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| Product | Description | |
|---|---|---|
| Cilengitide | Cilengitide (EMD 121974) is a potent integrins antagonist with IC50s of 0.61 nM (???3), 8.4 nM (???5) and 14.9 nM (?5?1), respectively. Cilengitide inhibits the binding of ???3 and ???5 to Vitronectin with IC50s of 4 nM and 79 nM, respectively. Cilengitide inhibits TGF-?/Smad signaling, mediates PD-L1 expression. Cilengitide also induces apoptosis, shows antiangiogenic effect in the research against glioblastoma and other cancers[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: EMD 121974. CAS No. 188968-51-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16141. |  |
| Cilengitide | Cilengitide is a cyclic Arg-Gly-Asp peptide with potential antineoplastic activity. Cilengitide binds to and inhibits the activities of the alpha(V)beta(3) and alpha(V)beta(5) integrins, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis. It is being studied for the treatment of glioblastoma. Synonyms: 2-[(2S,5R,8S,11S)-5-benzyl-11-[3-(diaminomethylideneamino)propyl]-7-methyl-3,6,9,12,15-pentaoxo-8-propan-2-yl-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid. Grade: ≥98%. CAS No. 188968-51-6. Molecular formula: C27H40N8O7. Mole weight: 588.65. |  |
| Cilengitide TFA | Cilengitide is a potent and selective integrin inhibitor for ?v?3 and ?v?5 receptor, with IC50 values of 4 nM and 79 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: EMD 121974 TFA. CAS No. 199807-35-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16143. | |
| Cilengitide TFA salt | Cilengitide TFA salt, is a cyclic Arg-Gly-Asp acid pentapeptide that induces anoikis in angiogenic blood vessels and brain tumor, selectively and potently blocks the ligation of theαvβ3 andαvβ5 integrins to provisional matrix proteins such as vitronectin, fibronectin, fibrinogen, von Willebrand factor, osteopontin, and others. Synonyms: Cilengitide trifluoroacetate. Grade: >98%. CAS No. 199807-35-7. Molecular formula: C29H41F3N8O9. Mole weight: 702.68. | |
| Cilengitide trifluoroacetic acid salt | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
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