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Product | Description | |
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Cilastatin Quick inquiry Where to buy Suppliers range | Prevents renal metabolism of penem and carbapenem antibiotics by specific and reversible dehydropeptidase I inhibition. Antibacterial adjunct.Cilastatin is an inhibitor of dipeptidase (dehydropeptidase I), a renal dipeptidase.1 It inhibits human renal dipeptidase (Ki = 0.7uM), porcine dipeptidase (IC50 = 0.11uM), and bacterial metallo- β-lactamase CphA from A. hydrophila (IC50 = 178uM).1,2,3 Cilastatin (200ug/ml) protects primary porcine renal proximal tubular epithelial cells from nephrotoxicity and apoptosis induced by vancomycin.4 In a mouse model of systemic infection, cilastatin in combination with imipenem protects mice from S. aureus, E. coli, and P. aeruginosa infection.5 Cilastatin was designed to inhibit renal metabolism of imipenem and prolong its half-life.2 Formulations containing cilastatin in combination with imipenem have been used to treat susceptible bacterial infections. Group: Biochemicals. Alternative Names: (2Z) -7- [ [ (2R) -2-amino-2-carboxyethyl] thio] -2- [ [ [ (1S) -2, 2-dimethylcyclopropyl] carbonyl] amino] -2-heptenoic Acid; MK-791. Grades: Highly Purified. CAS No. 82009-34-5. Pack Sizes: 10mg, 25mg, 50mg, 100mg. Molecular Formula: C??H??N?O?S, Molecular Weight: 358.45. US Biological Life Sciences. | Worldwide |
Cilastatin Quick inquiry Where to buy Suppliers range | Cilastatin. Uses: For analytical and research use. Group: Chiral Molecules. Alternative Names: 2-Heptenoic acid, 7-[(2-amino-2-carboxyethyl)thio]-2-[[(2,2-dimethylcyclopropyl)carbonyl]amino]-, [R-[R*,S*-(Z)]]-, (2Z)-7-[[(2R)-2-Amino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-2-heptenoic acid, Cilastatin, Cilastin,2-Heptenoic acid, 7-[[(2R)-2-amino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-, (2Z)-. CAS No. 82009-34-5. Pack Sizes: 10MG. IUPAC Name: (Z) -7- [ (2R) -2-amino-2-carboxyethyl] sulfanyl-2- [ [ (1S) -2, 2-dimethylcyclopropanecarbonyl] amino] hept-2-enoic acid. Molecular formula: C16H26N2O5S. Mole weight: 358.45. Catalog: APS82009345. SMILES: CC1 (C)C[C@@H]1C (=O)N\C (=C/CCCCSC[C@H] (N)C (=O)O)\C (=O)O. Format: Neat. Shipping: Room Temperature. | |
Cilastatin Quick inquiry Where to buy Suppliers range | Cilastatin can prevent renal metabolism of penem and carbapenem antibiotics by specific and reversible dehydropeptidase I inhibition. It can be used as antibacterial adjunct. Uses: Antibacterial adjunct. Synonyms: (2Z)-7-[[(2R)-2-amino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-2-heptenoic Acid;MK-791; MK 791; MK791. Grades: >95%. CAS No. 82009-34-5. Molecular formula: C16H26N2O5S. Mole weight: 358.45. | |
Cilastatin Ammonium Salt Quick inquiry Where to buy Suppliers range | Cilastatin Ammonium Salt. Uses: For analytical and research use. Group: Chiral Molecules. Pack Sizes: 10MG. Catalog: APS006761. Format: Neat. Shipping: Room Temperature. | |
Cilastatin Ammonium Salt Quick inquiry Where to buy Suppliers range | Cilastatin Ammonium Salt is the ammonium salt of Cilastatin, which is a dipeptidase inhibitor of renal enzyme dehydropeptidase-I and leukotriene D4 peptidase. It inhibits metabolism of LTD4 to LTE4 and the hydrolysis of β-lactam antibiotics. It reduces toxic accumulation of cyclosporin A in kidney proximal tubule epithelial cells. It can be combined intravenously with imipenem in order to protect it from dehydropeptidase. It suppresses both host and target metabolism of the broad-spectrum antibiotic imipenem, improving its efficacy. It usually confers antibiotic resistance to certain bacteria because itself does not have antibiotic activity. It has nephroprotective effects. Synonyms: (2Z)-7-[[(2R)-2-amino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-2-heptenoic Acid Ammonium Salt; MK-791 Ammonium Salt. Grades: > 95%. CAS No. 877674-82-3. Molecular formula: C16H29N3O5S. Mole weight: 375.48. | |
