inhibits binding of BclXL to Bak (IC50 =1.5uM) or Bad proteins and stimulates apoptosis in several cancer cell lines. Blocks human P2X7 receptor. Induces cell cycle arrest in G1 phase. Specific cyclooxygenase-2 inhibitor. Group: Biochemicals. Alternative Names: NSC 36405, 1,2-Dimethoxy-N-methyl-[1,3]benzodioxolo[5,6-c]phenanthridinium chloride. Grades: Highly Purified. CAS No. 3895-92-9. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C21H18ClNO4. US Biological Life Sciences.
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Chelerythrine chloride
Chelerythrine chloride is a potent, cell-permeable inhibitor of protein kinase C, with an IC50 of 660 nM. Chelerythrine chloride inhibits the Bcl-XL-Bak BH3 peptide binding with IC50 of 1.5 μM and displaces Bax from Bcl-XL. Chelerythrine chloride induces apoptosis and autophagy. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 1,2-Dimethoxy-12-methyl-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridin-12-ium chloride. Product Category: Inhibitors. CAS No. 3895-92-9. Mole weight: 383.8. Purity: 95%+. Product ID: ACM3895929. Alfa Chemistry ISO 9001:2015 Certified.
Chelerythrine chloride
Chelerythrine chloride is a potent, cell-permeable inhibitor of protein kinase C , with an IC 50 of 660 nM. Chelerythrine chloride inhibits the Bcl-XL-Bak BH3 peptide binding with IC 50 of 1.5 μM and displaces Bax from Bcl-XL. Chelerythrine chloride induces apoptosis and autophagy. Uses: Scientific research. Group: Natural products. CAS No. 3895-92-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12048.
Chelerythrine is a natural alkaloid, acts as a potent and selective Ca2+/phospholopid-dependent PKC antagonist, with an IC50 of 0.7 μM. Chelerythrine has antitumor, antidiabetic and anti-inflammatory activity. Chelerythrine inhibits the BclXL-Bak BH3 peptide binding with IC50 of 1.5 μM and displaces Bax from BclXL. Chelerythrine triggers apoptosis and autophagy. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Broussonpapyrine; Cheleritrine; Chelerythrin; Chelerythrine chloride; Chelerythrin-Kation; Chelerythrine; Chelerythrin chlorid. Product Category: Inhibitors. CAS No. 34316-15-9. Molecular formula: C21H18ClNO4. Mole weight: 348.83. Purity: 95%-99%. IUPACName: 1,2-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium. Canonical SMILES: C[N+]1=C2C(=C3C=CC(=C(C3=C1)OC)OC)C=CC4=CC5=C(C=C42)OCO5. ECNumber: 251-930-0. Product ID: ACM34316159. Alfa Chemistry ISO 9001:2015 Certified.
Macleaya cordata extract
Macleaya cordata extract. Uses: Designed for use in research and industrial production. Additional or Alternative Names: chelerythrine chloride-sanguinarine chloride mixt.;Macleaya cordata extract;13-Methyl-[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium chloride mixt. with 1,2-dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridinium chloride;13-Methyl-[1,3]. Product Category: Heterocyclic Organic Compound. CAS No. 112025-60-2. Molecular formula: C20H14NO4.Cl;C21H18NO4.Cl. Mole weight: N/A. Product ID: ACM112025602. Alfa Chemistry ISO 9001:2015 Certified.
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