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| Product | Description | |
|---|---|---|
| chymase | In mast cell granules. In peptidase family S1 (trypsin family). Group: Enzymes. Synonyms: mast cell protease I; skeletal muscle protease; skin chymotryptic proteinase; mast cell serine proteinase, chymase; skeletal muscle (SK) protease. Enzyme Commission Number: EC 3.4.21.39. CAS No. 97501-92-3. CMA1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4133; chymase; EC 3.4.21.39; 97501-92-3; mast cell protease I; skeletal muscle protease; skin chymotryptic proteinase; mast cell serine proteinase, chymase; skeletal muscle (SK) protease. Cat No: EXWM-4133. |  |
| Chymase from Human, Recombinant | Chymases are a family of serine proteases found primarily in mast cells, though also present in basophil granulocytes (e.g. alpha chymase mcpt8). They show broad peptidolytic activity and are involved in a variety of functions. For example, chymases are released by mucosal mast cells upon challenge with parasites and parasite antigens promoting an inflammatory response. Chymases are also known to convert angiotensin I to angiotensin II and thus play a role in hypertension and atherosclerosis. Because of its role in inflammation it has been investigated as a target in the treatment of asthma. Applications: Chymase has been implicated in generation of angiotensin ii and cleavag... Synonyms: mast cell protease I; skeletal muscle protease; skin chymotryptic proteinase; mast cell serine proteinase, chymase; skeletal muscle (SK) protease; chymase; EC 3.4.21.39; 97501-92-3. Enzyme Commission Number: EC 3.4.21.39. CAS No. 97501-92-3. Purity: >90% (SDS-PAGE). CMA1. Mole weight: ~30 kDa. Activity: >40 units/mg protein. Storage: Store at -20°C. Form: Supplied as a solution in 20 mM Tris, 0.8 M NaCl and 25% glycerol, pH 7.6. Source: Pichia pastoris. Species: Human. mast cell protease I; skeletal muscle protease; skin chymotryptic proteinase; mast cell serine proteinase, chymase; skeletal muscle (SK) protease; chymase; EC 3.4.21.39; 97501-92-3. Cat No: NATE-0817. | |
| Chymase human | recombinant, expressed in Pichia pastoris. Group: Fluorescence/luminescence spectroscopy. |  |
| BAY-1142524 | BAY-1142524 is a chymase inhibitor. Chymase is an enzyme that modulates the production of proteins playing a role in adverse cardiac tissue remodeling and fibrogenesis. Study shows that BAY-1142524 could suppress the abnormal cardiac tissue remodeling after myocardial infarction (MI) and improves cardiac function. Uses: Abnormal cardiac tissue remodeling reduction. Synonyms: BAY-1142524; BAY 1142524; BAY1142524. |  |
| CH 5450 | Z-Ile-Glu-Pro-Phe-Ome is a peptide inhibitor of human heart chymase which is a chymotrypsin-like enzyme that converts angiotensin I to angiotensin II. Synonyms: ZIEPF-Ome; N-benzyloxycarbonyl-L-isoleucyl-L-alpha-glutamyl-L-prolyl-L-phenylalanine methyl ester; Cbz-Ile-Glu-Pro-Phe-OMe; CH5450; CH-5450. Grades: ≥95%. CAS No. 252557-97-4. Molecular formula: C34H44N4O9. Mole weight: 652.73. | |
| Chymostatin | Chymostatin is a bioactive peptide that acts as a protease inhibitor with selectivity for chymotryptase-like serine proteases. It potently inhibits chymotrypsin and chymase, but it cannot block the activity of cathepsins, papain, and leukocyte elastase effectively. It doesn't have effect on trypsin, thrombin, plasmin, pepsin, and kallikrein. Uses: Serine proteinase inhibitors. Synonyms: [(S)-1-Carboxy-2-phenylethyl]-carbamoyl-a-[2-amidohexahydro-4(S)-pyrimidyl]-(S)-glycyl-[A= Leu B=Val C=Ile]-phenylalaninal (Mixture). Grades: ≥95% (a mixture of A, B, C). CAS No. 9076-44-2. Molecular formula: CxHyN7O6. Mole weight: 607.7. | |
| Fulacimstat | Fulacimstat is a chymase inhibitor with IC50 of 4 nM and 3 nM for human and hamster chymase enzyme, respectively. Uses: Enzyme inhibitors. Synonyms: BAY1142524. CAS No. 1488354-15-9. Molecular formula: C23H16F3N3O6. Mole weight: 487.4. | |
| Fulacimstat | Fulacimstat is an orally available chymase inhibitor, with IC 50 s of 4, 3 nM for human and hamster chymase enzyme, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BAY1142524. CAS No. 1488354-15-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109059. |  |
| JNJ10311795 | JNJ10311795 is a dual inhibitor of Chymase and leukocyte Proteases Cathepsin G. It has inflammation therapeutic efficacy in animals models. Uses: Jnj10311795 has inflammation therapeutic efficacy. Synonyms: JNJ-10311795; JNJ 10311795; JNJ10311795. [2-[3-[Methyl-[1-(naphthalene-2-carbonyl)piperidin-4-yl]carbamoyl]naphthalen-2-yl]-1-naphthalen-1-yl-2-oxoethyl]phosphonic acid;Phosphonic acid, (2-(3-((methyl(1-(2-naphthalenylcarbonyl)-4-piperidinyl)amino)carbonyl)-2-naphthalenyl)-1-(1-naph. Grades: 98%. CAS No. 518062-14-1. Molecular formula: C40H35N2O6P. Mole weight: 670.70. | |
| N-[2-[4- (Aminosulfonyl) phenyl]ethyl]carbamic Acid tert-Butyl Ester | Used in the preparation of diazepane compounds as chymase inhibitors for treatement of bronchial asthma and urticaria. Group: Biochemicals. Alternative Names: N-[2-[4- (Aminosulfonyl) phenyl]ethyl]-carbamic Acid 1,1-Dimethylethyl Ester; (4-Sulfamoylphenethyl) carbamic Acid tert-Butyl Ester. Grades: Highly Purified. CAS No. 258262-54-3. Pack Sizes: 250mg. US Biological Life Sciences. |  Worldwide |
| RETF-4NA | RETF-4NA is a sensitive substrate for chymase when free or bound to α2M. It is selectively hydrolyzed by chymase but not by cathepsin G. Synonyms: acetyl-L-Arg-Glu-Thr-Phe-4-nitroanilide. CAS No. 1160928-63-1. Molecular formula: C32H43N9O10. Mole weight: 713.75. | |
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