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| Product | Description | |
|---|---|---|
| CHIR-99021 | A potent and highly selective inhibitor of glycogen synthase kinase-3beta (GSK-3b) (IC50 = 6.7nM). CHIR99021 has been shown to allow for long-term expansion of murine embryonic stem cells in a chemically-defined medium in conjunction with MEK/MAPK inhibitor PD184352 and fibroblast growth factor receptor (FGFR) inhibitor SU5402. Group: Biochemicals. Alternative Names: 6-((2-((4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2- yl) pyrimidin-2-yl) amino) ethyl) amino) nicotinonitrile; CT99021; CHIR 911. Grades: Highly Purified. CAS No. 252917-06-9. Pack Sizes: 5mg. US Biological Life Sciences. |  Worldwide |
| CHIR-99021 | CHIR-99021 (CT99021) is a glycogen synthase kinase 3β (GSK3β) inhibitor that has antiproliferative activity in vitro and in vivo. It enhances reprogramming of mouse embryonic fibroblasts, transduced by Oct4 and Klf4 only, into iPSCs in combination with tranylcypromine. It also induces cardiomyocyte differentiation from human embryonic stem (ES). Uses: Potential antineoplastic agent. Synonyms: CHIR-99021; CT99021; 6-[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl]amino]ethylamino]pyridine-3-carbonitrile. Grades: >98%. CAS No. 252917-06-9. Molecular formula: C22H18Cl2N8. Mole weight: 465.342. |  |
| CHIR-99021 Hydrochloride | CHIR-99021 is a potent and highly selective inhibitor of glycogen synthase kinase 3 (GSK-3). CHIR-99021 activates glycogen synthesis in CHO-IR cells and in isolated type 1 diabetic rat skeletal muscle. CHIR-99021 has also been shown to induce the reprogramming of murine and human somatic cells into stem cells. Group: Biochemicals. Alternative Names: 6- [ [2- [ [4- (2, 4-Dichlorophenyl) -5- (5-methyl-1H-imidazol-2-yl) -2-pyrimidinyl] amino] ethyl] amino] -3-pyridinecarbonitrile Hydrochloride; CHIR 911 Hydrochloride; CT 99021 Hydrochloride. Grades: Highly Purified. CAS No. 1797989-42-4. Pack Sizes: 10mg. Molecular Formula: C22H19Cl3N8, Molecular Weight: 501.8. US Biological Life Sciences. | Worldwide |
| CHIR 99021 dihydrochloride | CHIR 99021 is a potent glycogen synthase kinase GSK-3 inhibitor. Synonyms: CHIR-99021 dihydrochloride; CHIR99021 dihydrochloride; CT-99021 dihydrochloride; CT 99021 dihydrochloride; CT99021 dihydrochloride; GSK-3 Inhibitor XVI dihydrochloride; 6-[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl]amino]ethylamino]pyridine-3-carbonitrile dihydrochloride. Grades: 99%. CAS No. 2109414-84-6. Molecular formula: C22H18Cl2N8.2HCl. Mole weight: 538.26. | |
| CHIR99021 HCl | CHIR99021, also known as CT99021, is a GSK-3α/β inhibitor (IC50= 10 nM/6.7 nM) with antiproliferative activity in vitro and in vivo. CHIR-99021 has also been shown to induce the reprogramming of murine and human somatic cells into stem cells. Synonyms: 6-((2-((4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile hydrochloride; CHIR99021 HCl; CHIR99021 hydrochloride; CHIR99021; CHIR-99021; CHIR 99021; CT99021; CT-99021; CT 99021. CAS No. 1797989-42-4. Molecular formula: C22H19Cl3N8. Mole weight: 501.8. | |
| CHIR 99021 trihydrochloride | CHIR 99021 is a highly selective GSK-3 inhibitor. CHIR 99021 is used in the treatment of parkinsonism. Uses: The treatment of parkinsonism. Synonyms: CHIR-99021 trihydrochloride; CHIR 99021 trihydrochloride; CHIR99021 trihydrochloride; 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile trihydrochloride. Grades: ≥98% by HPLC. CAS No. 1782235-14-6. Molecular formula: C22H18Cl2N8.3HCl. Mole weight: 574.72. | |
| Laduviglusib | Laduviglusib (CHIR-99021) is a potent, selective and orally active GSK-3?/? inhibitor with IC50s of 10 nM and 6.7 nM. Laduviglusib shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib is also a potent Wnt/?-catenin signaling pathway activator. Laduviglusib enhances mouse and human embryonic stem cells self-renewal. Laduviglusib induces autophagy[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CHIR-99021; CT99021. CAS No. 252917-06-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10182. |  |
| Laduviglusib monohydrochloride | Laduviglusib (CHIR-99021) monohydrochloride is a potent and selective GSK-3?/? inhibitor with IC50s of 10 nM and 6.7 nM. Laduviglusib monohydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib monohydrochloride is also a potent Wnt/?-catenin signaling pathway activator. Laduviglusib monohydrochloride enhances mouse and human embryonic stem cells self-renewal. Laduviglusib monohydrochloride induces autophagy[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CHIR-99021 monohydrochloride; CT99021 monohydrochloride. CAS No. 1797989-42-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10182A. | |
| Laduviglusib (Standard) | Laduviglusib (Standard) is the analytical standard of Laduviglusib. Laduviglusib (CHIR-99021) is a potent, selective and orally active GSK-3α/β inhibitor with IC 50 s of 10 nM and 6.7 nM. Laduviglusib shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib is also a potent Wnt/β-catenin signaling pathway activator. Laduviglusib enhances mouse and human embryonic stem cells self-renewal. Laduviglusib induces autophagy [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CHIR-99021 (Standard); CT99021 (Standard). CAS No. 252917-06-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-10182R. | |
| Laduviglusib trihydrochloride | Laduviglusib (CHIR-99021) trihydrochloride is a potent and selective GSK-3?/? inhibitor with IC50s of 10 nM and 6.7 nM. Laduviglusib trihydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib trihydrochloride is also a potent Wnt/?-catenin signaling pathway activator. Laduviglusib trihydrochloride enhances mouse and human embryonic stem cells self-renewal. Laduviglusib trihydrochloride induces autophagy[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CHIR-99021 trihydrochloride; CT99021 trihydrochloride. CAS No. 1782235-14-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10182B. | |
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