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| Product | Description | |
|---|---|---|
| Cholesterol Dehydrogenase from Nocardia sp. | Cholesterol dehydrogenase is an enzyme that uses nicotinamide adenine dinucleotide/nicotinamide adenine dinucleotide phosphate (NAD(P)) as its cofactor in oxidizing cholesterol to form cholest-4-en-3-one. This enzyme oxidizes the hydroxyl group at the 3 position of the sterol ring to form a ketone. Group: Enzymes. Synonyms: Cholesterol Dehydrogenase; CDH. CAS No. 67775-34-2. Activity: 10U/mg-solid or more. Storage: at -20°C. Form: Freeze dried powder. Source: Nocardia sp. Cholesterol Dehydrogenase; CDH. Cat No: NATE-0892. |  |
| Native Nocardia sp. Cholesterol Dehydrogenase | Cholesterol dehydrogenase is an enzyme that uses nicotinamide adenine dinucleotide/nicotinamide adenine dinucleotide phosphate (NAD(P)) as its cofactor in oxidizing cholesterol to form cholest-4-en-3-one. This enzyme oxidizes the hydroxyl group at the 3 position of the sterol ring to form a ketone. Applications: Used in the formulation of cholesterol testing reagents or in biosensor applications. Group: Enzymes. Synonyms: Cholesterol Dehydrogenase; CDH. CDH. Mole weight: 37 kDa (SDS-PAGE). Activity: > 5 U/mg. Appearance: Light yellow to brown powder. Form: Freeze dried powder. Source: Nocardia sp. Cholesterol Dehydrogenase; CDH. Cat No: NATE-0892. | |
| 2-Cyclopropylethanol | 2-Cyclopropylethanol is used as a reagent to synthesize 22-Hydroxycholesterol (H918010) derivatives, compounds that act as serum cholesterol lowering agents. 2-Bromoethylcyclopropane is also used to prepare pyridazinones, 2-Cyclopropylethanol is also used to synthesize potent 15-Hydroxyprostaglandin dehydrogenase inhibitors, which ultimately minimize excessive scarring of wounds. Group: Biochemicals. Grades: Highly Purified. CAS No. 2566-44-1. Pack Sizes: 2.5g, 5g. Molecular Formula: C5H10O, Molecular Weight: 86.13. US Biological Life Sciences. |  Worldwide |
| 3α,7α,12α-trihydroxy-5β-cholest-24-enoyl-CoA hydratase | This enzyme forms part of the rat peroxisomal multifunctional enzyme perMFE-2, which also exhibits a dehydrogenase activity. The enzyme is involved in the β-oxidation of the cholesterol side chain in the cholic-acid-biosynthesis pathway. Group: Enzymes. Synonyms: 46 kDa hydratase 2; (24R,25R)-3α,7α,12α,24-tetrahydroxy-5β-cholestanoyl-CoA hydro-lyase. Enzyme Commission Number: EC 4.2.1.107. CAS No. 152787-68-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4946; 3α,7α,12α-trihydroxy-5β-cholest-24-enoyl-CoA hydratase; EC 4.2.1.107; 152787-68-3; 46 kDa hydratase 2; (24R,25R)-3α,7α,12α,24-tetrahydroxy-5β-cholestanoyl-CoA hydro-lyase. Cat No: EXWM-4946. | |
| 3β-hydroxysteroid 3-dehydrogenase | The enzyme acts on multiple 3β-hydroxysteroids. Participates in the biosynthesis of zemosterol and cholesterol, where it catalyses the reaction in the opposite direction to that shown. The mammalian enzyme is bifunctional and also catalyses EC 1.1.1.62, 17β-estradiol 17-dehydrogenase. Group: Enzymes. Synonyms: 3-keto-steroid reductase; 3-KSR; HSD17B7 (gene name); ERG27 (gene name). Enzyme Commission Number: EC 1.1.1.270. CAS No. 42616-29-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0177; 3β-hydroxysteroid 3-dehydrogenase; EC 1.1.1.270; 42616-29-5; 3-keto-steroid reductase; 3-KSR; HSD17B7 (gene name); ERG27 (gene name). Cat No: EXWM-0177. | |
