Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
| Product | Description | |
|---|---|---|
| CHR-6494 | CHR-6494, a histone kinase Haspin inhibitor, has been found to have wide spectrum anticancer effect and prabably influence the mitotic kinase at some extent. Uses: Chr-6494 is a histone kinase haspin inhibitor that has been found to have wide spectrum anticancer effect and prabably influence the mitotic kinase at some extent. Synonyms: CHR-6494; CHR 6494; CHR6494;1333377-65-3;3-(1H-indazol-5-yl)-N-propylimidazo[1,2-b]pyridazin-6-amine;QCR-8;C16H16N6;3199AH. Grades: 95%. CAS No. 1333377-65-3. Molecular formula: C16H16N6. Mole weight: 292.34. |  |
| CHR-6494 trifluoroacetate salt | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| Haspin Kinase Inhibitor, CHR-6494 (3-(1H-Indazol-5-yl)-N-propylimidazo[1,2-b]pyridazin-6-amine, Haploid Germ Cell-Specific Nuclear Protein Kinase Inhibitor, CHR-6494, Indazolyl-propylimidazopyridazin-amine) | A cell-permeable indazolyl imidazopyridazinamine compound that acts as a potent and reversible inhibitor of histone kinase haspin activity (IC50 = 2nM) with moderate selectivity over TrkA, GSK-3beta, PIM1, Cdk1/B and Cdk2/A (% inhibition at 100nM = 58, 48, 36, 34 and 33, respectively) among a panel of 27-kinases. Shown to block pH3-Thr3, with no effect on pH3-Ser10 and pH3-Ser28, cause mitotic catastrophe, upregulate BUB1 and cyclin B1 levels, and potently induce apoptosis (IC50 = 473, 500 and 752nM in HeLa, HCT-116 and MDA-MB-231 cells, respectively). Further, efficiently blocks bFGF-induced sprouting vessel by 70% at 1uM (chicken embryo aortic arch ring assay) and suppresses tumor growth in HCT-116 xenografted mouse model (50mg/kg, i.p.). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| CHR 6494 trifluoroacetate | The trifluoroacetate salt form of CHR 6494, which is a potent haspin kinase inhibitor and exhibits a wide spectrum of anticancer effects. Synonyms: CHR 6494 trifluoroacetate; CHR6494 trifluoroacetate; CHR-6494 trifluoroacetate; 3-(1H-Indazol-5-yl)-N-propylimidazo[1,2-b]pyridazin-6-amine trifluoroacetate. Grades: ≥98% by HPLC. CAS No. 1458630-17-5. Molecular formula: C16H16N6.CF3CO2H. Mole weight: 406.36. | |
Our database is helping our users find suppliers everyday.
