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| Product | Description | |
|---|---|---|
| CHS-828 | Antitumor compound. Programmed cell death inducer. Cytotoxic. Antiproliferative. p53 activator. IkappaB kinase inhibitor. NF-kappaB inhibitor. Nampt/visfatin inhibitor. Group: Biochemicals. Alternative Names: GMX1778, (E)-1--2-cyano-3-(pyridin-4-yl)guanidine. Grades: Highly Purified. CAS No. 200484-11-3. Pack Sizes: 5mg, 25mg. Molecular Formula: C19H22ClN5O. US Biological Life Sciences. |  Worldwide |
| CHS-828 | CHS-828 is a synthetic guanidine-based small anticancer molecule. CHS 828 was found to exert potent cytotoxic effects in human breast and lung cancer cell lines, with lesser effects on normal fibroblasts and endothelial cells. In nude mice bearing human tumor xenografts, CHS 828, at doses from 20 to 50 mg/kg/day p.o., inhibited the growth of MCF-7 breast cancer tumors and caused regression of NYH small cell lung cancer tumors. Oral administration of CHS 828 once weekly improved efficacy without increasing toxicity. CHS 828 was found to compare favorably with established chemotherapeutic agents such as cyclophosphamide, etoposide, methotrexate, and paclitaxel. In mice with NYH tumors, long-term survival (>6 months) was observed after treatment with CHS 828 was stopped. CHS 828 is an effective new antitumor agent, with a potentially new mechanism of action. CHS-828 appeared to kill cancer cells by depleting NAD. CHS 828 is presently being tested in Phase I clinical trials in collaboration with the European Organization for Research and Treatment of Cancer. Synonyms: CHS 828; CHS828; CHS-828; GMX-1778; GMX1778; GMX 1778. CAS No. 200484-11-3. Molecular formula: C19H22ClN5O. Mole weight: 371.869. |  |
| CHS-828 (GMX1778, (E)-1-[6-(4-Chlorophenoxy)hexyl]-2-cyano-3-(pyridin-4-yl)guanidine) | A pyridyl cyanoguanidine derivative that displays potent antitumor activity. Also acts as an inhibitor of Nampt/visfatin, NF-kB and IkB kinase. In addition, CHS-828 induces programmed cell death and activates p53. Group: Biochemicals. Grades: Highly Purified. CAS No. 200484-11-3. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. | Worldwide |
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