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Product
Chetomin Chetomin. Group: Biochemicals. Grades: Purified. CAS No. 1403-36-7. Pack Sizes: 1mg. US Biological Life Sciences. USBiological 5
Worldwide
Chetomin from Chaetomium cochliodes, ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. Alfa Chemistry Analytical Products 2
Chetomin It is produced by the strain of Chaetomium cochloides , Ch.globosum, Ch.fuunienlum, Ch.elatun, Ch.spirale and Verticillium cinnabarium. Chetomin is a natural metabolite produced by several species of the genus chaetomium. It is an epidithiodioxopiperazine and is an inhibitor of hypoxia-inducible factor (HIF). It inhibits interaction of HIF1α and HIF2α with transcriptional co-activators p300 and cAMP response element binding (CREB) protein (CBP). It decreases tumor growth by attenuating hypoxia-inducible transcription and disrupting the ability of tumors to adapt to hypoxia. It also suppresses the proliferation of LPS-induced mouse spleen lymphocytes. It may be used as an antibacterial agent and is used in antitumor research. It also may be useful in radiotherapeutic. Synonyms: CTM; NSC-289491; NSC 289491; NSC289491; Chaetomin; (3S,5aR,10bS,11aS)-2,3,5a,6,10b,11-Hexahydro-3-(hydroxymethyl)-10b-[(1S,4S)-3-[[4-(hydroxymethyl)-5,7-dimethyl-6,8-dioxo-2,3-dithia-5,7-diazabicyclo[2.2.2]oct-1-yl]methyl]-1H-indol-1-yl]-2-methyl-3,11a-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-dione. Grades: ≥98% by HPLC. CAS No. 1403-36-7. Molecular formula: C31H30N6O6S4. Mole weight: 710.87. BOC Sciences 5

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