| 3β-hydroxysteroid-4α-carboxylate 3-dehydrogenase (decarboxylating) | The enzyme catalyses the decarboxylation of the C-4 carbon and the dehydrogenation of a 3β hydroxyl at the C-3 carbon of 3β-hydroxysteroid-4α-carboxylates. It is involved in zymosterol and cholesterol biosynthesis. Group: Enzymes. Synonyms: 3β-hydroxy-4β-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating); 3β-hydroxy-4β-methylcholestenoate dehydrogenase; sterol 4α-carboxylic decarboxylase; sterol-4α-carboxylate 3-dehydrogenase (decarboxylating) (ambiguous); ERG26 (gene name); NSDHL (gene name). Enzyme Commission Number: EC 1.1.1.170. CAS No. 71822-23-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0074; 3β-hydroxysteroid-4α-carboxylate 3-dehydrogenase (decarboxylating); EC 1.1.1.170; 71822-23-6; 3β-hydroxy-4β-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating); 3β-hydroxy-4β-methylcholestenoate dehydrogenase; sterol 4α-carboxylic decarboxylase; sterol-4α-carboxylate 3-dehydrogenase (decarboxylating) (ambiguous); ERG26 (gene name); NSDHL (gene name). Cat No: EXWM-0074. | |
| 5α-Cholestan-3 β-ol | 5α-Cholestan-3 β-ol is a carbon stanol formed from biohydrogenation of Cholesterol (C432501) in the gut. Studies have also examined the conversion of 5α-Cholestan-3 β-ol catalyzed by 3- β-hydroxysteroid dehydrogenase of rat liver. Group: Biochemicals. Alternative Names: (3 β,5α)-Cholestan-3-ol; 3 β-Hydroxy-5α-cholestane; 3 β-Hydroxycholestane; 5α(H)-Cholestan-3 β-ol; 5α-Cholestanol; 5α-Dihydrocholesterol; Cholestan-3 β-ol; Cholestanol; Dihydrocholesterin; Dihydrocholesterol; Dihydrolathosterol; Lathostanol; NSC 18188; Zymostanol; β-Cholestanol. Grades: Highly Purified. CAS No. 80-97-7. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| 5β,6β-epoxycholestanol | 5β,6β-epoxycholestanol is an oxidative metabolite of cholesterol formed by free-radical and non-radical oxidation of cholesterol at the 5,6 double bond. Induces lactate dehydrogenase (LDH) release and apoptosis in macrophage-differentiated U937 cells. Cholesterol 5beta,6beta-epoxide has been found in human fatty streaks and advanced atherosclerotic lesions, but not in normal aortic tissue [1] [2] [3]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: Cholesterol 5beta,6beta-epoxide. CAS No. 4025-59-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-130502. |  |
| 7-dehydrocholesterol reductase | The enzyme is part of the cholesterol biosynthesis pathway. Group: Enzymes. Synonyms: DHCR7 (gene name); 7-DHC reductase; 7-dehydrocholesterol dehydrogenase/cholesterol oxidase; Δ7-sterol reductase. Enzyme Commission Number: EC 1.3.1.21. CAS No. 9080-21-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1296; 7-dehydrocholesterol reductase; EC 1.3.1.21; 9080-21-1; DHCR7 (gene name); 7-DHC reductase; 7-dehydrocholesterol dehydrogenase/cholesterol oxidase; Δ7-sterol reductase. Cat No: EXWM-1296. | |
| β-Nicotinamide-Adenine Dinucleotide Phosphate, Oxidized Form (β-NADP-K) | β-Nicotinamide adenine dinucleotide 2?-phosphate (NADP+) and β-Nicotinamide adenine dinucleotide 2?-phosphate, reduced (NADPH) comprise a coenzyme redox pair (NADP+:NADPH) involved in a wide range of enzyme catalyzed oxidation reduction reactions. The NADP+/NADPH redox pair facilitates electron transfer in anabolic reactions such as lipid and cholesterol biosynthesis and fatty acyl chain elongation. The NADP+/NADPH redox pair is used in a variety of antioxidation mechanism where it protects agains reactive oxidation species accumulation. NADPH is generated in vivio by the pentose phosphate pathway (PPP). Group: Coenzymes. Synonyms: β-Nicotinamide-Adenine Dinucleotide Phosphate, Oxidized Form (β-NADP-K); β-Nicotinamide-Adenine Dinucleotide Phosphate;. CAS No. 698999-85-8. Purity: Determined by increase in absorbance at 340nm on enzymatic reduction with G6PDH* at pH 10 (More than 95%) *G6PDH = Glucose-6-phosphate dehydrogenase (yeast) (EC 1.1.1.49.). β-NADP-K. Mole weight: 781.5. Storage: Keep tightly stoppered in the dark below 5°C. Moisture will reduce the purity. For prolonged storage, keep below-20°C. β-Nicotinamide-Adenine Dinucleotide Phosphate, Oxidized Form (β-NADP-K); β-Nicotinamide-Adenine Dinucleotide Phosphate; β-NADP-K. Cat No: NATE-0788. | |