Cilastatin sodium Quick inquiry Where to buy Suppliers range | Cilastatin sodium. Group: Main Products. Alternative Names: 2-heptenoicacid, 7-((2-amino-2-carboxyethyl)thio)-2-(((2, 2-dimethylcyclopropyl; l642957; monosodiumsalt, (r-(r*, s*(z)))-)carbonyl)amino); sodium hydrogen [R-[R*, S*- (Z) ]]-7-[ (2-amino-2-carboxylatoethyl) thio]-2-[[ (2, 2-dimethylcyclopropyl) carbonyl]amino]hept-2-enoate; Cilastatine; Cilastatin sodium;Sodium 7-(2-amino-2-carboxy-ethyl)sulfanyl-2-(2,2-dimethylcyclopropyl)carbonylamino-hept-2-enoate;Sodium hydrogen 7-[ (2-amino-2-carboxylatoethyl) thio]-2-[[ (2, 2-dimethylcyclopropyl) carbonyl]amino]hept-2-enoate. Grades: 95%+. CAS No. 81129-83-1. Product ID: ACM81129831. Molecular formula: C16H25N2O5S.Na. Mole weight: 380.44. IUPAC Name: sodium; (Z) -7- [ (2R) -2-amino-2-carboxyethyl] sulfanyl-2- [ [ (1S) -2, 2-dimethylcyclopropanecarbonyl] amino] hept-2-enoate. Appearance: A white colour powder. EC Number: 279-694-4. Boiling Point: 655.5ºC at 760 mmHg. Flash Point: 350.2ºC. | |
Cilastatin sodium Quick inquiry Where to buy Suppliers range | Cilastatin sodium. Group: Biochemicals. Grades: Highly Purified. CAS No. 81129-83-1. Pack Sizes: 100mg, 250mg, 500mg, 1g, 2g. Molecular Formula: C16H25N2NaO5S. US Biological Life Sciences. | Worldwide |
Cilastatin sodium Quick inquiry Where to buy Suppliers range | Cilastatin sodium is the sodium salt of cilastatin, which is a dipeptidase inhibitor of renal enzyme dehydropeptidase-I and leukotriene D4 peptidase. It inhibits metabolism of LTD4 to LTE4 and the hydrolysis of β-lactam antibiotics. It reduces toxic accumulation of cyclosporin A in kidney proximal tubule epithelial cells. It can be combined intravenously with imipenem in order to protect it from dehydropeptidase. It suppresses both host and target metabolism of the broad-spectrum antibiotic imipenem, improving its efficacy. It usually confers antibiotic resistance to certain bacteria because itself does not have antibiotic activity. It has nephroprotective effects. Synonyms: L 642957; MK 791; L642957; MK791; L-642957; MK-791; [R-[R*,S*-(Z)]]-7-[(2-Amino-2-carboxyethyl)thio]-2-[[(2,2-dimethylcyclopropyl)carbonyl]amino]-2-heptenoic Acid Monosodium Salt; (2Z) ?-7- [ [ (2R) ?-2-Amino-2-carboxyethyl] ?thio] ?-2- [ [ [ (1S) ?-2, ?2-dimethylcyclopropyl] ?carbonyl] ?amino] ?-2-heptenoic Acid Sodium Salt; sodium S-((Z)-6-carboxy-6-((S)-2,2-dimethylcyclopropane-1-carboxamido)hex-5-en-1-yl)-L-cysteinate. Grades: ≥99% by HPLC. CAS No. 81129-83-1. Molecular formula: C16H25N2NaO5S. Mole weight: 380.43. | |
1S,2S-Cilastatin Hydrochloride Quick inquiry Where to buy Suppliers range | 1S,2S-Cilastatin Hydrochloride is a diastereoisomer of Cilastatin (C441100), which prevents renal metabolism of penem and carbapenem antibiotics by specific and reversible dehydropeptidase I inhibition. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg, 25mg. Molecular Formula: C16H26N2O5S; (HCl), Molecular Weight: 358.453645999999. US Biological Life Sciences. | Worldwide |
(2Z) ?-7-?Chloro-?2-? [ [ [ (1S) ?-?2, ?2-?dimethylcyclopropyl] ?carbonyl] ?amino] ?-?2-?heptenoic Acid Quick inquiry Where to buy Suppliers range | (2Z) ?-7-?Chloro-?2-? [ [ [ (1S) ?-?2, ?2-?dimethylcyclopropyl] ?carbonyl] ?amino] ?-?2-?heptenoic Acid is a reagent used in the preparation of Cilastatin (C441105), prevents renal metabolism of penem and carbapenem antibiotics by specific and reversible dehydropeptidase I inhibition. Antibacterial adjunct. Group: Biochemicals. Grades: Highly Purified. CAS No. 877674-77-6. Pack Sizes: 1g, 5g. Molecular Formula: C13H20ClNO3. US Biological Life Sciences. | Worldwide |
(4S,6S)-6-(Cyanomethyl)-2,2-dimethyl-1,3-dioxane-4-acetic Acid tert-Butyl Ester Quick inquiry Where to buy Suppliers range | (4S,6S)-6-(Cyanomethyl)-2,2-dimethyl-1,3-dioxane-4-acetic Acid tert-Butyl Ester, a predominant intermediary in the production of cilastatin in the pharmaceutical industry, boasts versatile applications. Its superior antibacterial properties make it a promising combatant in the treatment of bacterial infections. It further plays a critical role in the production of antibiotics and other biologically active compounds, justifying its pivotal place in scientific research. Synonyms: (4S,6S)-6-(Cyanomethyl)-2,2-dimethyl-1,3-dioxane-4-acetic Acid 1,1-Dimethylethyl Ester; (4S-cis)-6-(Cyanomethyl)-2,2-dimethyl-1,3-dioxane-4-acetic Acid 1,1-Dimethylethyl Ester. Grades: ≥95% by HPLC. CAS No. 196085-85-5. Molecular formula: C14H23NO4. Mole weight: 269.34. |