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| Product | Description | |
|---|---|---|
| CI-1040 | CI-1040 is a MEK inhibitor, which demonstrated in vivo activity in preclinical animal models and subsequently became the first MEK inhibitor to enter clinical trial. CI-1040 suffered however from poor exposure due to its poor solubility and rapid clearance, and as a result, development of the compound was terminated. Synonyms: CI1040; CI-1040; CI 1040; PD184352; PD 184352; PD-184352. CAS No. 212631-79-3. Molecular formula: C17H14ClF2IN2O2. Mole weight: 478.662. |  |
| CI-1040 | CI-1040 (PD 184352) is an orally active, highly specific, small-molecule inhibitor of MEK with an IC 50 of 17 nM for MEK1. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PD 184352. CAS No. 212631-79-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-50295. |  |
| PD 184,352 (2-(2-Chloro-4-iodo-phenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide, CI-1040) | MEK (MAPKK) inhibitor. Potent and selective MAPK (ERK kinase 1; MEK1) activation inhibitor (IC50 = 300 nM in vitro, IC50 = 2 nM in vivo). Suppresses activation of MAPK but does not block its activity. Antiproliferative. Causes cell-cycle arrest in G1 phase. Tumor suppressor. Apoptosis inducer. Group: Biochemicals. Alternative Names: 2-(2-Chloro-4-iodo-phenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide, CI-1040. Grades: Highly Purified. CAS No. 212631-79-3. Pack Sizes: 1mg, 5mg. Molecular Formula: C17H14ClF2IN2O2, Molecular Weight: 478.7. US Biological Life Sciences. |  Worldwide |
| PD0325901 | PD-0325901 is a potent bioavailable and selective MEK inhibitor, which targets mitogen-activated protein kinase kinase (MAPK/ERK kinase or MEK) with potential antineoplastic activity. MEK inhibitor PD325901, a derivative of MEK inhibitor CI-1040, selectively binds to and inhibits MEK, which may result in the inhibition of the phosphorylation and activation of MAPK/ERK and the inhibition of tumor cell proliferation. The dual specific threonine/tyrosine kinase MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that is frequently activated in human tumors. Uses: Reprogramming, self-renewal. Synonyms: PD 0325901; PD 325901. Grades: >98%. CAS No. 391210-10-9. Molecular formula: C16H14F3IN2O4. Mole weight: 482.198. | |
| PD-325901, Free Base (PD 0325901, MEK1/2 Inhibitor III) | A selective and ATP non-competitive MEK inhibitor that suppresses the phosphorylation of ERK in murine colon 26 tumors (IC50 = 0.33nM). In combination with the GSK-3 inhibitor CHIR99021, prevents cell differentiation and sustains self-renewal of embryonic stem (ES) cells. PD 325901 is an inhibitor of mitogen activated protein kinase kinase (MEK or MAPKK). The potency, solubility and effectiveness of PD 325901 are greatly improved compared to PD 184352 (CI-1040). Group: Biochemicals. Alternative Names: N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2[(2-fluoro-4-iodophenyl)amino]-benzamide; PD 0325901, MEK1/2 Inhibitor III. Grades: Highly Purified. CAS No. 391210-10-9. Pack Sizes: 10mg, 25mg. US Biological Life Sciences. | Worldwide |
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