| Leelamine hydrochloride | Leelamine is a diterpene amine exhibiting low affinity for the human central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. It also acts as an inhibitor of pyruvate dehydrogenase kinase (PDK). Leelamine inhibits intracellular cholesterol transport and suppresses cancer cell growth. Synonyms: Lylamine hydrochloride; Dehydroabiethylamine hydrochloride; [(1R,4aS,10aR)-1,4a-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthren-1-yl]methanamine hydrochloride. Grades: ≥98%. CAS No. 16496-99-4. Molecular formula: C20H31N·HCl. Mole weight: 321.9. |  |
| Native Bacillus sphaericus 12α-Hydroxysteroid Dehydrogenase | In enzymology, a 12alpha-hydroxysteroid dehydrogenase (EC 1.1.1.176) is an enzyme that catalyzes the chemical reaction:3alpha,7alpha,12alpha-trihydroxy-5beta-cholanate + NADP+<-> 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + NADPH + H+. Thus, the two substrates of this enzyme are 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanate and NADP+, whereas its 3 products are 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate, NADPH, and H+. This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. This enzyme is involved in a metabolic pathway that degrades bile acids into cholesterol. Group: Enzymes. Synonyms: EC 1.1.1.176; 61642-40-8; 12α Hydroxysteroid Dehydrogenase; 12alpha-hydroxy steroid dehydrogenase; NAD+-dependent. Enzyme Commission Number: EC 1.1.1.176. CAS No. 61642-40-8. 12α-Hydroxysteroid Dehydrogenase. Activity: 150-350 units/mg protein (Lowry). Storage: -20°C. Form: lyophilized powder. Source: Bacillus sphaericus. EC 1.1.1.176; 61642-40-8; 12α Hydroxysteroid Dehydrogenase; 12alpha-hydroxy steroid dehydrogenase; NAD+-dependent 12alpha-hydroxysteroid dehydrogenase; NADP+-12alpha-hydroxysteroid dehydrogenase; 12-α-Hydroxysteroid Dehydrogenase; 12alpha-hydroxysteroid:NADP+ 12-oxidoreductase. Cat No: NATE-0001. | |
| Sesamin | A lignan isolated from the bark of Fagara plants and from sesame oil. Studies show that it has has multiple functions such as cholesterol-lowering and anti-hypertensive activities. It induces the expression of the gene for aldehyde dehydrogenase, an alcohol-metabolizing enzyme suggesting it regulates the metabolism of lipids, xenobiotics, and alcohol at the mRNA level. Group: Biochemicals. Alternative Names: (1S,3aR,4S,6aR)-5,5'-(Tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl)bis-1,3-benzodioxole; (+)-Sesamin; ; Fagarol; NSC 36403; Sesamin; Sezamin; d-Sesamin; 5,5'-(Tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl)bis-1,3-benzodioxole; [1S-(1α, 3aα, 4α, 6aα)]-5, 5'-(Tetrahydro-1H, 3H-furo[3, 4-c]furan-1, 4-diyl)bis-1, 3-benzodioxole; Tetrahydro-1, 4-bis[3, 4- (methylenedioxy) phenyl]-1H, 3H-furo[3, 4-c]furan; (1S, 3aR, 4S, 6aR) -Tetrahydro-1, 4-bis[3, 4- (methylenedioxy) phenyl]-1H, 3H-Furo[3, 4-c]furan. Grades: Highly Purified. CAS No. 607-80-7. Pack Sizes: 500mg. US Biological Life Sciences. | Worldwide |
| steroid Δ-isomerase | This activity is catalysed by several distinct enzymes (cf. EC 1.1.3.6, cholesterol oxidase and EC 1.1.1.145, 3-hydroxy-5-steroid dehydrogenase). Group: Enzymes. Synonyms: hydroxysteroid isomerase; steroid isomerase; Δ5-ketosteroid isomerase; Δ5(or Δ4)-3-keto steroid isomerase; Δ5-steroid isomerase; 3-oxosteroid isomerase; Δ5-3-keto steroid isomerase; Δ5-3-oxosteroid isomerase. Enzyme Commission Number: EC 5.3.3.1. CAS No. 9031-36-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5489; steroid Δ-isomerase; EC 5.3.3.1; 9031-36-1; hydroxysteroid isomerase; steroid isomerase; Δ5-ketosteroid isomerase; Δ5(or Δ4)-3-keto steroid isomerase; Δ5-steroid isomerase; 3-oxosteroid isomerase; Δ5-3-keto steroid isomerase; Δ5-3-oxosteroid isomerase. Cat No: EXWM-5489. | |
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