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| Product | Description | |
|---|---|---|
| CID 1067700 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| CID 1067700 | CID 1067700 is a Rab7 GTPase inhibitor exhibiting significant inhibitory potency against Rab7 nucleotide binding with nanomolar inhibitor (Ki) values and an inhibitory response of ≥97% for BODIPY-GTP and BODIPYGDP binding (Ki values 13 nM and 19 nM, and EC50 values 11 and 21 nM, respectively). CID 1067700 is a competitive guanine nucleotide binding inhibitor. Synonyms: CID 1067700; CID1067700; 2-(3-benzoylthioureido)-5,5-dimethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxylic acid; MLS000673908; ML282; SMR000297947; CID-1067700. Grades: 99%. CAS No. 314042-01-8. Molecular formula: C18H18N2O4S2. Mole weight: 390.48. |  |
| Ras Superfamily GTPases GTP/GDP Binding Antagonist, CID 1067700 | A thiourea-derived small molecule that acts as a competitive inhibitor of nucleotide (BODIPY-GTP and BODIPY-GDP) binding by Rab7 (Ki=12.89-19.70nM). Equilibrates rapidly with Rab7 without affecting the rate of release of bound BODIPY-GTP or BODIPY-GDP. However, it exhibits a slightly lower potency against BODIPY-GDP bound Rab7 than BODIPY-GTP bound Rab7A. Acts by binding to the nucleotide binding pocket of Rab7. Also shown to inhibit nucleotide binding by mutant forms of Rab7 (Rab7Q67L and Rab7T22N) that are constitutively in the GTP and GDP bound states, with good potency. Also shown to block the nucleotide binding of several other Ras-related GTPases, but with reduced potency. Group: Biochemicals. Grades: Highly Purified. CAS No. 314042-01-8. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?S?, Primary Target: Rab7. US Biological Life Sciences. |  Worldwide |
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