Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
| Product | Description | |
|---|---|---|
| Ciliobrevin A | Ciliobrevin A (HPI-4) is a hedgehog (Hh) signaling pathway inhibitor with median inhibitory concentration (IC50) less than 10 ?M[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: HPI-4. CAS No. 302803-72-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100790. |  |
| Ciliobrevin A | Ciliobrevin A is a Hedgehog (Hh) pathway inhibitor that blocks Hh pathway activation and decreases Smo ciliary accumulation in a constitutively active Hh cell line. It perturbs primary cilia formation, leads to disruption of Gli1/Gli2 activity, and suppresses primary cilia-related protein intraflagellar transport protein IFT88 expression. It inhibits cell proliferation, invasion and migration ability in human chondrosarcoma. Synonyms: HPI-4; Hedgehog Pathway Inhibitor 4; (E)-3-(2,4-dichlorophenyl)-3-oxo-2-(4-oxo-3,4-dihydroquinazolin-2(1H)-ylidene)propanenitrile. Grade: >98%. CAS No. 302803-72-1. Molecular formula: C17H9Cl2N3O2. Mole weight: 358.18. |  |
| Ciliobrevin A | Ciliobrevin A is a Hedgehog pathway inhibitor; ciliogenesis inhibitor. The Hedgehog (HH) signaling pathway is targeted for anti-cancer therapeutics. Ciliobrevin A inhibited proliferation of cerebellar granula neuron precursor cells, an important model of HH signaling. Group: Biochemicals. Alternative Names: 2,4-Dichloro-α-(3,4-dihydro-4-oxo-2(1H)-quinazolinylidene)- β -oxo Benzene propanenitrile; HPI-4. Grades: Highly Purified. CAS No. 302803-72-1. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| Cytoplasmic Dynein Inhibitor, Ciliobrevin D (2- (7-chloro-4-oxo-3, 4-dihydroquinazolin-2 (1H)-ylidene)-3- (2, 4-dichlorophenyl)-3-oxopropanenitrile) (AAA+ ATPase Motor Cytoplasmic Dynein Inhibitor) | A cell-permeable benzoyl dihydroquinazolinone derivative that acts as a reversible and specific blocker of AAA+ ATPase motor cytoplasmic dynein and disrupts spindle pole focusing, cold-stable microtubule formation, kinetochore-microtubule attachment, and melanosome aggregation in a dose-dependent manner (~10-40uM). Shown to perturb protein trafficking within the primary cilia and cause a significant increase in intraflagellar transport protein 88 (IFT88) levels at the distal tip of primary cilia. Reported to disrupt primary cilium-dependent Gli regulation and block Hedgehog signaling. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Ciliobrevin D | Ciliobrevin D is a cell-permeable, reversible and specific inhibitor of AAA+ ATPase motor cytoplasmic dynein. Ciliobrevin D inhibits Hedgehog (Hh) signaling and primary cilia formation. Ciliobrevin D inhibits dynein-dependent microtubule gliding and ATPase activity in vitro[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1370554-01-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-122632. | |
| Ciliobrevin D | Ciliobrevin D is an inhibitor of dynein ATPase activity that prevents the cycling activity of the motor protein. It inhibits the bi-directional transport of organelles along sensory axons and impairs NGF-mediated regulation of growth cones and axon branches. CAS No. 1370554-01-0. Molecular formula: C17H8Cl3N3O2. Mole weight: 392.62. | |
Our database is helping our users find suppliers everyday.
